MR-spectroscopic imaging during visual stimulation in subgroups of migraine with aura
PS Sándor,
U Dydak,
J Schoenen,
Ss Kollias,
K Hess, P Boesiger,
RM Agosti,
Corresponding Author
PS Sándor
Neurology Department, University Hospital and
Dr P. S. Sándor, Neurology Department, Frauenklinikstrasse 26, University Hospitals Zürich, CH-8091 Zürich, Switzerland. Tel. + 41 76 320 5952, fax + 41 1271 5952, e-mail [email protected]Search for more papers by this authorU Dydak
Institute for Biomedical Engineering, University and ETH, ETH Zentrum, Zürich, Switzerland,
Search for more papers by this authorJ Schoenen
Neurology Department, University Hospital, CHR Citadelle, Liège, Belgium, and
Search for more papers by this authorSs Kollias
Institute of Neuroradiology, University Hospital, Zürich, Switzerland
Search for more papers by this authorP Boesiger
Institute for Biomedical Engineering, University and ETH, ETH Zentrum, Zürich, Switzerland,
Search for more papers by this authorPS Sándor,
U Dydak,
J Schoenen,
Ss Kollias,
K Hess, P Boesiger,
RM Agosti,
Corresponding Author
PS Sándor
Neurology Department, University Hospital and
Dr P. S. Sándor, Neurology Department, Frauenklinikstrasse 26, University Hospitals Zürich, CH-8091 Zürich, Switzerland. Tel. + 41 76 320 5952, fax + 41 1271 5952, e-mail [email protected]Search for more papers by this authorU Dydak
Institute for Biomedical Engineering, University and ETH, ETH Zentrum, Zürich, Switzerland,
Search for more papers by this authorJ Schoenen
Neurology Department, University Hospital, CHR Citadelle, Liège, Belgium, and
Search for more papers by this authorSs Kollias
Institute of Neuroradiology, University Hospital, Zürich, Switzerland
Search for more papers by this authorP Boesiger
Institute for Biomedical Engineering, University and ETH, ETH Zentrum, Zürich, Switzerland,
Search for more papers by this authorAbstract
Migraine pathophysiology possibly involves deficient mitochondrial energy reserve and diminished cortical habituation. Using functional magnetic resonance spectroscopic imaging (fMRSI), we studied cortical lactate changes during prolonged visual stimulation to search for different pathophysiological mechanisms in clinically distinct subgroups of migraine with aura. Eleven healthy volunteers (HV) and 10 migraine patients were investigated interictally: five with visual aura (MA) and five with visual symptoms and at least one of the following: paraesthesia, paresis or dysphasia (MAplus). Using MRSI (Philips, 1.5 T) 1H-spectra were repeatedly obtained from a 25 mm-thick slice covering visual and non-visual cortex, with the first and fifth measurements in darkness and the second to fourth with 8-Hz checkerboard stimulation. In MAplus lactate increased only during stimulation, only in visual cortex; in MA resting lactate was high in visual cortex, without further increase during stimulation. This is compatible with an abnormal metabolic strain during stimulation in MAplus, possibly due to dishabituation, and a predominant mitochondrial dysfunction in MA.
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