Endothelial Nitric Oxide Synthase Gene Intron 4, 27 bp Repeat Polymorphism and Essential Hypertension in the Kazakh Chinese Population
Fengmei DENG
West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610044, China
Search for more papers by this authorQinghua HU
Key Laboratory of Xinjiang Endemic and Ethnic Diseases Cooperated by Education Ministry with Xinjiang Province, College of Medicine, Shihezi University, Shihezi 832002, China
Key Laboratory for Respiratory Diseases, Health Ministry of China, Wuhan 430030, China
Search for more papers by this authorBin TANG
First Affiliated Hospital, College of Medicine, Shihezi University, Shihezi 832008, China
Search for more papers by this authorFang HE
Key Laboratory of Xinjiang Endemic and Ethnic Diseases Cooperated by Education Ministry with Xinjiang Province, College of Medicine, Shihezi University, Shihezi 832002, China
Key Laboratory for Respiratory Diseases, Health Ministry of China, Wuhan 430030, China
Search for more papers by this authorShuxia GUO
Key Laboratory of Xinjiang Endemic and Ethnic Diseases Cooperated by Education Ministry with Xinjiang Province, College of Medicine, Shihezi University, Shihezi 832002, China
Search for more papers by this authorJiang CHEN
First Affiliated Hospital, College of Medicine, Shihezi University, Shihezi 832008, China
Search for more papers by this authorFeng LI
Key Laboratory of Xinjiang Endemic and Ethnic Diseases Cooperated by Education Ministry with Xinjiang Province, College of Medicine, Shihezi University, Shihezi 832002, China
Search for more papers by this authorXuehua WU
Key Laboratory of Xinjiang Endemic and Ethnic Diseases Cooperated by Education Ministry with Xinjiang Province, College of Medicine, Shihezi University, Shihezi 832002, China
Search for more papers by this authorJun ZHANG
Key Laboratory of Xinjiang Endemic and Ethnic Diseases Cooperated by Education Ministry with Xinjiang Province, College of Medicine, Shihezi University, Shihezi 832002, China
Search for more papers by this authorHuimin ZHANG
Key Laboratory of Xinjiang Endemic and Ethnic Diseases Cooperated by Education Ministry with Xinjiang Province, College of Medicine, Shihezi University, Shihezi 832002, China
Search for more papers by this authorJuan ZHAO
Key Laboratory of Xinjiang Endemic and Ethnic Diseases Cooperated by Education Ministry with Xinjiang Province, College of Medicine, Shihezi University, Shihezi 832002, China
Search for more papers by this authorHua ZHONG
Key Laboratory of Xinjiang Endemic and Ethnic Diseases Cooperated by Education Ministry with Xinjiang Province, College of Medicine, Shihezi University, Shihezi 832002, China
Search for more papers by this authorLing HE
Key Laboratory of Xinjiang Endemic and Ethnic Diseases Cooperated by Education Ministry with Xinjiang Province, College of Medicine, Shihezi University, Shihezi 832002, China
Search for more papers by this authorJun LI
Key Laboratory of Xinjiang Endemic and Ethnic Diseases Cooperated by Education Ministry with Xinjiang Province, College of Medicine, Shihezi University, Shihezi 832002, China
Search for more papers by this authorLe ZHANG
West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610044, China
Key Laboratory of Xinjiang Endemic and Ethnic Diseases Cooperated by Education Ministry with Xinjiang Province, College of Medicine, Shihezi University, Shihezi 832002, China
Search for more papers by this authorCorresponding Author
Shuren WANG
West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610044, China
*Corresponding author: Tel, 86-28 -85 501 26 8; E-mail, [email protected]Search for more papers by this authorFengmei DENG
West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610044, China
Search for more papers by this authorQinghua HU
Key Laboratory of Xinjiang Endemic and Ethnic Diseases Cooperated by Education Ministry with Xinjiang Province, College of Medicine, Shihezi University, Shihezi 832002, China
Key Laboratory for Respiratory Diseases, Health Ministry of China, Wuhan 430030, China
Search for more papers by this authorBin TANG
First Affiliated Hospital, College of Medicine, Shihezi University, Shihezi 832008, China
Search for more papers by this authorFang HE
Key Laboratory of Xinjiang Endemic and Ethnic Diseases Cooperated by Education Ministry with Xinjiang Province, College of Medicine, Shihezi University, Shihezi 832002, China
Key Laboratory for Respiratory Diseases, Health Ministry of China, Wuhan 430030, China
Search for more papers by this authorShuxia GUO
Key Laboratory of Xinjiang Endemic and Ethnic Diseases Cooperated by Education Ministry with Xinjiang Province, College of Medicine, Shihezi University, Shihezi 832002, China
Search for more papers by this authorJiang CHEN
First Affiliated Hospital, College of Medicine, Shihezi University, Shihezi 832008, China
Search for more papers by this authorFeng LI
Key Laboratory of Xinjiang Endemic and Ethnic Diseases Cooperated by Education Ministry with Xinjiang Province, College of Medicine, Shihezi University, Shihezi 832002, China
Search for more papers by this authorXuehua WU
Key Laboratory of Xinjiang Endemic and Ethnic Diseases Cooperated by Education Ministry with Xinjiang Province, College of Medicine, Shihezi University, Shihezi 832002, China
Search for more papers by this authorJun ZHANG
Key Laboratory of Xinjiang Endemic and Ethnic Diseases Cooperated by Education Ministry with Xinjiang Province, College of Medicine, Shihezi University, Shihezi 832002, China
Search for more papers by this authorHuimin ZHANG
Key Laboratory of Xinjiang Endemic and Ethnic Diseases Cooperated by Education Ministry with Xinjiang Province, College of Medicine, Shihezi University, Shihezi 832002, China
Search for more papers by this authorJuan ZHAO
Key Laboratory of Xinjiang Endemic and Ethnic Diseases Cooperated by Education Ministry with Xinjiang Province, College of Medicine, Shihezi University, Shihezi 832002, China
Search for more papers by this authorHua ZHONG
Key Laboratory of Xinjiang Endemic and Ethnic Diseases Cooperated by Education Ministry with Xinjiang Province, College of Medicine, Shihezi University, Shihezi 832002, China
Search for more papers by this authorLing HE
Key Laboratory of Xinjiang Endemic and Ethnic Diseases Cooperated by Education Ministry with Xinjiang Province, College of Medicine, Shihezi University, Shihezi 832002, China
Search for more papers by this authorJun LI
Key Laboratory of Xinjiang Endemic and Ethnic Diseases Cooperated by Education Ministry with Xinjiang Province, College of Medicine, Shihezi University, Shihezi 832002, China
Search for more papers by this authorLe ZHANG
West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610044, China
Key Laboratory of Xinjiang Endemic and Ethnic Diseases Cooperated by Education Ministry with Xinjiang Province, College of Medicine, Shihezi University, Shihezi 832002, China
Search for more papers by this authorCorresponding Author
Shuren WANG
West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610044, China
*Corresponding author: Tel, 86-28 -85 501 26 8; E-mail, [email protected]Search for more papers by this authorAbstract
To investigate the relationship between 27 bp repeat polymorphism in intron 4 in the endothelial nitric oxide synthase (eNOS4) gene and essential hypertension in the Kazakh Chinese population, 151 patients with essential hypertension and 138 healthy people were selected from the Boertonggu countryside of Shawan region in the Xinjiang Uygur Autonomous Region of China in 2006. The polymorphism of eNOS in the two groups was detected with polymerase chain reaction assays and the genotype frequencies in each group were calculated following the Hardy-Weinberg law. Four and five tandem 27 bp repeats were designated as “a” and “b”, respectively. It was found that the frequencies of b/b, b/a and a/a genotypes of the eNOS4 gene were 84.06%, 15.22% and 0.72% in the control group, and 81.46%, 15.89% and 2.65% in the hypertension group, respectively. The frequencies of gene “b” and “a” were 91.67% and 8.33% in the control group and 89.40% and 10.60% in the hypertension group, respectively. It was found that plasma eNOS activity was not associated with genotypes and alleles of eNOS gene. Plasma eNOS activity in the hypertension group was significantly decreased compared with the control group (P<0.01). The results suggest that eNOS4 gene polymorphisms are unlikely to be the major genetic susceptibility factors for essential hypertension in the Xinjiang Kazakh population. However, a positive association between plasma eNOS activity and essential hypertension has been revealed.
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