Male assignment in 5α-reductase type 2 deficiency with female external genitalia
Ayako Konishi
Department of Gastroenterology, Nutrition and Endocrinology, Osaka Women's and Children's Hospital, Izumi, Osaka, Japan
Department of Pediatrics, Kashibaseiki Hospital, Kashiba, Japan
Search for more papers by this authorShinobu Ida
Department of Gastroenterology, Nutrition and Endocrinology, Osaka Women's and Children's Hospital, Izumi, Osaka, Japan
Department of Clinical Laboratory, Osaka Women's and Children's Hospital, Izumi, Osaka, Japan
Search for more papers by this authorFutoshi Matsui
Department of Urology, Osaka Women's and Children's Hospital, Izumi, Osaka, Japan
Search for more papers by this authorYuri Etani
Department of Gastroenterology, Nutrition and Endocrinology, Osaka Women's and Children's Hospital, Izumi, Osaka, Japan
Search for more papers by this authorCorresponding Author
Masanobu Kawai
Department of Gastroenterology, Nutrition and Endocrinology, Osaka Women's and Children's Hospital, Izumi, Osaka, Japan
Department of Bone and Mineral Research, Research Institute, Osaka Women's and Children's Hospital, Izumi, Osaka, Japan
Correspondence: Masanobu Kawai, MD PhD, Department of Gastroenterology, Nutrition, and Endocrinology, Osaka Women's and Children's Hospital, 840 Murodo-cho, Izumi, Osaka 594-1101, Japan. Email: [email protected]
Search for more papers by this authorAyako Konishi
Department of Gastroenterology, Nutrition and Endocrinology, Osaka Women's and Children's Hospital, Izumi, Osaka, Japan
Department of Pediatrics, Kashibaseiki Hospital, Kashiba, Japan
Search for more papers by this authorShinobu Ida
Department of Gastroenterology, Nutrition and Endocrinology, Osaka Women's and Children's Hospital, Izumi, Osaka, Japan
Department of Clinical Laboratory, Osaka Women's and Children's Hospital, Izumi, Osaka, Japan
Search for more papers by this authorFutoshi Matsui
Department of Urology, Osaka Women's and Children's Hospital, Izumi, Osaka, Japan
Search for more papers by this authorYuri Etani
Department of Gastroenterology, Nutrition and Endocrinology, Osaka Women's and Children's Hospital, Izumi, Osaka, Japan
Search for more papers by this authorCorresponding Author
Masanobu Kawai
Department of Gastroenterology, Nutrition and Endocrinology, Osaka Women's and Children's Hospital, Izumi, Osaka, Japan
Department of Bone and Mineral Research, Research Institute, Osaka Women's and Children's Hospital, Izumi, Osaka, Japan
Correspondence: Masanobu Kawai, MD PhD, Department of Gastroenterology, Nutrition, and Endocrinology, Osaka Women's and Children's Hospital, 840 Murodo-cho, Izumi, Osaka 594-1101, Japan. Email: [email protected]
Search for more papers by this authorDisclosure
The authors declare no conflict of interest.
References
- 1Andersson S, Berman DM, Jenkins EP, Russell DW. Deletion of steroid 5 alpha-reductase 2 gene in male pseudohermaphroditism. Nature 1991; 354: 159–61.
- 2Hughes IA, Houk C, Ahmed SF, Lee PA, Group LC, Group EC. Consensus statement on management of intersex disorders. Arch. Dis. Child. 2006; 91: 554–63.
- 3Byers HM, Mohnach LH, Fechner PY et al. Unexpected ethical dilemmas in sex assignment in 46,XY DSD due to 5-alpha reductase type 2 deficiency. Am. J. Med. Genet. C Semin. Med. Genet. 2017; 175: 260–7.
- 4Kang HJ, Imperato-McGinley J, Zhu YS, Rosenwaks Z. The effect of 5alpha-reductase-2 deficiency on human fertility. Fertil. Steril. 2014; 101: 310–6.
- 5Walter KN, Kienzle FB, Frankenschmidt A et al. Difficulties in diagnosis and treatment of 5alpha-reductase type 2 deficiency in a newborn with 46 XY DSD. Horm. Res. Paediatr. 2010; 74: 67–71.
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