Clinical Investigative Study

Heterogeneity of Multiple Sclerosis White Matter Lesions Detected With T2*-Weighted Imaging at 7.0 Tesla

Bing Yao PhD

Advanced Magnetic Resonance Imaging Section Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD

Neuroimaging Center, Kessler Foundation, West Orange, NJ

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Vasiliki N. Ikonomidou PhD,

Vasiliki N. Ikonomidou PhD

Neuroimmunology Branch, NINDS, NIH, Bethesda, MD

Department of Bioengineering, Volgenau School of Engineering, George Mason University, Fairfax, VA

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Fredric K. Cantor MD,

Fredric K. Cantor MD

Neuroimmunology Branch, NINDS, NIH, Bethesda, MD

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Joan M. Ohayon CRNP,

Joan M. Ohayon CRNP

Neuroimmunology Branch, NINDS, NIH, Bethesda, MD

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Jeff Duyn PhD,

Jeff Duyn PhD

Advanced Magnetic Resonance Imaging Section Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD

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Francesca Bagnato MD, PhD,

Corresponding Author

Francesca Bagnato MD, PhD

Neuroimmunology Branch, NINDS, NIH, Bethesda, MD

Neurology Department, University of Maryland, Baltimore, MD

Correspondence: Address correspondence to Francesca Bagnato, MD, PhD, Department of Neurology, University of Maryland, 110 S, Paca Street, Baltimore, MD 21201. E-mail: [email protected].Search for more papers by this author

Bing Yao PhD,

Bing Yao PhD

Advanced Magnetic Resonance Imaging Section Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD

Neuroimaging Center, Kessler Foundation, West Orange, NJ

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Vasiliki N. Ikonomidou PhD,

Vasiliki N. Ikonomidou PhD

Neuroimmunology Branch, NINDS, NIH, Bethesda, MD

Department of Bioengineering, Volgenau School of Engineering, George Mason University, Fairfax, VA

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Fredric K. Cantor MD,

Fredric K. Cantor MD

Neuroimmunology Branch, NINDS, NIH, Bethesda, MD

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Joan M. Ohayon CRNP,

Joan M. Ohayon CRNP

Neuroimmunology Branch, NINDS, NIH, Bethesda, MD

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Jeff Duyn PhD,

Jeff Duyn PhD

Advanced Magnetic Resonance Imaging Section Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD

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Francesca Bagnato MD, PhD,

Corresponding Author

Francesca Bagnato MD, PhD

Neuroimmunology Branch, NINDS, NIH, Bethesda, MD

Neurology Department, University of Maryland, Baltimore, MD

First published: 06 February 2015

https://doi.org/10.1111/jon.12193

Citations: 30

Conflicts of Interest: None of the authors has any conflicts with the work.

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ABSTRACT

BACKGROUND AND PURPOSE

Postmortem studies in multiple sclerosis (MS) indicate that in some white matter lesions (WM-Ls), iron is detectable with T₂*-weighted (T₂*-w), and its reciprocal R₂* relaxation rate, magnetic resonance imaging (MRI) at 7.0 Tesla (7T). This iron appears as a hyperintense rim in R₂* images surrounding a hypointense core. We describe how this observation relates to clinical/radiological characteristics of patients, in vivo.

METHODS

We imaged 16 MS patients using 3T and 7T scanners. WM-Ls were identified on T₁-w/T₂-w 3T-MRIs. Thereafter, WM-Ls with a rim of elevated R₂* at 7T were counted and compared to their appearance on conventional MRIs.

RESULTS

We counted 36 WM-Ls presenting a rim of elevated R₂* in 10 patients. Twenty-three (64%) lesions coincided with focal WM-Ls on T₂-w MRIs; 13 (36%) coincided with only portions of larger lesions on T₂-w images; and 20 (56%) corresponded to a hypointense chronic black hole. WM-Ls presenting a rim of elevated R₂* were seen in both relapsing-remitting patients with low disability and in those with long-standing secondary progressive MS.

CONCLUSIONS

WM-Ls with a contour of high R₂* are present at different MS stages, potentially representing differences in the contribution of iron in MS disease evolution.

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Volume25, Issue5

September/October 2015

Pages 799-806

Heterogeneity of Multiple Sclerosis White Matter Lesions Detected With T2*-Weighted Imaging at 7.0 Tesla

ABSTRACT

BACKGROUND AND PURPOSE

METHODS

RESULTS

CONCLUSIONS

References

Citing Literature

References

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Heterogeneity of Multiple Sclerosis White Matter Lesions Detected With T2*-Weighted Imaging at 7.0 Tesla

ABSTRACT

BACKGROUND AND PURPOSE

METHODS

RESULTS

CONCLUSIONS

References

Citing Literature

References

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