Antithrombin, protein C and protein S levels in 127 consecutive young adults with ischemic stroke
Corresponding Author
C. Lucas
Departments of Neurology, University of Lille, France
C. Lucas, Clinique Neurologique, Hflpital Roger Salengro, F-59037 Lille Cedex (France)Search for more papers by this authorC. Caron
Departments of Haematology, University of Lille, France
Departments of Neurology, University of Lille, France
Search for more papers by this authorJ. Goudemand
Departments of Haematology, University of Lille, France
Departments of Neurology, University of Lille, France
Search for more papers by this authorCorresponding Author
C. Lucas
Departments of Neurology, University of Lille, France
C. Lucas, Clinique Neurologique, Hflpital Roger Salengro, F-59037 Lille Cedex (France)Search for more papers by this authorC. Caron
Departments of Haematology, University of Lille, France
Departments of Neurology, University of Lille, France
Search for more papers by this authorJ. Goudemand
Departments of Haematology, University of Lille, France
Departments of Neurology, University of Lille, France
Search for more papers by this authorAbstract
Objectives - The aim of our study was to evaluate the prevalence of antithrombin, protein C and protein S deficiencies in consecutive ischemic stroke patients under 45. Material and methods - We studied 127 consecutive patients with a mean age of 34.4 years admitted for an ischemic stroke, over a 2-year period, after exclusion of those with arterial dissection. Antithrombin, protein C and protein S levels were measured in all patients at the acute stage of the ischemic stroke and measurements were repeated in case of abnormality. Results - We found abnormal levels in 9 patients. Seven had an acquired cause of deficiency (pregnancy, oestrogen, acute inflammation). Two had no obvious acquired cause of deficiency but further controls were normal. Conclusions - Hereditary deficiencies of coagulation inhibitors are rare in ischemic stroke patients under 45 and their systematic detection seems to be of poor interest.
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