Mauro García-Toro, MD, Servicio de Psiquiatría, Hospital Son Llatzer, C/ Ctra de Manacor, Km 4, 07198 Palma de Mallorca, Spain. Tel: 0034 871 202154; Fax: 0034 871 202354; E-mail: [email protected].Search for more papers by this author

Blanca Carretero MD,

Blanca Carretero MD

Hospital Son Llatzer;

Search for more papers by this author

Ma José Martín MD,

Ma José Martín MD

Hospital Son Llatzer;

IUNICS, Universitat Illes Balears, Palma de Mallorca, Spain

Search for more papers by this author

Antonio Juan MD,

Antonio Juan MD

Hospital Son Llatzer;

Search for more papers by this author

Ma Luz Pradana PSYD,

Ma Luz Pradana PSYD

Hospital Son Llatzer;

Search for more papers by this author

Beatriz Martín PSYD,

Beatriz Martín PSYD

Hospital Son Llatzer;

Search for more papers by this author

Maria Carral MD,

Maria Carral MD

Hospital Son Llatzer;

Search for more papers by this author

Teresa Jimeno MD,

Teresa Jimeno MD

Hospital Son Llatzer;

Search for more papers by this author

Antonio Pareja MD,

Antonio Pareja MD

Hospital Son Llatzer;

IUNICS, Universitat Illes Balears, Palma de Mallorca, Spain

Search for more papers by this author

Pedro Montoya PSYD,

Pedro Montoya PSYD

IUNICS, Universitat Illes Balears, Palma de Mallorca, Spain

Search for more papers by this author

Iratxe Aguirre MD,

Iratxe Aguirre MD

Hospital Son Dureta;

IUNICS, Universitat Illes Balears, Palma de Mallorca, Spain

Search for more papers by this author

Joan Salva MD,

Joan Salva MD

Hospital Son Dureta;

IUNICS, Universitat Illes Balears, Palma de Mallorca, Spain

Search for more papers by this author

Miguel Roca MD,

Miguel Roca MD

IUNICS, Universitat Illes Balears, Palma de Mallorca, Spain

Search for more papers by this author

Margalida Gili PSYD,

Margalida Gili PSYD

IUNICS, Universitat Illes Balears, Palma de Mallorca, Spain

Search for more papers by this author

Mauro Garcia-Toro MD,

Corresponding Author

Mauro Garcia-Toro MD

Hospital Son Llatzer;

IUNICS, Universitat Illes Balears, Palma de Mallorca, Spain

First published: 05 June 2009

https://doi.org/10.1111/j.1526-4637.2009.00625.x

Citations: 5

Share a link

Email
Wechat
Bluesky

ABSTRACT

Objective. To study the efficacy of low-frequency transcranial magnetic stimulation in patients with fibromyalgia and major depression.

Design. Twenty-eight patients were randomly assigned to receive 20 sessions of real or sham transcranial magnetic stimulation of the right dorsolateral prefrontal cortex. The main stimulation parameters were 15 trains at 110% of the motor threshold for 60 seconds at a frequency of 1 Hz. Blinded external evaluators administered the fibromyalgia scales (FibroFatigue, Likert pain) and the depression scales (Hamilton Depression Rating Scale, Clinical Global Impression) during the study.

Results. Both treatment groups (real and sham) improved their scores in some of the scales (FibroFatigue and Clinical Global Impression), although there were no differences between them. No improvements were observed in the Likert Pain Scale in either of the groups.

Conclusion. With the methodology used in this study, patients with fibromyalgia and major depression who received real magnetic stimulation did not present significant differences in symptoms with respect to those who received sham magnetic stimulation.

References

1 Gershon AA, Dannon PN, Grunhaus L. Transcranial magnetic stimulation in the treatment of depression. Am J Psychiatry 2003; 160: 835–45.
10.1176/appi.ajp.160.5.835
PubMed Web of Science® Google Scholar
2 Hoffman RE, Cavus I. Slow transcranial magnetic stimulation, long-term depotentiation, and brain hyperexcitability disorders. Am J Psychiatry 2002; 159: 1093–102.
10.1176/appi.ajp.159.7.1093
PubMed Web of Science® Google Scholar
3 Gross M, Nakamura L, Pascual-Leone A, Fregni F. Has repetitive transcranial magnetic stimulation (rTMS) treatment for depression improved? A systematic review and meta-analysis comparing the recent vs. the earlier rTMS studies. Acta Psychiatr Scand 2007; 116: 165–73.
10.1111/j.1600-0447.2007.01049.x
CAS PubMed Web of Science® Google Scholar
4 George MS, Nahas Z, Borckardt JJ, et al. Brain stimulation for the treatment of psychiatric disorders. Curr Opin Psychiatry 2007; 20: 250–4.
PubMed Web of Science® Google Scholar
5 Mountz JM, Bradley LA, Alarcón GS. Abnormal functional activity of the central nervous system in fibromyalgia syndrome. Am J Med Sci 1998; 315: 385–96.
10.1097/00000441-199806000-00007
CAS PubMed Web of Science® Google Scholar
6 Demyttenaere K, Bonnewyn A, Bruffaerts R, et al. Comorbid painful physical symptoms and anxiety: Prevalence, work loss and help-seeking. J Affect Disord 2008; 109: 264–72.
10.1016/j.jad.2007.12.231
PubMed Web of Science® Google Scholar
7 Avery DH, Holtzheimer PE 3rd, Fawaz W, et al. Transcranial magnetic stimulation reduces pain in patients with major depression: A sham-controlled study. J Nerv Ment Dis 2007; 195: 378–81.
10.1097/NMD.0b013e31802f58d1
PubMed Web of Science® Google Scholar
8 Rooks DS. Fibromyalgia treatment update. Curr Opin Rheumatol 2007; 19: 111–7.
PubMed Web of Science® Google Scholar
9 Montoya P, Sitges C, García-Herrera M, et al. Abnormal affective modulation of somatosensory brain processing among patients with fibromyalgia. Psychosom Med 2005; 67: 957–63.
10.1097/01.psy.0000188401.55394.18
PubMed Web of Science® Google Scholar
10 Bradley LA, McKendree-Smith NL, Alberts KR, et al. Use of neuroimaging to understand abnormal pain sensitivity in fibromyalgia. Curr Rheumatol Rep 2000; 2: 141–8.
10.1007/s11926-000-0054-2
CAS PubMed Google Scholar
11 Alexander JL, Dennerstein L, Woods NF, et al. Arthralgias, bodily aches and pains and somatic complaints in midlife women: Etiology, pathophysiology and differential diagnosis. Expert Rev Neurother 2007; 7: S15–26.
10.1586/14737175.7.11s.S15
PubMed Google Scholar
12 Fietta P, Fietta P, Manganelli P. Fibromyalgia and psychiatric disorders. Acta Biomed 2007; 78: 88–95.
PubMed Google Scholar
13 Fregni F, Gimenes R, Valle AC, et al. A randomized, sham-controlled, proof of principle study of treatment of pain in fibromyalgia. Arthritis Rheum 2006; 54: 3988–98.
10.1002/art.22195
CAS PubMed Web of Science® Google Scholar
14 Arnold LM. Duloxetine and other antidepressants in the treatment of patients with fibromyalgia. Pain Med 2007; 8: S63–74.
10.1111/j.1526-4637.2006.00178.x
PubMed Web of Science® Google Scholar
15 Been G, Ngo TT, Miller SM, Fitzgerald PB. The use of tDCS and CVS as methods of non-invasive brain stimulation. Brain Res Rev 2007; 56: 346–61.
10.1016/j.brainresrev.2007.08.001
PubMed Web of Science® Google Scholar
16 Thimineur M, De Ridder D. C2 area neurostimulation: A surgical treatment for fibromyalgia. Pain Med 2007; 8: 639–46.
10.1111/j.1526-4637.2007.00365.x
CAS PubMed Web of Science® Google Scholar
17 Sampson SM, Rome JD, Rummans TA. Slow-frequency rTMS reduces fibromyalgia pain. Pain Med 2006; 7: 115–8.
10.1111/j.1526-4637.2006.00106.x
PubMed Web of Science® Google Scholar
18 Ramos-Brieva JA, Cordero A. A new validation of the Hamilton Rating Scale for Depression. J Psychiatr Res 1988; 22: 21–8.
10.1016/0022-3956(88)90024-6
CAS PubMed Web of Science® Google Scholar
19 García-Campayo J, Pascual A, Alda M, et al. The Spanish version of the FibroFatigue Scale: Validation of a questionnaire for the observer's assessment of fibromyalgia and chronic fatigue syndrome. Gen Hosp Psychiatry 2006; 28: 154–60.
10.1016/j.genhosppsych.2005.12.001
PubMed Web of Science® Google Scholar
20 Fregni F, Freedman S, Pascual-Leone A. Recent advances in the treatment of chronic pain with non-invasive brain stimulation techniques. Lancet Neurol 2007; 6: 188–91.
10.1016/S1474-4422(07)70032-7
PubMed Web of Science® Google Scholar
21 Passard A, Attal N, Benadhira R, et al. Effects of unilateral repetitive transcranial magnetic stimulation of the motor cortex on chronic widespread pain in fibromyalgia. Brain 2007; 130: 2661–70.
10.1093/brain/awm189
CAS PubMed Web of Science® Google Scholar
22 Roizenblatt S, Fregni F, Gimenez R, et al. Site-specific effects of transcranial direct current stimulation on sleep and pain in fibromyalgia: A randomized, sham-controlled study. Pain Pract 2007; 7: 297–306.
10.1111/j.1533-2500.2007.00152.x
CAS PubMed Google Scholar
23 Lefaucheur JP, Drouot X, Menard-Lefacheur I, Nguyen JP. Neuropathic pain controlled for more than a year by monthly sessions of repetitive transcranial magnetic stimulation of the motor cortex. Neurophysiol Clin 2004; 34: 91–5.
10.1016/j.neucli.2004.02.001
PubMed Web of Science® Google Scholar
24 Kherdr EM, Kotb H, Kamel NF, et al. Lasting antalgic effects of daily sessions of repetitive transcranial magnetic stimulation of the in central and peripheral neuropathic pain. J Neurol Neurosurg Psychiatr 2005; 76: 833–8.
10.1136/jnnp.2004.055806
PubMed Web of Science® Google Scholar
25 Montoya P, Larbig W, Braun C, Preissl H, Birbaumer N. Influence of social support and emotional context on pain processing and magnetic brain responses in fibromyalgia. Arthritis Rheum 2004; 50: 4035–44.
10.1002/art.20660
CAS PubMed Web of Science® Google Scholar
26 Price DD, Staud R. Neurobiology of fibromyalgia syndrome. J Rheumatol 2005; 75: 22–8.
PubMed Google Scholar
27 Nemeroff CB. The neurobiology of depression. Sci Am 1998; 278: 42–9.
10.1038/scientificamerican0698-42
CAS PubMed Web of Science® Google Scholar

Citing Literature

Volume10, Issue4

May/June 2009

Pages 748-753

Low-Frequency Transcranial Magnetic Stimulation in Patients with Fibromyalgia and Major Depression

ABSTRACT

References

Citing Literature

References

Information

About Wiley Online Library

Help & Support

Opportunities

Connect with Wiley

Low-Frequency Transcranial Magnetic Stimulation in Patients with Fibromyalgia and Major Depression

ABSTRACT

References

Citing Literature

References

Related

Information