Volume 100, Issue 5 pp. 728-731

REGULAR ARTICLE

Clinical accuracy of anti-tissue transglutaminase as screening test for celiac disease under 2 years

Fabio Panetta,

Fabio Panetta

Hepatology, Gastroenterology and Nutrition Unit, Bambino Gesù Children’s Hospital-Rome, Rome, Italy

PhD Fellowship, University Hospital “G. Martino”, Messina, Italy

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Giuliano Torre,

Giuliano Torre

Hepatology, Gastroenterology and Nutrition Unit, Bambino Gesù Children’s Hospital-Rome, Rome, Italy

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Franco Colistro,

Franco Colistro

Biochemistry Laboratory, Bambino Gesù Children’s Hospital-Rome, Rome, Italy

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Francesca Ferretti,

Francesca Ferretti

Hepatology, Gastroenterology and Nutrition Unit, Bambino Gesù Children’s Hospital-Rome, Rome, Italy

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Antonella Daniele,

Antonella Daniele

Hepatology, Gastroenterology and Nutrition Unit, Bambino Gesù Children’s Hospital-Rome, Rome, Italy

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Antonella Diamanti,

Antonella Diamanti

Hepatology, Gastroenterology and Nutrition Unit, Bambino Gesù Children’s Hospital-Rome, Rome, Italy

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Fabio Panetta,

Fabio Panetta

Hepatology, Gastroenterology and Nutrition Unit, Bambino Gesù Children’s Hospital-Rome, Rome, Italy

PhD Fellowship, University Hospital “G. Martino”, Messina, Italy

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Giuliano Torre,

Giuliano Torre

Hepatology, Gastroenterology and Nutrition Unit, Bambino Gesù Children’s Hospital-Rome, Rome, Italy

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Franco Colistro,

Franco Colistro

Biochemistry Laboratory, Bambino Gesù Children’s Hospital-Rome, Rome, Italy

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Francesca Ferretti,

Francesca Ferretti

Hepatology, Gastroenterology and Nutrition Unit, Bambino Gesù Children’s Hospital-Rome, Rome, Italy

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Antonella Daniele,

Antonella Daniele

Hepatology, Gastroenterology and Nutrition Unit, Bambino Gesù Children’s Hospital-Rome, Rome, Italy

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Antonella Diamanti,

Antonella Diamanti

Hepatology, Gastroenterology and Nutrition Unit, Bambino Gesù Children’s Hospital-Rome, Rome, Italy

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First published: 17 December 2010

https://doi.org/10.1111/j.1651-2227.2010.02124.x

Citations: 12

Antonella Diamanti, M.D., Hepathology, Gastroenterology and Nutrition Unit, Bambino Gesù Children’s Hospital, Piazza S. Onofrio, 4 – 00165 Rome, Italy. Tel: +390668592329 |Fax: +390668592876 |Email: [email protected]

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Abstract

Aim: To investigate, in patients with suspected celiac disease (CD) younger than 2 years, the clinical value of anti-tissue transglutaminase (tTG) in diagnostic work-up of CD.

Methods: Between June 2005 and June 2009, 169 patients aged <2 years, with symptoms suggestive of CD, were submitted to biopsy. CD diagnosis was based on the revised criteria of the European Society for Pediatric Gastroenterology, Hepatology and Nutrition.

Results: Of the 169 patients enrolled, 155 were included: 108 of them showed mucosal atrophy and 47 negative histology. Sensitivity and specificity of tTG, at the cut-off of 8 AU/mL, were 0.96 (CI 0.91–0.99) and 0.91 (CI 0.80–0.98), respectively, with likelihood ratio (LR) of 11.31; at the cut-off of 16 AU/mL, they were 0.79 (CI 0.70–0.86) and 1.00, respectively (CI 0.92–1.00), with LR 4.50.

Conclusions: In patients younger than 2 years, suspected for CD, tTG is very valuable in selecting for small intestinal biopsy.

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Volume100, Issue5

May 2011

Pages 728-731

Clinical accuracy of anti-tissue transglutaminase as screening test for celiac disease under 2 years

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Clinical accuracy of anti-tissue transglutaminase as screening test for celiac disease under 2 years

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