Detection of Mycobacterium avium subsp. paratuberculosis in non-human primates
Kim Fechner
Division of Microbiology and Animal Hygiene, Department of Animal Sciences, Faculty of Agricultural Sciences, University of Goettingen, Göttingen, Germany
Search for more papers by this authorKerstin Mätz-Rensing
Pathology Unit, German Primate Center (DPZ), Göttingen, Germany
Search for more papers by this authorKaren Lampe
Pathology Unit, German Primate Center (DPZ), Göttingen, Germany
Search for more papers by this authorFranz-Josef Kaup
Pathology Unit, German Primate Center (DPZ), Göttingen, Germany
Search for more papers by this authorClaus-Peter Czerny
Division of Microbiology and Animal Hygiene, Department of Animal Sciences, Faculty of Agricultural Sciences, University of Goettingen, Göttingen, Germany
Search for more papers by this authorCorresponding Author
Jenny Schäfer
Division of Microbiology and Animal Hygiene, Department of Animal Sciences, Faculty of Agricultural Sciences, University of Goettingen, Göttingen, Germany
Correspondence
Jenny Schäfer, Department of Animal Sciences, University of Goettingen, Göttingen, Germany.
Email: [email protected]
Search for more papers by this authorKim Fechner
Division of Microbiology and Animal Hygiene, Department of Animal Sciences, Faculty of Agricultural Sciences, University of Goettingen, Göttingen, Germany
Search for more papers by this authorKerstin Mätz-Rensing
Pathology Unit, German Primate Center (DPZ), Göttingen, Germany
Search for more papers by this authorKaren Lampe
Pathology Unit, German Primate Center (DPZ), Göttingen, Germany
Search for more papers by this authorFranz-Josef Kaup
Pathology Unit, German Primate Center (DPZ), Göttingen, Germany
Search for more papers by this authorClaus-Peter Czerny
Division of Microbiology and Animal Hygiene, Department of Animal Sciences, Faculty of Agricultural Sciences, University of Goettingen, Göttingen, Germany
Search for more papers by this authorCorresponding Author
Jenny Schäfer
Division of Microbiology and Animal Hygiene, Department of Animal Sciences, Faculty of Agricultural Sciences, University of Goettingen, Göttingen, Germany
Correspondence
Jenny Schäfer, Department of Animal Sciences, University of Goettingen, Göttingen, Germany.
Email: [email protected]
Search for more papers by this authorAbstract
Background
Due to a sporadic occurrence of Mycobacterium avium subsp. paratuberculosis (MAP) in non-human primates (NHP), the susceptibility of different NHP to MAP should be investigated.
Methods
Fecal and tissue samples (ileum, ileocecal lymph node, bone marrow) of 20 animals (seven species) were analyzed by IS900-based PCRs and sequenced. Samples of MAP PCR positive NHP were further cultivated.
Results
MAP DNA was detectable in two animals; the ileum of a cottontop tamarin and the bone marrow of a common marmoset. Cultivation of MAP failed. Sequence analysis revealed 100% homology to the MAP-K10 sequence. Pathohistological examinations offered no direct correlation to a MAP infection.
Conclusions
MAP was detected for the first time in a common marmoset. But as both NHP suffered from other diseases, an asymptomatic infection with MAP was assumed. The detection of MAP in the bone marrow might play a role in establishing latent paratuberculosis, as known from tuberculosis.
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