Volume 27, Issue 3 pp. 290-293

Febrile Ulceronecrotic Mucha-Habermann’s Disease with Pulmonary Involvement

Li-xin Zhang M.D.,

Li-xin Zhang M.D.

Department of Dermatology, Beijing Children’s Hospital, Capital Medical University, Beijing, China

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Yuan Liang M.D.,

Yuan Liang M.D.

Department of Dermatology, Beijing Children’s Hospital, Capital Medical University, Beijing, China

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Ying Liu M.D.,

Ying Liu M.D.

Department of Dermatology, Beijing Children’s Hospital, Capital Medical University, Beijing, China

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Lin Ma Ph.D.,

Lin Ma Ph.D.

Department of Dermatology, Beijing Children’s Hospital, Capital Medical University, Beijing, China

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Li-xin Zhang M.D.,

Li-xin Zhang M.D.

Department of Dermatology, Beijing Children’s Hospital, Capital Medical University, Beijing, China

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Yuan Liang M.D.,

Yuan Liang M.D.

Department of Dermatology, Beijing Children’s Hospital, Capital Medical University, Beijing, China

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Ying Liu M.D.,

Ying Liu M.D.

Department of Dermatology, Beijing Children’s Hospital, Capital Medical University, Beijing, China

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Lin Ma Ph.D.,

Lin Ma Ph.D.

Department of Dermatology, Beijing Children’s Hospital, Capital Medical University, Beijing, China

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First published: 25 May 2010

https://doi.org/10.1111/j.1525-1470.2010.01141.x

Citations: 18

Address correspondence to Lin Ma, Ph.D., Department of Dermatology, Beijing Children’s Hospital, Capital Medical University, NO.56, Nan Lishi Road, Xicheng district, Beijing 100045, People’s Republic of China, or e-mail: [email protected].

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Abstract

Abstract: We report a case of febrile ulceronecrotic Mucha-Habermann disease (FUMHD) in a 12-year-old boy. After 1 week of typical cutaneous appearance of pityriasis lichenoides et varioliformis acuta (PLEVA), he was given a percutaneous injection of measles virus vaccine, and then extensive polymorphous, papular, and ulcerohemorrhagic skin lesions developed along with intermittent high temperature, hepatic dysfunction, and hypoalbuminemia. Thoracic CT scan showed parenchymal nodular infiltration at the tip of vascular structures. Skin biopsy showed a combination of the classic features of PLEVA and an allergic vasculitis. We treated him with prednisolone and methotrexate (MTX) successfully. The evolution in our patient suggests that FUMHD may have been triggered by virus vaccination. We also emphasize that FUMHD in children may be successfully treated with a combination of systemic MTX and high-dose corticosteroids.

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Volume27, Issue3

May/June 2010

Pages 290-293

Febrile Ulceronecrotic Mucha-Habermann’s Disease with Pulmonary Involvement

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