How to stent the ureter after kidney transplantation in children?—A comparison of two methods of urinary drainage
Anuradha S. ter Haar
Department of Pediatric Nephrology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands
Search for more papers by this authorRulan S. Parekh
Department of Pediatric Nephrology, The Hospital for Sick Children, University of Toronto, Toronto, Canada
Search for more papers by this authorRalph W. J. Leunissen
Department of Pediatric Nephrology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands
Search for more papers by this authorJoop van den
Department of Pediatric Urology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands
Search for more papers by this authorArmando J. Lorenzo
Division of Urology, The Hospital for Sick Children, University of Toronto, Toronto, Canada
Search for more papers by this authorDiane Hebert
Department of Pediatric Nephrology, The Hospital for Sick Children, University of Toronto, Toronto, Canada
Search for more papers by this authorMandy G. Keijzer-Veen
Department of Pediatric Nephrology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
Search for more papers by this authorCorresponding Author
Karlien Cransberg
Department of Pediatric Nephrology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands
Correspondence
Karlien Cransberg, Department of Pediatric Nephrology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.
Email: [email protected]
Search for more papers by this authorAnuradha S. ter Haar
Department of Pediatric Nephrology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands
Search for more papers by this authorRulan S. Parekh
Department of Pediatric Nephrology, The Hospital for Sick Children, University of Toronto, Toronto, Canada
Search for more papers by this authorRalph W. J. Leunissen
Department of Pediatric Nephrology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands
Search for more papers by this authorJoop van den
Department of Pediatric Urology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands
Search for more papers by this authorArmando J. Lorenzo
Division of Urology, The Hospital for Sick Children, University of Toronto, Toronto, Canada
Search for more papers by this authorDiane Hebert
Department of Pediatric Nephrology, The Hospital for Sick Children, University of Toronto, Toronto, Canada
Search for more papers by this authorMandy G. Keijzer-Veen
Department of Pediatric Nephrology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
Search for more papers by this authorCorresponding Author
Karlien Cransberg
Department of Pediatric Nephrology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands
Correspondence
Karlien Cransberg, Department of Pediatric Nephrology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.
Email: [email protected]
Search for more papers by this authorAbstract
Ureteral stenting after pediatric renal transplantation serves to prevent obstruction and urinary leakage, but can also cause complications. This study compares the complication rates of both methods. Data were retrospectively collected at Erasmus MC, Rotterdam, the Netherlands (splint group, n = 61) and Hospital for Sick Children, Toronto, Canada (JJ catheter group, n = 50). Outcome measures included urological interventions and incidence of UTIs during the first 3 months post-transplantation. The splint was removed after a median of 9 (IQR 8-12), the JJ catheter after 42 (IQR 36-50) days. Seven (11.5%) children in the splint group needed at least one urological re-intervention versus two in the JJ catheter group (P-value .20). UTIs developed in 19 children (31.1%) in the splint group and in twenty-five (50.0%) children in the JJ catheter group (P-value .04), with a total number of 27 vs. 57 UTIs (P-value .02). Nine (33.3%) vs. 35 (61.4%) of these, respectively, occurred during the presence of the splint (P-value <.001). Children with a JJ catheter developed more UTIs than children with a splint; the latter, however, tended to require more re-interventions. Modification of either method is needed to find the best way to stent the ureter.
REFERENCES
- 1Cecka M. Clinical outcome of renal transplantation. Factors influencing patient and graft survival. Surg Clin North Am. 1998; 78: 133-148.
- 2Kari JA, Romagnoli J, Duffy P, Fernando ON, Rees L, Trompeter RS. Renal transplantation in children under 5 years of age. Pediatr Nephrol. 1999; 13: 730-736.
- 3Alberts VP, Minnee RC, Bemelman FJ, van Donselaar-van der Pant KA, Laguna Pes P, Idu MM. Ureteral reconstruction after renal transplantation: clinical outcome and risk factors. Urol Int. 2012; 88: 333-337.
- 4Irtan S, Maisin A, Baudouin V, et al. Renal transplantation in children: critical analysis of age related surgical complications. Pediatr Transplant. 2010; 14: 512-519.
- 5Martino P, Impedovo SV, Palazzo S, et al. Ureteral strictures after kidney transplantation: risk factors. Arch Ital Urol Androl. 2012; 84: 287-290.
- 6Almeida F, Branco F, Cavadas V, et al. Urological complications after 134 pediatric kidney transplants: a single-center study. Transplant Proc. 2013; 45: 1096-1098.
- 7Simpson CM, Sterne JA, Walker RG, Francis DM, Robertson AJ, Jones CL. Stent-related ureteric obstruction in paediatric renal transplantation. Pediatr Nephrol. 2006; 21: 79-85.
- 8Tavakoli A, Surange RS, Pearson RC, Parrott NR, Augustine T, Riad HN. Impact of stents on urological complications and health care expenditure in renal transplant recipients: results of a prospective, randomized clinical trial. J Urol. 2007; 177: 2260-2264; discussion 4.
- 9Harza M, Baston C, Preda A, et al. Impact of ureteral stenting on urological complications after kidney transplantation surgery: a single-center experience. Transplant Proc. 2014; 46: 3459-3462.
- 10Akoh JA, Rana T. Effect of ureteric stents on urological infection and graft function following renal transplantation. World J Transplant. 2013; 3: 1-6.
- 11Dharnidharka VR, Araya CE, Wadsworth CS, McKinney MC, Howard RJ. Assessing the value of ureteral stent placement in pediatric kidney transplant recipients. Transplantation. 2008; 85: 986-991.
- 12Randhawa P, Brennan DC. BK virus infection in transplant recipients: an overview and update. Am J Transplant. 2006; 6: 2000-2005.
- 13Mangus RS, Haag BW. Stented versus nonstented extravesical ureteroneocystostomy in renal transplantation: a metaanalysis. Am J Transplant. 2004; 4: 1889-1896.
- 14Wilson CH, Rix DA, Manas DM. Routine intraoperative ureteric stenting for kidney transplant recipients. Cochrane Database Syst Rev. 2013; 17: CD004925.
- 15Sansalone CV, Maione G, Aseni P, et al. Advantages of short-time ureteric stenting for prevention of urological complications in kidney transplantation: an 18-year experience. Transplant Proc. 2005; 37: 2511-2515.
- 16Georgiev P, Boni C, Dahm F, et al. Routine stenting reduces urologic complications as compared with stenting “on demand” in adult kidney transplantation. Urology. 2007; 70: 893-897.
- 17Ordon M, Ghiculete D, Stewart R, Pace KT, Honey RJ. The role of prophylactic versus selective ureteric stenting in kidney transplant patients: a retrospective review. Prog Transplant. 2014; 24: 322-327.
10.7182/pit2014422 Google Scholar
- 18Minnee RC, Bemelman FJ, Laguna Pes PP, ten Berge IJ, Legemate DA, Idu MM. Effectiveness of a 5-day external stenting protocol on urological complications after renal transplantation. World J Surg. 2009; 33: 2722-2726.
10.1007/s00268-009-0224-y Google Scholar
- 19Gedroyc WM, Koffman G, Saunders AJ. Ureteric obstruction in stented renal transplants. Br J Urol. 1988; 62: 123-126.
- 20Bergmeijer JH, Nijman R, Kalkman E, Nauta J, Wolff ED, Molenaar JC. Stenting of the ureterovesical anastomosis in pediatric renal transplantation. Transpl Int. 1990; 3: 146-148.
- 21French CG, Acott PD, Crocker JF, Bitter-Suermann H, Lawen JG. Extravesical ureteroneocystostomy with and without internalized ureteric stents in pediatric renal transplantation. Pediatr Transplant. 2001; 5: 21-26.
- 22Indu KN, Lakshminarayana G, Anil M, et al. Is early removal of prophylactic ureteric stents beneficial in live donor renal transplantation? Indian J Nephrol. 2012; 22: 275-279.
- 23Parapiboon W, Ingsathit A, Disthabanchong S, et al. Impact of early ureteric stent removal and cost-benefit analysis in kidney transplant recipients: results of a randomized controlled study. Transplant Proc. 2012; 44: 737-739.
- 24Fockens MM, Alberts VP, Bemelman FJ, Laguna Pes MP, Idu MM. Internal or external stenting of the ureterovesical anastomosis in renal transplantation. Urol Int. 2016; 96: 152-156.
- 25Silva A, Rodig N, Passerotti CP, et al. Risk factors for urinary tract infection after renal transplantation and its impact on graft function in children and young adults. J Urol. 2010; 184: 1462-1467.
- 26Mathe Z, Treckmann JW, Heuer M, et al. Stented ureterovesical anastomosis in renal transplantation: does it influence the rate of urinary tract infections? Eur J Med Res. 2010; 15: 297-302.
- 27Patel P, Rebollo-Mesa I, Ryan E, et al. Prophylactic ureteric stents in renal transplant recipients: a multicenter randomized controlled trial of early versus late removal. Am J Transplant. 2017; 17: 2129-2138.
- 28Maliakkal JG, Brennan DC, Goss C, et al. Ureteral stent placement and immediate graft function are associated with increased risk of BK viremia in the first year after kidney transplantation. Transpl Int. 2017; 30: 153-161.
- 29Hashim F, Rehman S, Gregg JA, Dharnidharka VR. Ureteral stent placement increases the risk for developing BK Viremia after kidney transplantation. J Transplant. 2014; 2014: 459747.
- 30Bardapure M, Sharma A, Hammad A. Forgotten ureteric stents in renal transplant recipients: three case reports. Saudi J Kidney Dis Transpl. 2014; 25: 109-112.