Thrombotic thrombocytopenic purpura in advanced prostate cancer: Case report and published work review
All Authors contributed to the management of the patient during hospitalization. V. Caramello and A. Dovio also reviewed the published work on the subject and wrote the manuscript.
Abstract
Abstract: Thrombotic thrombocytopenic purpura (TTP) is a generalized disorder of the microcirculation characterized by microangiopathic hemolytic anemia (MHA), thrombocytopenic purpura and systemic microvascular thrombi. TTP has been previously described in two patients with prostate cancer (PC). We report a third case of TTP in a 61-year-old man with hormone-refractory bone metastatic PC. The syndrome presented with confusion, anuric acute renal failure, thrombocytopenia and MHA. A satisfactory recovery was achieved after plasma exchange (PE). TTP should be included in the coagulation disorders occurring in PC patients. Early treatment with plasma exchange is recommended in these particular cases.
