Incidence and clinical characteristics of inflammatory bowel disease in a developed region of Guangdong Province, China: A prospective population-based study
Zhirong Zeng
Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
Potential competing interests: None.Search for more papers by this authorZhenhua Zhu
Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
Potential competing interests: None.Search for more papers by this authorYuyu Yang
Department of Gastroenterology, Zhongshan People's Hospital, Zhongshan, Guangdong, China
Search for more papers by this authorWeishan Ruan
Department of Gastroenterology, Zhongshan People's Hospital, Zhongshan, Guangdong, China
Search for more papers by this authorXiabiao Peng
Department of Gastroenterology, Zhongshan People's Hospital, Zhongshan, Guangdong, China
Search for more papers by this authorYuhuan Su
Anorectal Department, Zhongshan Hospital of Traditional Chinese Medicine, Zhongshan, Guangdong, China
Search for more papers by this authorLin Peng
Anorectal Department, Zhongshan Hospital of Traditional Chinese Medicine, Zhongshan, Guangdong, China
Search for more papers by this authorJinquan Chen
Anorectal Department, Zhongshan Hospital of Traditional Chinese Medicine, Zhongshan, Guangdong, China
Search for more papers by this authorQuan Yin
Department of Gastroenterology, Zhongshan Boai Hospital, Zhongshan, Guangdong, China
Search for more papers by this authorChao Zhao
Department of Gastroenterology, Zhongshan Boai Hospital, Zhongshan, Guangdong, China
Search for more papers by this authorHaihua Zhou
Department of Gastroenterology, Zhongshan Xiaolan Hospital, Zhongshan, Guangdong, China
Search for more papers by this authorShuai Yuan
Department of Gastroenterology, Zhongshan Xiaolan Hospital, Zhongshan, Guangdong, China
Search for more papers by this authorYuantao Hao
School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China
Search for more papers by this authorJiaming Qian
Department of Gastroenterology, Peking Union Medical College Hospital, Beijing, China
Search for more papers by this authorSiew Chien Ng
Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Science, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, China
Search for more papers by this authorMinhu Chen
Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
Search for more papers by this authorCorresponding Author
Pinjin Hu
Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
Correspondence
Professor Pinjin Hu and Professor Minhu Chen, Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong, China. Email: [email protected] or [email protected]
Search for more papers by this authorZhirong Zeng
Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
Potential competing interests: None.Search for more papers by this authorZhenhua Zhu
Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
Potential competing interests: None.Search for more papers by this authorYuyu Yang
Department of Gastroenterology, Zhongshan People's Hospital, Zhongshan, Guangdong, China
Search for more papers by this authorWeishan Ruan
Department of Gastroenterology, Zhongshan People's Hospital, Zhongshan, Guangdong, China
Search for more papers by this authorXiabiao Peng
Department of Gastroenterology, Zhongshan People's Hospital, Zhongshan, Guangdong, China
Search for more papers by this authorYuhuan Su
Anorectal Department, Zhongshan Hospital of Traditional Chinese Medicine, Zhongshan, Guangdong, China
Search for more papers by this authorLin Peng
Anorectal Department, Zhongshan Hospital of Traditional Chinese Medicine, Zhongshan, Guangdong, China
Search for more papers by this authorJinquan Chen
Anorectal Department, Zhongshan Hospital of Traditional Chinese Medicine, Zhongshan, Guangdong, China
Search for more papers by this authorQuan Yin
Department of Gastroenterology, Zhongshan Boai Hospital, Zhongshan, Guangdong, China
Search for more papers by this authorChao Zhao
Department of Gastroenterology, Zhongshan Boai Hospital, Zhongshan, Guangdong, China
Search for more papers by this authorHaihua Zhou
Department of Gastroenterology, Zhongshan Xiaolan Hospital, Zhongshan, Guangdong, China
Search for more papers by this authorShuai Yuan
Department of Gastroenterology, Zhongshan Xiaolan Hospital, Zhongshan, Guangdong, China
Search for more papers by this authorYuantao Hao
School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China
Search for more papers by this authorJiaming Qian
Department of Gastroenterology, Peking Union Medical College Hospital, Beijing, China
Search for more papers by this authorSiew Chien Ng
Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Science, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, China
Search for more papers by this authorMinhu Chen
Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
Search for more papers by this authorCorresponding Author
Pinjin Hu
Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
Correspondence
Professor Pinjin Hu and Professor Minhu Chen, Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong, China. Email: [email protected] or [email protected]
Search for more papers by this authorAbstract
Background and Aims
The incidence of inflammatory bowel disease (IBD) is increasing in China with urbanization and socioeconomic development. There is however a lack of prospective, population-based epidemiology study on IBD in China. The aim of the study is to define the incidence and clinical characteristics of IBD in a developed region of Guangdong Province in China.
Methods
A prospective, population-based incidence study was conducted from July 2011 to June 2012 in Zhongshan, Guangdong, China. All newly diagnosed IBD cases in Zhongshan were included.
Results
In total, 48 new cases of IBD (17 Crohn's disease [CD]; 31 ulcerative colitis [UC]) were identified over a 1-year period from July 2011. Age-standardized incidence rates for IBD, UC, and CD were 3.14, 2.05, and 1.09 per 100 000 persons, respectively. The median age of UC was 38, and that of CD was 25. Terminal ileum involvement only (L1), isolated colonic disease (L2), and ileocolonic disease (L3) were reported in 24%, 6%, and 71% of patients with CD, respectively. Twenty-four percent of patients had coexisting upper gastrointestinal disease (L4). Inflammatory (B1), stricturing (B2), and penetrating (B3) behavior were seen in 65%, 24%, and 12% of CD patients, respectively. Fifty-nine percent of CD and 26% of UC patients had extra-intestinal manifestations.
Conclusions
This is the first prospective, population-based IBD epidemiological study in a developed region of China. The incidence of IBD is similar to that in Japan and Hong Kong but lower than that in South Korea and Western countries.
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