Volume 18, Issue 2 pp. 359-361

H63D polymorphism in the hemochromatosis gene is associated with sporadic amyotrophic lateral sclerosis in China

X. He,

X. He

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province

These authors contributed equally to this work.

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X. Lu,

X. Lu

Department of Neurology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province

These authors contributed equally to this work.

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J. Hu,

J. Hu

Department of Neurology, Third Hospital of Hebei Medical University, Sijiazhuang, Hebei Province, China

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J. Xi,

J. Xi

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province

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D. Zhou,

D. Zhou

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province

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H. Shang,

H. Shang

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province

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L. Liu,

L. Liu

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province

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H. Zhou,

H. Zhou

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province

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B. Yan,

B. Yan

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province

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L. Yu,

L. Yu

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province

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F. Hu,

F. Hu

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province

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Z. Liu,

Z. Liu

Department of Neurology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province

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L. He,

L. He

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province

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X. Yao,

X. Yao

Department of Neurology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province

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Y. Xu,

Y. Xu

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province

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X. He,

X. He

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province

These authors contributed equally to this work.

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X. Lu,

X. Lu

Department of Neurology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province

These authors contributed equally to this work.

Search for more papers by this author

J. Hu,

J. Hu

Department of Neurology, Third Hospital of Hebei Medical University, Sijiazhuang, Hebei Province, China

Search for more papers by this author

J. Xi,

J. Xi

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province

Search for more papers by this author

D. Zhou,

D. Zhou

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province

Search for more papers by this author

H. Shang,

H. Shang

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province

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L. Liu,

L. Liu

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province

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H. Zhou,

H. Zhou

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province

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B. Yan,

B. Yan

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province

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L. Yu,

L. Yu

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province

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F. Hu,

F. Hu

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province

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Z. Liu,

Z. Liu

Department of Neurology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province

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L. He,

L. He

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province

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X. Yao,

X. Yao

Department of Neurology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province

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Y. Xu,

Y. Xu

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province

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First published: 17 January 2011

https://doi.org/10.1111/j.1468-1331.2010.03158.x

Citations: 25

Y. Xu, Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, 610041, China (tel.: +86 28 8542 2716; fax: +86 2885423550; e-mail: [email protected], [email protected] (L. He), [email protected] (X. Yao).

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Abstract

Background and purpose: The H63D polymorphism in the hemochromatosis (HFE) gene has been reported as a risk factor for amyotrophic lateral sclerosis (ALS) in Europe and America, but no data have been reported for Asia. Here, we investigated the possible association between H63D and sporadic ALS (sALS) in a Chinese Han population.

Methods: A total of 195 individuals with sALS from three centers in China and 405 unrelated healthy controls were recruited. All subjects were genotyped by restriction fragment length polymorphism (RFLP) analysis.

Results: Sporadic ALS was significantly related to the H63D polymorphism in heterozygous carriers (odds ratio 3.10, 95%CI: 1.49–6.47, P = 0.002).

Conclusions: The HFE H63D polymorphism may contribute to the development of sALS in Chinese.

References

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Volume18, Issue2

February 2011

Pages 359-361

H63D polymorphism in the hemochromatosis gene is associated with sporadic amyotrophic lateral sclerosis in China

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H63D polymorphism in the hemochromatosis gene is associated with sporadic amyotrophic lateral sclerosis in China

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