Pocket resolution in regenerative treatment of intrabony defects with papilla preservation techniques: A systematic review and meta-analysis of randomized clinical trials
Corresponding Author
Mario Aimetti
Department of Surgical Sciences, C.I.R. Dental School, Section of Periodontology, University of Turin, Turin, Italy
Correspondence
Mario Aimetti, C.I.R. Dental School, Section of Periodontology, Via Nizza 230, Turin 10126, Italy.
Email: [email protected]
Search for more papers by this authorAdriano Fratini
Department of Surgical Sciences, C.I.R. Dental School, Section of Periodontology, University of Turin, Turin, Italy
Search for more papers by this authorMarta Giraudi
Department of Surgical Sciences, C.I.R. Dental School, Section of Periodontology, University of Turin, Turin, Italy
Search for more papers by this authorFilippo Citterio
Department of Surgical Sciences, C.I.R. Dental School, Section of Periodontology, University of Turin, Turin, Italy
Search for more papers by this authorFrancesco Ferrarotti
Department of Surgical Sciences, C.I.R. Dental School, Section of Periodontology, University of Turin, Turin, Italy
Search for more papers by this authorGiulia Maria Mariani
Department of Surgical Sciences, C.I.R. Dental School, Section of Periodontology, University of Turin, Turin, Italy
Search for more papers by this authorFrancesco Cairo
Department of Experimental and Clinical Medicine, Research Unit in Periodontology and Periodontal Medicine, University of Florence, Florence, Italy
Search for more papers by this authorGiacomo Baima
Department of Surgical Sciences, C.I.R. Dental School, Section of Periodontology, University of Turin, Turin, Italy
Search for more papers by this authorFederica Romano
Department of Surgical Sciences, C.I.R. Dental School, Section of Periodontology, University of Turin, Turin, Italy
Search for more papers by this authorCorresponding Author
Mario Aimetti
Department of Surgical Sciences, C.I.R. Dental School, Section of Periodontology, University of Turin, Turin, Italy
Correspondence
Mario Aimetti, C.I.R. Dental School, Section of Periodontology, Via Nizza 230, Turin 10126, Italy.
Email: [email protected]
Search for more papers by this authorAdriano Fratini
Department of Surgical Sciences, C.I.R. Dental School, Section of Periodontology, University of Turin, Turin, Italy
Search for more papers by this authorMarta Giraudi
Department of Surgical Sciences, C.I.R. Dental School, Section of Periodontology, University of Turin, Turin, Italy
Search for more papers by this authorFilippo Citterio
Department of Surgical Sciences, C.I.R. Dental School, Section of Periodontology, University of Turin, Turin, Italy
Search for more papers by this authorFrancesco Ferrarotti
Department of Surgical Sciences, C.I.R. Dental School, Section of Periodontology, University of Turin, Turin, Italy
Search for more papers by this authorGiulia Maria Mariani
Department of Surgical Sciences, C.I.R. Dental School, Section of Periodontology, University of Turin, Turin, Italy
Search for more papers by this authorFrancesco Cairo
Department of Experimental and Clinical Medicine, Research Unit in Periodontology and Periodontal Medicine, University of Florence, Florence, Italy
Search for more papers by this authorGiacomo Baima
Department of Surgical Sciences, C.I.R. Dental School, Section of Periodontology, University of Turin, Turin, Italy
Search for more papers by this authorFederica Romano
Department of Surgical Sciences, C.I.R. Dental School, Section of Periodontology, University of Turin, Turin, Italy
Search for more papers by this authorAbstract
Aim
To systematically assess the clinical performance of different approaches for periodontal regeneration of intrabony defects in terms of pocket resolution compared to access surgery with papilla preservation techniques (PPTs).
Material and Methods
Systematic literature searches were conducted on PubMed, EMBASE, and CENTRAL up to April 2020 to identify RCTs on regenerative treatment [guided tissue regeneration (GTR) or enamel matrix derivative (EMD) with or without biomaterials] of intrabony defects using PPTs. Results were expressed as weighted mean percentages (WMP) or risk ratios of pocket resolution at 12 months (considering both final PD ≤ 3 mm and ≤4 mm).
Results
A total of 12 RCTs were included. Based on a final PD ≤ 3 mm or PD ≤ 4 mm, the WMP of pocket resolution was 61.4% and 92.1%, respectively. EMD and GTR obtained comparable results. Pairwise meta-analysis identified a greater probability of achieving pocket resolution for GTR compared to PPTs. The number needed to treat for GTR to obtain one extra intrabony defect achieving PD ≤ 3 mm or PD ≤ 4 mm over PPTs was 2 and 4, respectively.
Conclusion
Regenerative surgery represents a viable approach to obtain final PD ≤ 4 mm in the short-term.
CONFLICT OF INTEREST
The authors report no conflicts of interest related to this study. There was no external funding for this study.
Supporting Information
| Filename | Description |
|---|---|
| jcpe13428-sup-0001-TableS1.pdfPDF document, 64.4 KB | Table S1 |
| jcpe13428-sup-0002-TableS2.docxWord document, 92.6 KB | Table S2 |
| jcpe13428-sup-0003-TableS3.docxWord document, 499.3 KB | Table S3 |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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