Optimizing the utilization of kidneys from small pediatric deceased donors under 15 kg by choosing pediatric recipients
Mingxing Sui
Organ Transplantation Center, Changhai Hospital, Second Military Medical University, Shanghai, China
These authors contributed equally to this work.Search for more papers by this authorWenyu Zhao
Organ Transplantation Center, Changhai Hospital, Second Military Medical University, Shanghai, China
These authors contributed equally to this work.Search for more papers by this authorYu Chen
Organ Transplantation Institute of PLA, Changzheng Hospital, Second Military Medical University, Shanghai, China
Search for more papers by this authorFanyuan Zhu
Organ Transplantation Institute of PLA, Changzheng Hospital, Second Military Medical University, Shanghai, China
Search for more papers by this authorYouhua Zhu
Organ Transplantation Center, Changhai Hospital, Second Military Medical University, Shanghai, China
Search for more papers by this authorCorresponding Author
Li Zeng
Organ Transplantation Center, Changhai Hospital, Second Military Medical University, Shanghai, China
Li Zeng, Organ Transplantation Center, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
Tel.: 86 13601618099
Fax: 8621 81886600
E-mail: [email protected]
Or
Lei Zhang, Organ Transplantation Institute of PLA, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
Tel.: 86 18017284099
Fax: 8621 63524488
E-mail: [email protected]
Search for more papers by this authorCorresponding Author
Lei Zhang
Organ Transplantation Institute of PLA, Changzheng Hospital, Second Military Medical University, Shanghai, China
Li Zeng, Organ Transplantation Center, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
Tel.: 86 13601618099
Fax: 8621 81886600
E-mail: [email protected]
Or
Lei Zhang, Organ Transplantation Institute of PLA, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
Tel.: 86 18017284099
Fax: 8621 63524488
E-mail: [email protected]
Search for more papers by this authorMingxing Sui
Organ Transplantation Center, Changhai Hospital, Second Military Medical University, Shanghai, China
These authors contributed equally to this work.Search for more papers by this authorWenyu Zhao
Organ Transplantation Center, Changhai Hospital, Second Military Medical University, Shanghai, China
These authors contributed equally to this work.Search for more papers by this authorYu Chen
Organ Transplantation Institute of PLA, Changzheng Hospital, Second Military Medical University, Shanghai, China
Search for more papers by this authorFanyuan Zhu
Organ Transplantation Institute of PLA, Changzheng Hospital, Second Military Medical University, Shanghai, China
Search for more papers by this authorYouhua Zhu
Organ Transplantation Center, Changhai Hospital, Second Military Medical University, Shanghai, China
Search for more papers by this authorCorresponding Author
Li Zeng
Organ Transplantation Center, Changhai Hospital, Second Military Medical University, Shanghai, China
Li Zeng, Organ Transplantation Center, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
Tel.: 86 13601618099
Fax: 8621 81886600
E-mail: [email protected]
Or
Lei Zhang, Organ Transplantation Institute of PLA, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
Tel.: 86 18017284099
Fax: 8621 63524488
E-mail: [email protected]
Search for more papers by this authorCorresponding Author
Lei Zhang
Organ Transplantation Institute of PLA, Changzheng Hospital, Second Military Medical University, Shanghai, China
Li Zeng, Organ Transplantation Center, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
Tel.: 86 13601618099
Fax: 8621 81886600
E-mail: [email protected]
Or
Lei Zhang, Organ Transplantation Institute of PLA, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
Tel.: 86 18017284099
Fax: 8621 63524488
E-mail: [email protected]
Search for more papers by this authorAbstract
Currently, most kidneys from small pediatric deceased donors are transplanted into adult recipients (i.e., PTA). However, due to the weight mismatch, there is a high discard rate and a high ratio of EBKTs if adopting PTA. Here, we sought both to optimize utilization of these challenging but scarce donor grafts by selecting pediatric recipients and to characterize the feasibility and efficacy of this PTP allocation strategy. From February 2012 to October 2014, kidneys from 27 infant donors ≤15 kg were procured and distributed to 38 pediatric candidates in our center. The grafts were utilized for EBKT if the donor weighed 2.5–5 kg and for SKT if the donor weighed 5–15 kg, leading to 10 EBKTs and 28 SKTs. The overall utilization rate from small pediatric deceased donors was 94.12%. After a follow-up of 3–26 months, the graft survival rate was 89.47%, with four graft losses due to vascular thrombosis. Kidneys from low-body-weight donors should be applied to pediatric recipients, and the kidneys from infant donors ≥5 kg can be used in single-kidney-transplant procedures at experienced centers to optimize utilization.
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