Volume 151, Issue 1 pp. 89-94

Palmitoyl carnitine, a lysophospholipase-transacylase inhibitor, prevents Candida adherence in vitro

Akraporn Prakobphol,

Akraporn Prakobphol

Department of Stomatology, University of California San Francisco, San Francisco, CA 94143, USA

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Hakon Leffler,

Hakon Leffler

Department of Psychiatry, University of California San Francisco, San Francisco, CA 94143, USA

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Charles I. Hoover,

Charles I. Hoover

Department of Stomatology, University of California San Francisco, San Francisco, CA 94143, USA

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Susan J. Fisher,

Corresponding Author

Susan J. Fisher

Department of Stomatology, University of California San Francisco, San Francisco, CA 94143, USA

Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA 94143, USA

Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA 94143, USA

Department of Anatomy, University of California San Francisco, San Francisco, CA 94143, USA

Corresponding author. HSW 604, University of California San Francisco, San Francisco, CA 94143–0512, USA. Tel.: +1 (415) 476–5297; fax: +1 (415) 476–4204; e-mail: [email protected]Search for more papers by this author

Akraporn Prakobphol,

Akraporn Prakobphol

Department of Stomatology, University of California San Francisco, San Francisco, CA 94143, USA

Search for more papers by this author

Hakon Leffler,

Hakon Leffler

Department of Psychiatry, University of California San Francisco, San Francisco, CA 94143, USA

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Charles I. Hoover,

Charles I. Hoover

Department of Stomatology, University of California San Francisco, San Francisco, CA 94143, USA

Search for more papers by this author

Susan J. Fisher,

Corresponding Author

Susan J. Fisher

Department of Stomatology, University of California San Francisco, San Francisco, CA 94143, USA

Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA 94143, USA

Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA 94143, USA

Department of Anatomy, University of California San Francisco, San Francisco, CA 94143, USA

First published: 17 January 2006

https://doi.org/10.1111/j.1574-6968.1997.tb10399.x

Citations: 4

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Abstract

Candida adherence is poorly understood. The results of this study indicate that interactions of Candida with the lyso-forms of phospholipids may be one important attachment mechanism. C. tropicalis and C. albicans adhered to purified lysophospholipids immobilized on microtiter wells, as well as to a human laryngeal epidermoid carcinoma (HEp-2) cell line. Adherence to both lysophospholipids and HEp-2 cells was significantly reduced by palmitoyl carnitine, a lysophospholipase-transacylase inhibitor. Over time there was a positive correlation between Candida adherence and its transacylase activity. The data suggest that palmitoyl carnitine interferes with Candida adherence to lysophospholipids and the HEp-2 cell line by blocking the interaction between the Candida-associated transacylase enzyme receptor site and its lysophospholipid substrate ligand.

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Volume151, Issue1

June 1997

Pages 89-94

Palmitoyl carnitine, a lysophospholipase-transacylase inhibitor, prevents Candida adherence in vitro

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Palmitoyl carnitine, a lysophospholipase-transacylase inhibitor, prevents Candida adherence in vitro

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