Role of exosomes in skin diseases
Corresponding Author
Aysenur Botsali MD
Department of Dermatology, Gülhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey
Correspondence
Ayşenur Botsalı, Department of Dermatology, Gülhane Training and Research Hospital, University of Health Sciences, General Dr. Tevfik Saglam Cd. SBÜ Gülhane EAH Dermatoloji AD Etlik, Ankara, Turkey.
Email: [email protected]
Search for more papers by this authorErcan Caliskan MD
Department of Dermatology, Gülhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey
Search for more papers by this authorCorresponding Author
Aysenur Botsali MD
Department of Dermatology, Gülhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey
Correspondence
Ayşenur Botsalı, Department of Dermatology, Gülhane Training and Research Hospital, University of Health Sciences, General Dr. Tevfik Saglam Cd. SBÜ Gülhane EAH Dermatoloji AD Etlik, Ankara, Turkey.
Email: [email protected]
Search for more papers by this authorErcan Caliskan MD
Department of Dermatology, Gülhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey
Search for more papers by this authorAbstract
Background
Exosomes, as a family member of extracellular vesicles, are cell-secreted nanoscale structures that play pivotal roles in regulating physiological and pathophysiological processes of the skin. Exosomes induce communication between cells and are responsible for transporting cellular components such as microRNAs, mRNAs, DNA, lipids, metabolites, and cell-surface proteins. Numerous preclinical and clinical trials searched the contribution of exosomes to skin functions and disorders. Thus, exosomes are gaining increasing attention within investigational dermatology. In advance, stem-cell-derived exosomes were integrated into the functional cosmetics industry nominated as cell-free regenerative medicine.
Objective
This review aims to demonstrate the roles of exosomes in inflammatory skin disorders, stem cell, and tumor biology through a comprehensive evaluation of the diagnostic, prognostic, and therapeutic perspectives.
Methods
A comprehensive literature search was performed using electronic online databases "PubMed" and "Google Scholar" using key words ''exosomes'', ''skin'', ''wound healing''.
Conclusion
Exosomes are regarded as promising diagnostic and prognostic biomarkers for various skin diseases. Future prospects are repurposing exosomes to treat skin disorders, either as drug carriers or drugs themselves.
CONFLICT OF INTEREST
The authors declared that there is no conflict of interest.
Open Research
DATA AVAILABILITY STATEMENT
The data that support the findings of this study are available from the corresponding author upon reasonable request.
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