DeoT, a DeoR-type transcriptional regulator of multiple target genes
Maya Elgrably-Weiss,
Eliana Schlosser-Silverman,
Ilan Rosenshine,
Shoshy Altuvia,
Maya Elgrably-Weiss
* These authors contributed equally to this work.
Search for more papers by this authorEliana Schlosser-Silverman
* These authors contributed equally to this work.
Search for more papers by this authorIlan Rosenshine
Department of Molecular Genetics and Biotechnology, The Hebrew University-Hadassah Medical School, Jerusalem, Israel
Search for more papers by this authorShoshy Altuvia
Department of Molecular Genetics and Biotechnology, The Hebrew University-Hadassah Medical School, Jerusalem, Israel
Search for more papers by this authorMaya Elgrably-Weiss,
Eliana Schlosser-Silverman,
Ilan Rosenshine,
Shoshy Altuvia,
Maya Elgrably-Weiss
* These authors contributed equally to this work.
Search for more papers by this authorEliana Schlosser-Silverman
* These authors contributed equally to this work.
Search for more papers by this authorIlan Rosenshine
Department of Molecular Genetics and Biotechnology, The Hebrew University-Hadassah Medical School, Jerusalem, Israel
Search for more papers by this authorShoshy Altuvia
Department of Molecular Genetics and Biotechnology, The Hebrew University-Hadassah Medical School, Jerusalem, Israel
Search for more papers by this authorCorrespondence: Shoshy Altuvia, Department of Molecular Genetics and Biotechnology, The Hebrew University-Hadassah Medical School, 91120 Jerusalem, Israel. Tel.: +972 2 6757212; fax: +972 2 6757308; e-mail: [email protected]
Editor: Marco Soria
Abstract
In this study, we investigated the genetic organization and function of Escherichia coli yciT, a gene predicted by computational methods to belong to the DeoR-type family of transcriptional regulators. We show that transcription of yciT (here denoted deoT for deoR-Type) initiates from a promoter located upstream of a putative open reading frame (denoted deoL for deoT Leader). We also show that DeoT acts as a global regulator, repressing the expression of a number of genes involved in a variety of metabolic pathways including transport of maltose, fatty acid β-oxidation and peptide degradation.
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