Organising pneumonia mimicking invasive fungal disease in patients with leukaemia
Fabio Forghieri
Department of Oncology, Haematology and Respiratory Diseases, Section of Haematology
Search for more papers by this authorLeonardo Potenza
Department of Oncology, Haematology and Respiratory Diseases, Section of Haematology
Search for more papers by this authorMonica Morselli
Department of Oncology, Haematology and Respiratory Diseases, Section of Haematology
Search for more papers by this authorMonica Maccaferri
Department of Oncology, Haematology and Respiratory Diseases, Section of Haematology
Search for more papers by this authorLetizia Pedrazzi
Department of Oncology, Haematology and Respiratory Diseases, Section of Haematology
Search for more papers by this authorPatrizia Barozzi
Department of Oncology, Haematology and Respiratory Diseases, Section of Haematology
Search for more papers by this authorDaniela Vallerini
Department of Oncology, Haematology and Respiratory Diseases, Section of Haematology
Search for more papers by this authorGiovanni Riva
Department of Oncology, Haematology and Respiratory Diseases, Section of Haematology
Search for more papers by this authorEleonora Zanetti
Department of Oncology, Haematology and Respiratory Diseases, Section of Haematology
Search for more papers by this authorChiara Quadrelli
Department of Oncology, Haematology and Respiratory Diseases, Section of Haematology
Search for more papers by this authorGiulio Rossi
Department of Diagnostic and Laboratory Services and Legal Medicine, Section of Pathology
Search for more papers by this authorFrancesco Rivasi
Department of Diagnostic and Laboratory Services and Legal Medicine, Section of Pathology
Search for more papers by this authorMassimino Messino’
Department of Diagnostic and Laboratory Services and Legal Medicine, Microbiology and Virology Unit
Search for more papers by this authorFabio Rumpianesi
Department of Diagnostic and Laboratory Services and Legal Medicine, Microbiology and Virology Unit
Search for more papers by this authorAntonella Grottola
Department of Diagnostic and Laboratory Services and Legal Medicine, Microbiology and Virology Unit
Search for more papers by this authorClaudia Venturelli
Department of Diagnostic and Laboratory Services and Legal Medicine, Microbiology and Virology Unit
Search for more papers by this authorMonica Pecorari
Department of Diagnostic and Laboratory Services and Legal Medicine, Microbiology and Virology Unit
Search for more papers by this authorMauro Codeluppi
Department of Internal Medicine, Section of Infectious Diseases, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria Policlinico, Modena, Italy
Search for more papers by this authorGiuseppe Torelli
Department of Oncology, Haematology and Respiratory Diseases, Section of Haematology
Search for more papers by this authorMario Luppi
Department of Oncology, Haematology and Respiratory Diseases, Section of Haematology
Search for more papers by this authorFabio Forghieri
Department of Oncology, Haematology and Respiratory Diseases, Section of Haematology
Search for more papers by this authorLeonardo Potenza
Department of Oncology, Haematology and Respiratory Diseases, Section of Haematology
Search for more papers by this authorMonica Morselli
Department of Oncology, Haematology and Respiratory Diseases, Section of Haematology
Search for more papers by this authorMonica Maccaferri
Department of Oncology, Haematology and Respiratory Diseases, Section of Haematology
Search for more papers by this authorLetizia Pedrazzi
Department of Oncology, Haematology and Respiratory Diseases, Section of Haematology
Search for more papers by this authorPatrizia Barozzi
Department of Oncology, Haematology and Respiratory Diseases, Section of Haematology
Search for more papers by this authorDaniela Vallerini
Department of Oncology, Haematology and Respiratory Diseases, Section of Haematology
Search for more papers by this authorGiovanni Riva
Department of Oncology, Haematology and Respiratory Diseases, Section of Haematology
Search for more papers by this authorEleonora Zanetti
Department of Oncology, Haematology and Respiratory Diseases, Section of Haematology
Search for more papers by this authorChiara Quadrelli
Department of Oncology, Haematology and Respiratory Diseases, Section of Haematology
Search for more papers by this authorGiulio Rossi
Department of Diagnostic and Laboratory Services and Legal Medicine, Section of Pathology
Search for more papers by this authorFrancesco Rivasi
Department of Diagnostic and Laboratory Services and Legal Medicine, Section of Pathology
Search for more papers by this authorMassimino Messino’
Department of Diagnostic and Laboratory Services and Legal Medicine, Microbiology and Virology Unit
Search for more papers by this authorFabio Rumpianesi
Department of Diagnostic and Laboratory Services and Legal Medicine, Microbiology and Virology Unit
Search for more papers by this authorAntonella Grottola
Department of Diagnostic and Laboratory Services and Legal Medicine, Microbiology and Virology Unit
Search for more papers by this authorClaudia Venturelli
Department of Diagnostic and Laboratory Services and Legal Medicine, Microbiology and Virology Unit
Search for more papers by this authorMonica Pecorari
Department of Diagnostic and Laboratory Services and Legal Medicine, Microbiology and Virology Unit
Search for more papers by this authorMauro Codeluppi
Department of Internal Medicine, Section of Infectious Diseases, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria Policlinico, Modena, Italy
Search for more papers by this authorGiuseppe Torelli
Department of Oncology, Haematology and Respiratory Diseases, Section of Haematology
Search for more papers by this authorMario Luppi
Department of Oncology, Haematology and Respiratory Diseases, Section of Haematology
Search for more papers by this authorAbstract
Clinical charts from 63 consecutive highly immunocompromised haematologic patients presenting with pulmonary nodular lesions on CT scan, classified as either probable or possible invasive fungal disease (IFD) according to the revised EORTC/MSG classification, were retrospectively studied. Histopathological analysis of lung tissues, available for 23 patients, demonstrated proven IFD in 17 cases (14 invasive aspergillosis and 3 invasive zygomycosis), diffuse alveolar damage in one and organising pneumonia (OP) in five cases. In the OP cases, three of which have been defined as probable IFD according to EORTC/MSG classification, extensive immunohistochemical, molecular and immunological analyses for fungi were negative. Our case descriptions extend the notion that OP may be encountered as a distinct histopathological entity in pulmonary nodular lesions in patients with leukaemia with probable/possible IFD.
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