Safety of the breast-feeding infant after maternal anesthesia
Corresponding Author
Priti G. Dalal
Department of Anesthesiology, Penn State University College of Medicine, Milton S Hershey Medical Center, Hershey, PA, USA
Correspondence
Priti G. Dalal, Department of Anesthesiology, Penn State Hershey Medical Center, 500 University Drive, H187, Hershey, PA 17033, USA
Email: [email protected]
Search for more papers by this authorJodi Bosak
Anesthesiologists of Greater Orlando, Winter Park, FL, USA
Search for more papers by this authorCheston Berlin
Department of Pediatrics, Penn State University College of Medicine, Milton S Hershey Medical Center, Hershey, PA, USA
Search for more papers by this authorCorresponding Author
Priti G. Dalal
Department of Anesthesiology, Penn State University College of Medicine, Milton S Hershey Medical Center, Hershey, PA, USA
Correspondence
Priti G. Dalal, Department of Anesthesiology, Penn State Hershey Medical Center, 500 University Drive, H187, Hershey, PA 17033, USA
Email: [email protected]
Search for more papers by this authorJodi Bosak
Anesthesiologists of Greater Orlando, Winter Park, FL, USA
Search for more papers by this authorCheston Berlin
Department of Pediatrics, Penn State University College of Medicine, Milton S Hershey Medical Center, Hershey, PA, USA
Search for more papers by this authorSummary
There has been an increase in breast-feeding supported by the recommendations of the American Academy of Pediatrics and the World Health Organization. An anesthesiologist may be presented with a well-motivated breast-feeding mother who wishes to breast-feed her infant in the perioperative period. Administration of anesthesia entails acute administration of drugs with potential for sedation and respiratory effects on the nursing infant. The short-term use of these drugs minimizes the possibility of these effects. The aim should be to minimize the use of narcotics and benzodiazepines, use shorter acting agents, use regional anesthesia where possible and avoid agents with active metabolites. Frequent clinical assessments of the nursing infant are important. Available literature does suggest that although the currently available anesthetic and analgesic drugs are transferred in the breast milk, the amounts transferred are almost always clinically insignificant and pose little or no risk to the nursing infant.
References
- 1Rautava S, Walker WA. Academy of Breastfeeding Medicine founder's lecture 2008: breastfeeding–an extrauterine link between mother and child. Breastfeed Med 2009; 4: 3–10.
- 2Lawrence PB. Breast milk. Best source of nutrition for term and preterm infants. Pediatr Clin North Am 1994; 41: 925–941.
- 3Eidelman AI, Schanler RJ. American Academy of Pediatric section on breast feeding: breastfeeding and the Use of Human Milk. Pediatrics 2012; 129: e827–e841.
- 4Gartner LM, Morton J, Lawrence RA et al. Breastfeeding and the use of human milk. Pediatrics 2005; 115: 496–506.
- 5Heird WC. Progress in promoting breast-feeding, combating malnutrition, and composition and use of infant formula, 1981–2006. J Nutr 2007; 137: 499S–502S.
- 6Labbok MH, Clark D, Goldman AS. Breastfeeding: maintaining an irreplaceable immunological resource. Nat Rev Immunol 2004; 4: 565–572.
- 7Ruiz-Palacios GM, Calva JJ, Pickering LK et al. Protection of breast-fed infants against Campylobacter diarrhea by antibodies in human milk. J Pediatr 1990; 116: 707–713.
- 8Xanthou M, Bines J, Walker WA. Human milk and intestinal host defense in newborns: an update. Adv Pediatr 1995; 42: 171–208.
- 9Gillman MW, Rifas-Shiman SL, Camargo CA Jr et al. Risk of overweight among adolescents who were breastfed as infants. JAMA 2001; 285: 2461–2467.
- 10Labbok MH, Hight-Laukaran V, Peterson AE et al. Multicenter study of the Lactational Amenorrhea Method (LAM): I. Efficacy, duration, and implications for clinical application. Contraception 1997; 55: 327–336.
- 11Clavano NR. Mode of feeding and its effect on infant mortality and morbidity. J Trop Pediatr 1982; 28: 287–293.
- 12Lee JJ, Rubin AP. Breast feeding and anaesthesia. Anaesthesia 1993; 48: 616–625.
- 13Lang C, Geldner G, Wulf H. Anesthesia in the breast feeding period. Excretion of anesthetic agents and adjuvants into breast milk and potential pharmacological side-effects on the suckling infant. Anaesthesist 2003; 52: 934–946.
- 14Bond GM, Holloway AM. Anaesthesia and breast-feeding–the effect on mother and infant. Anaesth Intensive Care 1992; 20: 426–430.
- 15Hale TW. Anesthetic medications in breastfeeding mothers. J Hum Lact 1999; 15: 185–194.
- 16Lawrence RA, Lawrence RM. Physiology of Lactation. 7th edn, Chapter 3. Maryland Heights, MO: Elsevier Mosby, Inc, 2011: 62–97.
- 17Anderson PO, Valdes V. A critical review of pharmaceutical galactagogues. Breastfeed Med 2007; 2: 229–242.
- 18Sachs HC. The transfer of drugs and therapeutics into human breast milk: an update on selected topics. Pediatrics 2013; 132: e796–e809.
- 19Wilson JT, Brown RD, Cherek DR et al. Drug excretion in human breast milk: principles, pharmacokinetics and projected consequences. Clin Pharmacokinet 1980; 5: 1–66.
- 20Hale TW. Maternal medications during breastfeeding. Clin Obstet Gynecol 2004; 47: 696–711.
- 21Ito S, Lee A. Drug excretion into breast milk – overview. Adv Drug Deliv Rev 2003; 55: 617–627.
- 22Bowes WA Jr. The effect of medications on the lactating mother and her infant. Clin Obstet Gynecol 1980; 23: 1073–1080.
- 23Lawrence RA, Lawrence RM. Medications, Herbal Preparations, and Natural Products in Breast Milk. 7th edn, Chapter 12. Maryland Heights, MO: Elsevier Mosby, Inc, 2011: 364–405.
- 24Atkinson HC, Begg EJ, Darlow BA. Drugs in human milk. Clinical pharmacokinetic considerations. Clin Pharmacokinet 1988; 14: 217–240.
- 25Anderson PO. Drug use during breast-feeding. Clin Pharm 1991; 10: 594–624.
- 26Lawrence RA, Lawrence RM. Biochemistry of Human Milk. 7th edn, Chapter 4. Maryland Heights, MO: Elsevier Mosby, Inc, 2011: 98–152.
- 27Ito S, Koren G. A novel index for expressing exposure of the infant to drugs in breast milk. Br J Clin Pharmacol 1994; 38: 99–102.
- 28Horlocker TT, Brown DR. Evidence-based medicine: haute couture or the emperor's new clothes? Anesth Analg 2005; 100: 1807–1810.
- 29Sear JW. Essential drugs in anesthetic practice: clinical pharmacology of intravenous anesthetics. In: MM Alex Evers, K Evan, eds. Anesthetic Pharmacology: Basic Principles and Clinical Practice, 2nd edn. Cambridge, UK: Cambridge University Press, 2011: 444–465.
10.1017/CBO9780511781933.029 Google Scholar
- 30Birkholz T, Eckardt G, Renner S et al. Green breast milk after propofol administration. Anesthesiology 2009; 111: 1168–1169.
- 31Nitsun M, Szokol JW, Saleh HJ et al. Pharmacokinetics of midazolam, propofol, and fentanyl transfer to human breast milk. Clin Pharmacol Ther 2006; 79: 549–557.
- 32Dailland P, Cockshott ID, Lirzin JD et al. Intravenous propofol during cesarean section: placental transfer, concentrations in breast milk, and neonatal effects. A preliminary study. Anaesthesiology 1989; 71: 827–834.
- 33Andersen LW, Qvist T, Hertz J et al. Concentrations of thiopentone in mature breast milk and colostrum following an induction dose. Acta Anaesthesiol Scand 1987; 31: 30–32.
- 34Esener Z, Sarihasan B, Guven H et al. Thiopentone and etomidate concentrations in maternal and umbilical plasma, and in colostrum. Br J Anaesth 1992; 69: 586–588.
- 35Yamamuro Y. Exposure to common anesthetic agents alters pup-retrieval response in lactating rats. Exp Anim 2005; 54: 369–372.
- 36Stuttmann R, Schafer C, Hilbert P et al. The breast feeding mother and xenon anaesthesia: four case reports. Breast feeding and xenon anaesthesia. BMC Anesthesiol 2010; 10: 1.
- 37Byhahn C, Lischke V, Westphal K. Occupational exposure in the hospital to laughing gas and the new inhalation anesthetics desflurane and sevoflurane. Dtsch Med Wochenschr 1999; 124: 137–141.
- 38Cote CJ, Kenepp NB, Reed SB et al. Trace concentrations of halothane in human breast milk. Br J Anaesth 1976; 48: 541–543.
- 39Madej TH, Strunin L. Comparison of epidural fentanyl with sufentanil. Analgesia and side effects after a single bolus dose during elective caesarean section. Anaesthesia 1987; 42: 1156–1161.
- 40Cohen RS. Fentanyl transdermal analgesia during pregnancy and lactation. J Hum Lact 2009; 25: 359–361.
- 41Chay PC, Duffy BJ, Walker JS. Pharmacokinetic-pharmacodynamic relationships of morphine in neonates. Clin Pharmacol Ther 1992; 51: 334–342.
- 42Lynn AM, Opheim KE, Tyler DC. Morphine infusion after pediatric cardiac surgery. Crit Care Med 1984; 12: 863–866.
- 43Feilberg VL, Rosenborg D, Broen Christensen C et al. Excretion of morphine in human breast milk. Acta Anaesthesiol Scand 1989; 33: 426–428.
- 44Robieux I, Koren G, Vandenbergh H et al. Morphine excretion in breast milk and resultant exposure of a nursing infant. J Toxicol Clin Toxicol 1990; 28: 365–370.
- 45Baka NE, Bayoumeu F, Boutroy MJ et al. Colostrum morphine concentrations during postcesarean intravenous patient-controlled analgesia. Anesth Analg 2002; 94: 184–187, table of contents.
- 46Oberlander TF, Robeson P, Ward V et al. Prenatal and breast milk morphine exposure following maternal intrathecal morphine treatment. J Hum Lact 2000; 16: 137–142.
- 47Edwards JE, Rudy AC, Wermeling DP et al. Hydromorphone transfer into breast milk after intranasal administration. Pharmacotherapy 2003; 23: 153–158.
- 48Sauberan JB, Anderson PO, Lane JR et al. Breast milk hydrocodone and hydromorphone levels in mothers using hydrocodone for postpartum pain. Obstet Gynecol 2011; 117: 611–617.
- 49Stoelting RK, Hillier SC. Opioid agonists and antagonists. In: RK Stoelting, SC Hillier eds. Pharmacology & Physiology in Anesthetic Practice, 4th edn. Philadelphia: Lippincott Williams & Williams, 2006: 87–126.
- 50Douma MR, Verwey RA, Kam-Endtz CE et al. Obstetric analgesia: a comparison of patient-controlled meperidine, remifentanil, and fentanyl in labour. Br J Anaesth 2010; 104: 209–215.
- 51Stambaugh JE Jr, Lane C. Analgesic efficacy and pharmacokinetic evaluation of meperidine and hydroxyzine, alone and in combination. Cancer Invest 1983; 1: 111–117.
- 52Kuhnert BR, Kuhnert PM, Philipson EH et al. Disposition of meperidine and normeperidine following multiple doses during labor. II. Fetus and neonate. Am J Obstet Gynecol 1985; 151: 410–415.
- 53Quinn PG, Kuhnert BR, Kaine CJ et al. Measurement of meperidine and normeperidine in human breast milk by selected ion monitoring. Biomed Environ Mass Spectrom 1986; 13: 133–135.
- 54Wittels B, Scott DT, Sinatra RS. Exogenous opioids in human breast milk and acute neonatal neurobehavior: a preliminary study. Anesthesiology 1990; 73: 864–869.
- 55Al-Tamimi Y, Ilett KF, Paech MJ et al. Estimation of infant dose and exposure to pethidine and norpethidine via breast milk following patient-controlled epidural pethidine for analgesia post caesarean delivery. Int J Obstet Anesth 2011; 20: 128–134.
- 56Borgatta L, Jenny RW, Gruss L et al. Clinical significance of methohexital, meperidine, and diazepam in breast milk. J Clin Pharmacol 1997; 37: 186–192.
- 57Koren G, Cairns J, Chitayat D et al. Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother. Lancet 2006; 368: 704.
- 58Madadi P, Ross CJ, Hayden MR et al. Pharmacogenetics of neonatal opioid toxicity following maternal use of codeine during breastfeeding: a case-control study. Clin Pharmacol Ther 2009; 85: 31–35.
- 59Berlin CM Jr, Paul IM, Vesell ES. Safety issues of maternal drug therapy during breastfeeding. Clin Pharmacol Ther 2009; 85: 20–22.
- 60Lam J, Kelly L, Ciszkowski C et al. Central nervous system depression of neonates breastfed by mothers receiving oxycodone for postpartum analgesia. J Pediatr 2012; 160: 33–37.
- 61van den Anker JN. Is it safe to use opioids for obstetric pain while breastfeeding? J Pediatr 2012; 160: 4–6.
- 62Ilett KF, Paech MJ, Page-Sharp M et al. Use of a sparse sampling study design to assess transfer of tramadol and its O-desmethyl metabolite into transitional breast milk. Br J Clin Pharmacol 2008; 65: 661–666.
- 63Amiel-Tison C, Barrier G, Shnider SM et al. A new neurologic and adaptive capacity scoring system for evaluating obstetric medications in full-term newborns. Anesthesiology 1982; 56: 340–350.
- 64Stoelting RK, Hillier SC. Benzodiazepines (chapter 5). In: RK Stoelting, SC Hillier, eds. Pharmacology and Physiology in Anesthetic Practice, 4th edn. Philadelphia: Lippincott Williams & Williams, 2006: 140–154.
- 65McBride RJ, Dundee JW, Moore J et al. A study of the plasma concentrations of lorazepam in mother and neonate. Br J Anaesth 1979; 51: 971–978.
- 66Patrick MJ, Tilstone WJ, Reavey P. Diazepam and breast-feeding. Lancet 1972; 1: 542–543.
- 67Erkkola R, Kanto J. Diazepam and breast-feeding. Lancet 1972; 1: 1235–1236.
- 68Cole AP, Hailey DM. Diazepam and active metabolite in breast milk and their transfer to the neonate. Arch Dis Child 1975; 50: 741–742.
- 69Dusci LJ, Good SM, Hall RW et al. Excretion of diazepam and its metabolites in human milk during withdrawal from combination high dose diazepam and oxazepam. Br J Clin Pharmacol 1990; 29: 123–126.
- 70Summerfield RJ, Nielsen MS. Excretion of lorazepam into breast milk. Br J Anaesth 1985; 57: 1042–1043.
- 71Matheson I, Lunde PK, Bredesen JE. Midazolam and nitrazepam in the maternity ward: milk concentrations and clinical effects. Br J Clin Pharmacol 1990; 30: 787–793.
- 72Wischnik A, Manth SM, Lloyd J et al. The excretion of ketorolac tromethamine into breast milk after multiple oral dosing. Eur J Clin Pharmacol 1989; 36: 521–524.
- 73Needs CJ, Brooks PM. Antirheumatic medication during lactation. Br J Rheumatol 1985; 24: 291–297.
- 74Stoelting RK, Hillier SC. Neuromuscular-blocking drugs (chapter 8). In: RK Stoelting, SC Hillier, eds. Pharmacology & Physiology in Anesthetic Practice, 4th edn. Philadelphia: Lippincott Williams & Williams, 2006: 208–250.
- 75Stoelting RK, Hillier SC. Anticholinesterase drugs and cholinergic agonists (chapter 9). In: RK Stoelting, SC Hillier, eds. Pharmacology & Physiology in Anesthetic Practice, 4th edn. Philadelphia: Lippincott Williams & Williams, 2006: 251–265.
- 76Stoelting RK, Hillier SC. Anticholinergic drugs (chapter 10). In: RK Stoelting, SC Hillier, eds. Pharmacology & Physiology in Anesthetic Practice, 4th edn. Philadelphia: Lippincott Williams & Williams, 2006: 266–275.
- 77Fraser D, Turner JW. Myasthenia gravis and pregnancy. Proc R Soc Med 1963; 56: 379–381.
- 78Hardell LI, Lindstrom B, Lonnerholm G et al. Pyridostigmine in human breast milk. Br J Clin Pharmacol 1982; 14: 565–567.
- 79Kauppila A, Arvela P, Koivisto M et al. Metoclopramide and breast feeding: transfer into milk and the newborn. Eur J Clin Pharmacol 1983; 25: 819–823.
- 80Stoelting RK, Hillier SC. Local anesthetics (chapter 7). In: RK Stoelting, SC Hillier, eds. Pharmacology & Physiology in Anesthetic Practice, 4th edn. Philadelphia: Lippincott Williams & Williams, 2006: 179–207.
- 81Baumgarder DJ, Muehl P, Fischer M et al. Effect of labor epidural anesthesia on breast-feeding of healthy full-term newborns delivered vaginally. J Am Board Fam Pract 2003; 16: 7–13.
- 82Hirose M, Hara Y, Hosokawa T et al. The effect of postoperative analgesia with continuous epidural bupivacaine after cesarean section on the amount of breast feeding and infant weight gain. Anesth Analg 1996; 82: 1166–1169.
- 83Baker PA, Schroeder D. Interpleural bupivacaine for postoperative pain during lactation. Anesth Analg 1989; 69: 400–402.
- 84Ortega D, Viviand X, Lorec AM et al. Excretion of lidocaine and bupivacaine in breast milk following epidural anesthesia for cesarean delivery. Acta Anaesthesiol Scand 1999; 43: 394–397.
- 85Giuliani M, Grossi GB, Pileri M et al. Could local anesthesia while breast-feeding be harmful to infants? J Pediatr Gastroenterol Nutr 2001; 32: 142–144.
- 86Lie B, Juul J. Effect of epidural vs. general anesthesia on breastfeeding. Acta Obstet Gynecol Scand 1988; 67: 207–209.
- 87Kiehl EM, Anderson GC, Wilson ME et al. Social status, mother-infant time together, and breastfeeding duration. J Hum Lact 1996; 12: 201–206.
- 88Halpern SH, Levine T, Wilson DB et al. Effect of labor analgesia on breastfeeding success. Birth 1999; 26: 83–88.
- 89Berlin CM Jr. Pharmacologic considerations of drug use in the lactating mother. Obstet Gynecol 1981; 58: 17S–23S.
- 90Montgomery A, Hale TW. ABM clinical protocol #15: analgesia and anesthesia for the breastfeeding mother. Breastfeed Med 2006; 1: 271–277.
- 91Anderson PO, Pochop SL, Manoguerra AS. Adverse drug reactions in breastfed infants: less than imagined. Clin Pediatr (Phila) 2003; 42: 325–340.
- 92Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol 1993; 168: 1393–1399.