Address for reprints: Katsumi Matsumoto, M.D., Department of Medical Science and Cardiorenal Medicine Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan. Fax: +81-45-701-3738; e-mail: [email protected]

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Abstract

Background: We assessed left ventricular (LV) function and myocardial glucose metabolism by fluoro-18-deoxyglucose (¹⁸F-FDG) positron emission tomography (PET) in patients with tachycardia-induced cardiomyopathy (TC).

Methods: The subjects were 42 patients with heart disease, consisting of 7 patients with TC (61.4 ± 19.0 years, LVEF 34.1%± 10.6%) and 35 with ischemic heart disease (IHD) (63.1 ± 10.8 years, LVEF 49.9%± 13.5%). Five volunteers with normal ECG were the control group. All of the patients underwent ¹⁸F-FDG PET and echocardiography, and all of the patients with TC underwent ¹⁸F-FDG PET and echocardiography before and 6 months after antitachycardia therapy. Six patients underwent radiofrequency catheter ablation (RFCA) and 1 patient was medically treated with antitachycardia therapy. Myocardial glucose metabolism was assessed semiquantitatively by using the % dose uptake of 60 kg of BW (% dose uptake).

Results: Mean % dose uptake of the control group was 5.52 ± 0.54%. After antitachycardia therapy, LVEF significantly improved (34.1 ± 10.6% vs 54.3 ± 13.6%, P < 0.01), and % dose uptake also significantly improved (1.26 ± 0.55% vs 1.49 ± 0.62%, P < 0.05). Patients with IHD showed higher % dose uptake than those with TC before antitachycardia therapy (3.18 ± 1.36 vs 1.26 ± 0.55%, P < 0.01), controls showed higher value of % dose uptake than TC before antitachycardia therapy (5.52 ± 0.54% vs 1.26 ± 0.55%, P < 0.01).

Conclusion: Semiquantitative analysis of ¹⁸F-FDG PET showed that antitachycardia therapy improved myocardial glucose metabolism in patients with TC.

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Volume29, Issue2

February 2006

Pages 175-180

Evaluation of Myocardial Glucose Metabolism Before and After Recovery of Myocardial Function in Patients with Tachycardia-Induced Cardiomyopathy

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Evaluation of Myocardial Glucose Metabolism Before and After Recovery of Myocardial Function in Patients with Tachycardia-Induced Cardiomyopathy

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