Position of Double Bond of Trans Isomers of Linoleic Acid Affects Fatty Acid Desaturation and Elongation
Abstract
The position of the trans double bond of linoleic acid isomers affects the incorporation of the isomers in tissue lipids and their metabolic conversion to other metabolites. The 9 trans, 12 cis isomer of linoleic acid is a poor substrate and the 9 cis, 12 trans isomer is a good substrate for the enzyme that desaturates dienoic acids at position six.