Remote Ischemic Conditioning: Evolution of the Concept, Mechanisms, and Clinical Application
Pankaj Saxena M.Ch., D.N.B.,
Mark A.J. Newman D.S., F.R.A.C.S.,
Jaffar S. Shehatha F.R.C.S., F.R.A.C.S.,
Andrew N. Redington F.R.C.P., F.R.C.P.C.,
Igor E. Konstantinov M.D., Ph.D.,
Pankaj Saxena M.Ch., D.N.B.
Department of Cardiothoracic Surgery, Sir Charles Gairdner Hospital, University of Western Australia, Perth, Australia
Search for more papers by this authorMark A.J. Newman D.S., F.R.A.C.S.
Department of Cardiothoracic Surgery, Sir Charles Gairdner Hospital, University of Western Australia, Perth, Australia
Search for more papers by this authorJaffar S. Shehatha F.R.C.S., F.R.A.C.S.
Department of Cardiothoracic Surgery, Sir Charles Gairdner Hospital, University of Western Australia, Perth, Australia
Search for more papers by this authorAndrew N. Redington F.R.C.P., F.R.C.P.C.
Department of Cardiology, Hospital for Sick Children, University of Toronto, Toronto, Canada
Search for more papers by this authorIgor E. Konstantinov M.D., Ph.D.
Department of Cardiothoracic Surgery, Sir Charles Gairdner Hospital, University of Western Australia, Perth, Australia
Cardiac Surgery Unit, Royal Children's Hospital, Melbourne, Australia
Search for more papers by this authorPankaj Saxena M.Ch., D.N.B.,
Mark A.J. Newman D.S., F.R.A.C.S.,
Jaffar S. Shehatha F.R.C.S., F.R.A.C.S.,
Andrew N. Redington F.R.C.P., F.R.C.P.C.,
Igor E. Konstantinov M.D., Ph.D.,
Pankaj Saxena M.Ch., D.N.B.
Department of Cardiothoracic Surgery, Sir Charles Gairdner Hospital, University of Western Australia, Perth, Australia
Search for more papers by this authorMark A.J. Newman D.S., F.R.A.C.S.
Department of Cardiothoracic Surgery, Sir Charles Gairdner Hospital, University of Western Australia, Perth, Australia
Search for more papers by this authorJaffar S. Shehatha F.R.C.S., F.R.A.C.S.
Department of Cardiothoracic Surgery, Sir Charles Gairdner Hospital, University of Western Australia, Perth, Australia
Search for more papers by this authorAndrew N. Redington F.R.C.P., F.R.C.P.C.
Department of Cardiology, Hospital for Sick Children, University of Toronto, Toronto, Canada
Search for more papers by this authorIgor E. Konstantinov M.D., Ph.D.
Department of Cardiothoracic Surgery, Sir Charles Gairdner Hospital, University of Western Australia, Perth, Australia
Cardiac Surgery Unit, Royal Children's Hospital, Melbourne, Australia
Search for more papers by this authorAddress for correspondence: Igor E. Konstantinov, M.D., Ph.D., Cardiac Surgery Unit, Royal Children's Hospital, Flemington Road, Parkville, Victoria 3052, Melbourne, Australia. Fax: 61-3-9345-6386; e-mail: [email protected]
Abstract
Abstract Remote ischemic conditioning is a novel concept of protection against ischemia-reperfusion injury. Brief controlled episodes of intermittent ischemia of the arm or leg may confer a powerful systemic protection against prolonged ischemia in a distant organ. This conditioning phenomenon is clinically applicable and can be performed before—preconditioning, during—perconditioning, or after—postconditioning prolonged distant organ ischemia. The remote ischemic conditioning may have an immense impact on clinical practice in the near future. (J Card Surg 2010;25:127-134)
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