Clinical Investigative Study

Optic Neuritis and the Visual Pathway: Evaluation of Neuromyelitis Optica Spectrum by Resting-State fMRI and Diffusion Tensor MRI

Corresponding Author

Fernanda Cristina Rueda Lopes MD, MSc

Federal University of Rio de Janeiro, Radiology, Rua Presidente João Pessoa, Niterói, Rio de Janeiro, Brazil

Correspondence: Address correspondence to Fernanda C Rueda Lopes, Federal University of Rio de Janeiro, Radiology, Rua Presidente João Pessoa, 385/704, Niterói, Rio de Janeiro, Brazil, 24220-330. E-mail: [email protected].Search for more papers by this author

Soniza Vieira Alves-Leon MD, PhD,

Soniza Vieira Alves-Leon MD, PhD

Federal University of Rio de Janeiro, Neurology, Rio de Janeiro, Rio de Janeiro, Brazil

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Jose Mauricio Godoy MD,

Jose Mauricio Godoy MD

State University of Rio de Janeiro, Neurology, Rio de Janeiro, Rio de Janeiro, Brazil

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Simone de Souza Batista Scherpenhuijzen MD,

Simone de Souza Batista Scherpenhuijzen MD

State University of Rio de Janeiro, Neurology, Rio de Janeiro, Rio de Janeiro, Brazil

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Leticia Fezer MD,

Leticia Fezer MD

State University of Rio de Janeiro, Neurology, Rio de Janeiro, Rio de Janeiro, Brazil

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Emerson Leandro Gasparetto MD, PhD,

Emerson Leandro Gasparetto MD, PhD

Federal University of Rio de Janeiro, Radiology, Rua Presidente João Pessoa, Niterói, Rio de Janeiro, Brazil

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Fernanda Cristina Rueda Lopes MD, MSc,

Corresponding Author

Fernanda Cristina Rueda Lopes MD, MSc

Federal University of Rio de Janeiro, Radiology, Rua Presidente João Pessoa, Niterói, Rio de Janeiro, Brazil

Soniza Vieira Alves-Leon MD, PhD,

Soniza Vieira Alves-Leon MD, PhD

Federal University of Rio de Janeiro, Neurology, Rio de Janeiro, Rio de Janeiro, Brazil

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Jose Mauricio Godoy MD,

Jose Mauricio Godoy MD

State University of Rio de Janeiro, Neurology, Rio de Janeiro, Rio de Janeiro, Brazil

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Simone de Souza Batista Scherpenhuijzen MD,

Simone de Souza Batista Scherpenhuijzen MD

State University of Rio de Janeiro, Neurology, Rio de Janeiro, Rio de Janeiro, Brazil

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Leticia Fezer MD,

Leticia Fezer MD

State University of Rio de Janeiro, Neurology, Rio de Janeiro, Rio de Janeiro, Brazil

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Emerson Leandro Gasparetto MD, PhD,

Emerson Leandro Gasparetto MD, PhD

Federal University of Rio de Janeiro, Radiology, Rua Presidente João Pessoa, Niterói, Rio de Janeiro, Brazil

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First published: 15 January 2015

https://doi.org/10.1111/jon.12191

Citations: 13

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ABSTRACT

BACKGROUND AND PURPOSE

Optic neuritis (ON) is an acute episode of inflammation in the visual pathway (VP). It may occur as part of a demyelinating disease, which can affect white matter (WM) throughout the VP. Compensatory cortical adaptations may occur following WM damage to maintain visual integrity. Our aim was to investigate whether resting-state functional MRI (rsfMRI) can detect cortical adaptations following ON attacks and to correlate rsfMRI with diffusion tensor imaging (DTI) of WM within the VP.

MATERIALS AND METHODS

Neuromyelitis optica spectrum patients were compared to healthy controls at least 6 months after ON onset. DTI and rsfMRI were performed and post-processed using FSL tools (TBSS for DTI and MELODIC for fMRI).

RESULTS

Ptients had higher synchronization values than controls in the visual network (3.48 vs. 2.12, P < .05). A weak trend of correlation was revealed between fMRI and structural analysis by DTI using fractional anisotropy (right side: R = −.36, P < .08; left side: R = .075, P < .73).

CONCLUSIONS

The rsfMRI detected cortical reorganization following ON attack, but WM was considerably preserved in the posterior VP.

References

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Citing Literature

Volume25, Issue5

September/October 2015

Pages 807-812

Optic Neuritis and the Visual Pathway: Evaluation of Neuromyelitis Optica Spectrum by Resting-State fMRI and Diffusion Tensor MRI

ABSTRACT

BACKGROUND AND PURPOSE

MATERIALS AND METHODS

RESULTS

CONCLUSIONS

References

Citing Literature

References

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Optic Neuritis and the Visual Pathway: Evaluation of Neuromyelitis Optica Spectrum by Resting-State fMRI and Diffusion Tensor MRI

ABSTRACT

BACKGROUND AND PURPOSE

MATERIALS AND METHODS

RESULTS

CONCLUSIONS

References

Citing Literature

References

Related

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