Comparison of IgG avidity assays in the confirmation of the diagnosis of cytomegalovirus primary infection
Fernando de Ory Manchón, Servicio de Microbiología Diagnóstica, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda 28220, Madrid, Spain. e-mail: [email protected]
Abstract
Guisasola ME, Ramos B, Sanz JC, García-Bermejo I, de Ory Manchón F. Comparison of IgG avidity assays in the confirmation of the diagnosis of cytomegalovirus primary infection. APMIS 2010; 118: 991–3.
We have compared three ELISA techniques and one chemiluminescence immunoassay technique for determining cytomegalovirus (CMV) immunoglobulin G (IgG) avidity in serum samples from patients with recent and past CMV infections. Sensitivity varied from 84.6% to 100%; and specificity from 78.6% to 100%. IgG avidity assays appear to be adequate additional tools for characterizing CMV infections.
