Patterns of aluminum hydroxychloride deposition onto the skin

Géraldine Mayeux

Biomedical Science Department, Faculty of Medicine, University Hospital of Liège, Liège, Belgium

Emmanuelle Xhauflaire-Uhoda

Laboratory of Skin Bioengineering and Imaging, Department of Dermatopathology, University Hospital of Liège, Liège, Belgium

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Gérald E. Piérard,

Gérald E. Piérard

Laboratory of Skin Bioengineering and Imaging, Department of Dermatopathology, University Hospital of Liège, Liège, Belgium

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Géraldine Mayeux,

Géraldine Mayeux

Biomedical Science Department, Faculty of Medicine, University Hospital of Liège, Liège, Belgium

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Emmanuelle Xhauflaire-Uhoda,

Emmanuelle Xhauflaire-Uhoda

Laboratory of Skin Bioengineering and Imaging, Department of Dermatopathology, University Hospital of Liège, Liège, Belgium

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Gérald E. Piérard,

Gérald E. Piérard

Laboratory of Skin Bioengineering and Imaging, Department of Dermatopathology, University Hospital of Liège, Liège, Belgium

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First published: 28 March 2011

https://doi.org/10.1111/j.1600-0846.2011.00532.x

Citations: 9

Address:
Gérald E. Piérard
Department of Dermatopathology
CHU Sart Tilman
B-4000 Liége
Belgium
Tel:+32 4 3662408
Fax:+32 4 3662976
e-mail: [email protected]

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Abstract

Background: Aluminum hydroxychloride (AlCl₃) is an antiperspirant.

Aim: To revisit the AlCl₃ deposition in vivo and in vitro on glass slides and stratum corneum (SC) harvested by cyanoacrylate skin surface strippings (CSSS).

Methods: Transepidermal water loss (TEWL) was assessed following application of 5% AlCl₃ on the forearms. The AlCl₃-coated skin, glass slides and CSSS were observed using two ultraviolet light-emitting CCD cameras in order to record changes in specular reflectance related to AlCl₃ deposition. In addition, the corneoxenometry bioassay was performed in order to predict AlCl₃ irritation.

Results: AlCl₃ deposited on glass slides looked as linear threads and rings of similar sizes. AlCl₃ deposits on skin were almost restricted inside the microrelief lines and as annular deposits at their crossings where acrosyringia are opening. After daily AlCl₃ applications, deposits extended on the CSSS plateaus. At rest in absence of sweating, TEWL was decreased following AlCl₃ applications. During physical exercise, the TEWL increase was limited on the AlCl₃ areas. CSSS appeared unreactive to AlCl₃ at the corneoxenometry bioassay.

Conclusion: The similar aspect of AlCl₃ deposits on human SC and on glass slides suggested a physical property of AlCl₃. Repetitive applications of AlCl₃ increased both the deposit area and the barrier function.

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Volume18, Issue1

February 2012

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