Catalytic mechanisms, basic roles, and biotechnological and environmental significance of halogenating enzymes
Xianping Chen,
Karl-Heinz Van Pée,
Xianping Chen
The Biomedical Engineering Centre, Guilin University of Electronic Technology, Guilin 541004, China
The Institute of Biochemistry, Dresden University of Technology, Dresden 01062, Germany
Search for more papers by this authorCorresponding Author
Karl-Heinz Van Pée
The Institute of Biochemistry, Dresden University of Technology, Dresden 01062, Germany
*Corresponding author: Tel, 49-351-46334494; Fax, 49-351-46335506; E-mail, [email protected]Search for more papers by this authorXianping Chen,
Karl-Heinz Van Pée,
Xianping Chen
The Biomedical Engineering Centre, Guilin University of Electronic Technology, Guilin 541004, China
The Institute of Biochemistry, Dresden University of Technology, Dresden 01062, Germany
Search for more papers by this authorCorresponding Author
Karl-Heinz Van Pée
The Institute of Biochemistry, Dresden University of Technology, Dresden 01062, Germany
*Corresponding author: Tel, 49-351-46334494; Fax, 49-351-46335506; E-mail, [email protected]Search for more papers by this authorAbstract
The understanding of enzymatic incorporation of halogen atoms into organic molecules has increased during the last few years. Two novel types of halogenating enzymes, flavindependent halogenases and α-ketoglutarate-dependent halogenases, are now known to play a significant role in enzyme-catalyzed halogenation. The recent advances on the halogenating enzymes RebH, SyrB2, and CytC3 have suggested some new mechanisms for enzymatic halogenations. This review concentrates on the occurrence, catalytic mechanisms, and biotechnological applications of the halogenating enzymes that are currently known.
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