Review Article
The evolving potential for pediatric ex vivo lung perfusion
Jessica G.Y. Luc,
Jayan Nagendran,
Jessica G.Y. Luc
Division of Cardiac Surgery, Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada
Mazankowski Alberta Heart Institute, Edmonton, AB, Canada
Search for more papers by this authorCorresponding Author
Jayan Nagendran
Division of Cardiac Surgery, Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada
Mazankowski Alberta Heart Institute, Edmonton, AB, Canada
Alberta Transplant Institute, Edmonton, AB, Canada
Canadian National Transplant Research Program, Edmonton, AB, Canada
Jayan Nagendran, MD, PhD, FRCSC, Surgeon and Director of Research, Division of Cardiac Surgery, Department of Surgery, University of Alberta and Mazankowski Alberta Heart Institute, 2D2.18 WMC, 8440-112 Street, Edmonton, AB T6G-2B7, Canada
Tel.: 780 407 6327
Fax: 780 407 6752
E-mail: [email protected]
Search for more papers by this authorJessica G.Y. Luc,
Jayan Nagendran,
Jessica G.Y. Luc
Division of Cardiac Surgery, Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada
Mazankowski Alberta Heart Institute, Edmonton, AB, Canada
Search for more papers by this authorCorresponding Author
Jayan Nagendran
Division of Cardiac Surgery, Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada
Mazankowski Alberta Heart Institute, Edmonton, AB, Canada
Alberta Transplant Institute, Edmonton, AB, Canada
Canadian National Transplant Research Program, Edmonton, AB, Canada
Jayan Nagendran, MD, PhD, FRCSC, Surgeon and Director of Research, Division of Cardiac Surgery, Department of Surgery, University of Alberta and Mazankowski Alberta Heart Institute, 2D2.18 WMC, 8440-112 Street, Edmonton, AB T6G-2B7, Canada
Tel.: 780 407 6327
Fax: 780 407 6752
E-mail: [email protected]
Search for more papers by this authorAbstract
Despite the rise in the number of adult lung transplantations performed, rates of pediatric lung transplantation remain low. Lung transplantation is an accepted therapy for pediatric end-stage lung disease; however, it is limited by a shortage of donor organs. EVLP has emerged as a platform for assessment and preservation of donor lung function. EVLP has been adopted in adult lung transplantation and has successfully led to increased adult lung transplantations and donor lung utilization. We discuss the future implications of EVLP utilization, specifically, its potential evolving role in overcoming donor shortages in smaller children and adolescents to improve the quality and outcomes of lung transplantation in pediatric patients.
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