Effect of Age on the Pharmacokinetics of Marbofloxacin Following Intravenous Administration in Calves
Corresponding Author
Orhan Corum
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Hatay Mustafa Kemal, Hatay, Turkiye
Correspondence:
Orhan Corum ([email protected])
Search for more papers by this authorMurat Yuksel
Department of Obstetrics and Gyneacology, Faculty of Veterinary Medicine, University of Hatay Mustafa Kemal, Hatay, Turkiye
Search for more papers by this authorDevran Coskun
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Siirt, Siirt, Turkiye
Search for more papers by this authorDuygu Durna Corum
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Hatay Mustafa Kemal, Hatay, Turkiye
Search for more papers by this authorSerafettin Kartal
Department of Veterinary Medicine, Samandag Vocational School, Hatay Mustafa Kemal University, Hatay, Turkiye
Search for more papers by this authorMustafa Cellat
Department of Physiology, Faculty of Veterinary Medicine, University of Hatay Mustafa Kemal, Hatay, Turkiye
Search for more papers by this authorKamil Uney
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Selcuk, Konya, Turkiye
Search for more papers by this authorCorresponding Author
Orhan Corum
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Hatay Mustafa Kemal, Hatay, Turkiye
Correspondence:
Orhan Corum ([email protected])
Search for more papers by this authorMurat Yuksel
Department of Obstetrics and Gyneacology, Faculty of Veterinary Medicine, University of Hatay Mustafa Kemal, Hatay, Turkiye
Search for more papers by this authorDevran Coskun
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Siirt, Siirt, Turkiye
Search for more papers by this authorDuygu Durna Corum
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Hatay Mustafa Kemal, Hatay, Turkiye
Search for more papers by this authorSerafettin Kartal
Department of Veterinary Medicine, Samandag Vocational School, Hatay Mustafa Kemal University, Hatay, Turkiye
Search for more papers by this authorMustafa Cellat
Department of Physiology, Faculty of Veterinary Medicine, University of Hatay Mustafa Kemal, Hatay, Turkiye
Search for more papers by this authorKamil Uney
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Selcuk, Konya, Turkiye
Search for more papers by this authorFunding: The authors received no specific funding for this work.
ABSTRACT
The aim of this study was to compare the pharmacokinetics of marbofloxacin after intravenous (IV) administration of a single dose of 10 mg/kg to calves of different ages. The study was carried on 1- (n = 6), 2- (n = 6), and 4-month-old (n = 6) Montofon calves. Plasma concentrations of marbofloxacin were measured using HPLC, and pharmacokinetic data were calculated by non-compartmental analysis. The elimination half-life (t 1/2ʎz ), volume of distribution at steady state (V dss), total clearance (ClT), and area under the concentration-versus time curve (AUC0–∞) values of marbofloxacin in 1-month-old calves were 10.62 h, 1.03 L/kg, 0.08 L/h/kg, and 127.90 h*μg/mL, respectively. While the t 1/2ʎz (from 10.62 to 3.36 h) and AUC0–∞ (from 127.90 to 47.35 h*μg/mL) decreased in parallel with the age of the calves, ClT (from 0.08 to 0.21 L/h/kg) increased. The V dss of marbofloxacin was higher in 1- and 2-month-old calves compared to 4-month-old calves. After IV administration of marbofloxacin at a dose of 10 mg/kg, an ƒAUC0–24/MIC90 ratio of ≥ 125 was obtained for bacteria with MIC90 values of ≤ 0.60, ≤ 0.39 and ≤ 0.27 μg/mL in 1-, 2-, and 4-month-old calves, respectively. These results show that the antibacterial effect of marbofloxacin, which has concentration-dependent activity, decreases due to age-related pharmacokinetic changes and that the 10 mg/kg dose should be reviewed according to the MIC90 value of the bacteria.
Conflicts of Interest
The authors declare no conflicts of interest.
Open Research
Data Availability Statement
The data that support the findings of this study are available from the corresponding author upon reasonable request.
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