Evidence of shared genetic risk factors for migraine and rolandic epilepsy

Tara Clarke

Department of Epidemiology, Mailman School of Public Health, Columbia University Medical Center, New York City, New York, U.S.A.

Search for more papers by this author

Zeynep Baskurt,

Zeynep Baskurt

Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada

Search for more papers by this author

Lisa J. Strug,

Lisa J. Strug

Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada

Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada

Search for more papers by this author

Deb K. Pal,

Deb K. Pal

Department of Epidemiology, Mailman School of Public Health, Columbia University Medical Center, New York City, New York, U.S.A.

Epidemiology Division, Department of Psychiatry, Columbia University Medical Center, New York City, New York, U.S.A.

Division of Statistical Genetics, Mailman School of Public Health, Columbia University Medical Center, New York City, New York, U.S.A.

Search for more papers by this author

Tara Clarke,

Tara Clarke

Department of Epidemiology, Mailman School of Public Health, Columbia University Medical Center, New York City, New York, U.S.A.

Search for more papers by this author

Zeynep Baskurt,

Zeynep Baskurt

Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada

Search for more papers by this author

Lisa J. Strug,

Lisa J. Strug

Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada

Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada

Search for more papers by this author

Deb K. Pal,

Deb K. Pal

Department of Epidemiology, Mailman School of Public Health, Columbia University Medical Center, New York City, New York, U.S.A.

Epidemiology Division, Department of Psychiatry, Columbia University Medical Center, New York City, New York, U.S.A.

Division of Statistical Genetics, Mailman School of Public Health, Columbia University Medical Center, New York City, New York, U.S.A.

Search for more papers by this author

First published: 23 October 2009

https://doi.org/10.1111/j.1528-1167.2009.02240.x

Citations: 51

Address correspondence to Dr. Deb K. Pal, Department of Clinical Neuroscience, Institute of Psychiatry, King’s College London, London SE5 8AF, U.K. E-mail: [email protected]

Share a link

Email
Wechat
Bluesky

Summary

Purpose: Evidence for a specific association between migraine and rolandic epilepsy (RE) has been conflicting. Children with migraine frequently have electroencephalographic (EEG) abnormalities, including rolandic discharges, and approximately 50% of siblings of patients with RE exhibit rolandic discharges. We assessed migraine risk in RE probands and their siblings.

Methods: We used cohort and reconstructed cohort designs to respectively assess the relative risk of migraine in 72 children with RE and their 88 siblings using International Classification of Headache Disorders (ICHD-2) criteria. Incidences were compared in 150 age and geographically matched nonepilepsy probands and their 188 siblings. We used a Cox proportional hazards model, using age as the time base, adjusting hazard ratios (HRs) for sex in the proband analysis, and for sex and proband migraine status in the sibling analysis.

Results: Prevalence of migraine in RE probands was 15% versus 7% in nonepilepsy probands, and in siblings of RE probands prevalence was 14% versus 4% in nonepilepsy siblings. The sex-adjusted HR of migraine for an RE proband was 2.46 [95% confidence interval (CI) 1.06–5.70]. The adjusted HR of having ≥1 sibling with migraine in an RE family was 3.35 (95% CI 1.20–9.33), whereas the HR of any one sibling of a RE proband was 2.86 (95% CI 1.10–7.43).

Discussion: Migraine is strongly comorbid in RE and independently clusters in their siblings. These results suggest shared susceptibility to migraine and RE that is not directly mediated by epileptic seizures. Susceptibility gene variants for RE may be tested as risk factors for migraine.

References

Headache Classification Subcommittee of the International Headache Society. (2004) The International Classification of Headache Disorders, 2nd edn. Cephalalgia 24 (suppl 1): 9–160.
Google Scholar
Andermann F, Andermann E. (1992) Migraine and epilepsy, with special reference to the benign epilepsies of childhood. Epilepsy Res Suppl 6: 207–214.
CAS PubMed Google Scholar
Andermann F, Zifkin B. (1998) The benign occipital epilepsies of childhood: an overview of the idiopathic syndromes and of the relationship to migraine. Epilepsia 39(suppl 4): S9–S23.
10.1111/j.1528-1157.1998.tb05129.x
PubMed Web of Science® Google Scholar
Bali B, Kugler SL, Pal DK. (2005) Genetic influence on Rolandic epilepsy. Ann Neurol 57: 464–465.
10.1002/ana.20399
PubMed Web of Science® Google Scholar
Bali B, Kull L, Strug L, Clarke T, Murphy PL, Akman C, Greenberg DA, Pal DK. (2007) Autosomal dominant inheritance of centrotemporal sharp waves in rolandic epilepsy families. Epilepsia 48: 2266–2272.
10.1111/j.1528-1167.2007.01221.x
CAS PubMed Web of Science® Google Scholar
Berg AT, Levy SR, Testa FM, Shinnar S. (1999) Classification of childhood epilepsy syndromes in newly diagnosed epilepsy: interrater agreement and reasons for disagreement. Epilepsia 40: 439–444.
10.1111/j.1528-1157.1999.tb00738.x
CAS PubMed Web of Science® Google Scholar
Bladin PF. (1987) The association of benign rolandic epilepsy with migraine. In F Andermann, E Lugharesi (Eds) Migraine and epilepsy. Butterworths, Boston, pp. 145–152.
Google Scholar
Boxerman JL, Hawash K, Bali B, Clarke T, Rogg J, Pal DK. (2007) Is Rolandic epilepsy associated with abnormal findings on cranial MRI? Epilepsy Res 75: 180–185.
10.1016/j.eplepsyres.2007.06.001
PubMed Web of Science® Google Scholar
Clarke T, Strug LJ, Murphy PL, Bali B, Carvalho J, Foster S, Tremont G, Gagnon BR, Dorta N, Pal DK. (2007) High risk of reading disability and speech sound disorder in rolandic epilepsy families: case-control study. Epilepsia 48: 2258–2265.
10.1111/j.1528-1167.2007.01276.x
CAS PubMed Web of Science® Google Scholar
Froelich WA, Carter CC, O’Leary JL, Rosenbaum HE. (1960) Headache in childhood. Electroencephalographic evaluation of 500 cases. Neurology 10: 639–642.
10.1212/WNL.10.7.639
CAS PubMed Web of Science® Google Scholar
Gervil M, Ulrich V, Kaprio J, Olesen J, Russell MB. (1999) The relative role of genetic and environmental factors in migraine without aura. Neurology 53: 995–999.
10.1212/WNL.53.5.995
CAS PubMed Web of Science® Google Scholar
Giroud M, Couillault G, Arnould S, Dauvergne M, Dumas R, Nivelon JL. (1989) Epilepsy with rolandic paroxysms and migraine, a non-fortuitous association. Results of a controlled study. Pediatrie 44: 659–664.
CAS PubMed Web of Science® Google Scholar
Hershey AD, Winner P, Kabbouche MA, Gladstein J, Yonker M, Lewis D, Pearlman E, Linder SL, Rothner AD, Powers SW. (2005) Use of the ICHD-II criteria in the diagnosis of pediatric migraine. Headache 45: 1288–1297.
10.1111/j.1526-4610.2005.00260.x
PubMed Web of Science® Google Scholar
Kavros PM, Clarke T, Strug LJ, Halperin JM, Dorta NJ, Pal DK. (2008) Attention impairment in rolandic epilepsy: systematic review. Epilepsia 49: 1570–1580.
10.1111/j.1528-1167.2008.01610.x
CAS PubMed Web of Science® Google Scholar
Kelly PJ. (2004) A review of software packages for analyzing correlated survival data. Am Stat [Alexandria] 58: 337–342.
10.1198/000313004X5419
Web of Science® Google Scholar
Kinast M, Lueders H, Rothner AD, Erenberg G. (1982) Benign focal epileptiform discharges in childhood migraine (BFEDC). Neurology 32: 1309–1311.
10.1212/WNL.32.11.1309
CAS PubMed Web of Science® Google Scholar
Lennox WG, Lennox MA. (1960) Epilepsy and related disorders. Little, Brown, Boston, pp. 438–463.
Google Scholar
Lima MM, Padula NA, Santos LC, Oliveira LD, Agapejev S, Padovani C. (2005) Critical analysis of the international classification of headache disorders diagnostic criteria (ICHD I-1988) and (ICHD II-2004), for migraine in children and adolescents. Cephalalgia 25: 1042–1047.
10.1111/j.1468-2982.2005.00954.x
CAS PubMed Web of Science® Google Scholar
Lipton RB. (1997) Diagnosis and epidemiology of pediatric migraine. Curr Opin Neurol 10: 231–236.
10.1097/00019052-199706000-00011
CAS PubMed Web of Science® Google Scholar
Ottman R, Lipton RB. (1994) Comorbidity of migraine and epilepsy. Neurology 44: 2105–2110.
10.1212/WNL.44.11.2105
CAS PubMed Web of Science® Google Scholar
Prensky AL, Sommer D. (1979) Diagnosis and treatment of migraine in children. Neurology 29: 506–510.
10.1212/WNL.29.4.506
CAS PubMed Web of Science® Google Scholar
R Development Core Team. (2008) R: a language and environment for statistical computing version 2.7.0 (2008-04-22). R Foundation for Statistical Computing, Vienna, Austria.
Google Scholar
Santucci M, Giovanardi Rossi P, Ambrosetto G, Sacquegna T, D’Alessandro R. (1985) Migraine and benign epilepsy with Rolandic spikes in childhood: a case-control study. Dev Med Child Neurol 27: 60–62.
10.1111/j.1469-8749.1985.tb04525.x
CAS PubMed Web of Science® Google Scholar
SAS II. (20022003) SAS software version 9.1.3 for windows. SAS Institute Inc., Cary, NC.
Google Scholar
Septien L, Pelletier JL, Brunotte F, Giroud M, Dumas R. (1991) Migraine in patients with history of centro-temporal epilepsy in childhood: a Hm-PAO SPECT study. Cephalalgia 11: 281–284.
10.1046/j.1468-2982.1991.1106281.x
CAS PubMed Web of Science® Google Scholar
Strug LJ, Clarke T, Chiang T, Chien M, Baskurt Z, Li W, Dorfman R, Bali B, Wirrell E, Kugler SL, Mandelbaum DE, Wolf SM, McGoldrick P, Hardison H, Novotny EJ, Ju J, Greenberg DA, Russo JJ, Pal DK. (2009) Centrotemporal sharp wave EEG trait in rolandic epilepsy maps to Elongator Protein Complex 4 (ELP4). Eur J Hum Genet January 28, 2009, doi 10.1038/ejhg.2008.267 [Epub ahead of print].
10.1038/ejhg.2008.267
PubMed Web of Science® Google Scholar
Wessman M, Terwindt GM, Kaunisto MA, Palotie A, Ophoff RA. (2007) Migraine: a complex genetic disorder. Lancet Neurol 6: 521–532.
10.1016/S1474-4422(07)70126-6
CAS PubMed Web of Science® Google Scholar
Wirrell EC, Hamiwka LD. (2006) Do children with benign rolandic epilepsy have a higher prevalence of migraine than those with other partial epilepsies or nonepilepsy controls? Epilepsia 47: 1674–1681.
10.1111/j.1528-1167.2006.00639.x
PubMed Web of Science® Google Scholar
Ziegler DK, Wong G Jr. (1967) Migraine in children: clinical and electroencephalographic study of families. The possible relation to epilepsy. Epilepsia 8: 171–187.
10.1111/j.1528-1157.1967.tb04434.x
CAS PubMed Google Scholar

Citing Literature

Volume50, Issue11

November 2009

Pages 2428-2433

Evidence of shared genetic risk factors for migraine and rolandic epilepsy

Summary

References

Citing Literature

References

Information

About Wiley Online Library

Help & Support

Opportunities

Connect with Wiley

Evidence of shared genetic risk factors for migraine and rolandic epilepsy

Summary

References

Citing Literature

References

Related

Information