Infantile acute promyelocytic leukemia without an RARα rearrangement
Tsukasa Hori
Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo
Search for more papers by this authorCorresponding Author
Nobuhiro Suzuki
Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo
Nobuhiro Suzuki, MD, PhD, Department of Pediatrics, Sapporo Medical University School of Medicine, South-1, West-16, Chuo-ku, Sapporo 060-8543, Japan. Email: [email protected]Search for more papers by this authorNaoki Hatakeyama
Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo
Search for more papers by this authorMasaki Yamamoto
Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo
Search for more papers by this authorNatsuko Inazawa
Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo
Search for more papers by this authorHayato Miyachi
Department of Laboratory Medicine, Tokai University School of Medicine, Isehara
Search for more papers by this authorTomohiko Taki
Department of Molecular Diagnostics and Therapeutics, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan
Search for more papers by this authorHiroyuki Tsutsumi
Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo
Search for more papers by this authorTsukasa Hori
Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo
Search for more papers by this authorCorresponding Author
Nobuhiro Suzuki
Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo
Nobuhiro Suzuki, MD, PhD, Department of Pediatrics, Sapporo Medical University School of Medicine, South-1, West-16, Chuo-ku, Sapporo 060-8543, Japan. Email: [email protected]Search for more papers by this authorNaoki Hatakeyama
Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo
Search for more papers by this authorMasaki Yamamoto
Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo
Search for more papers by this authorNatsuko Inazawa
Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo
Search for more papers by this authorHayato Miyachi
Department of Laboratory Medicine, Tokai University School of Medicine, Isehara
Search for more papers by this authorTomohiko Taki
Department of Molecular Diagnostics and Therapeutics, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan
Search for more papers by this authorHiroyuki Tsutsumi
Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo
Search for more papers by this author
References
- 1 Gregory J Jr, Feusner J. Acute promyelocytic leukemia in children. Best Pract. Res. Clin. Haematol. 2003; 16: 483–94.
- 2 Grimwade D, Biondi A, Mozziconacci MJ et al. Characterization of acute promyelocytic leukemia cases lacking the classic t(15;17): Results of the European Working Party. Blood 2000; 96: 1297–308.
- 3 Sainty D, Liso V, Cantù-Rajnoldi A et al. A new morphologic classification system for acute promyelocytic leukemia distinguishes cases with underlying PLZF/RARA gene rearrangements. Blood 2000; 96: 1287–96.
- 4 Tomonaga M, Yoshida Y, Tagawa M et al. Cytochemistry of acute promyelocytic leukemia (M3): Leukemic promyelocytes exhibit heterogeneous patterns in cellular differentiation. Blood 1985; 66: 350–7.
- 5 Guglielmi C, Martelli MP, Diverio D et al. Immunophenotype of adult and childhood acute promyelocytic leukemia: Correlation with morphology, type of PML gene breakpoint and clinical outcome: A cooperative Italian study on 196 cases. Br. J. Haematol. 1998; 102: 1035–41.
- 6 Grimwade D, Lo Coco F. Acute promyelocytic leukemia: A model for the role of molecular diagnosis and residual disease monitoring in directing treatment approach in acute myeloid leukemia. Leukemia 2002; 16: 1959–73.
- 7 Catalano A, Dawson MA, Somana K et al. The PRKAR1A gene is fused to RARA in a new variant acute promyelocytic leukemia. Blood 2007; 110: 4073–6.
- 8 Redner RL, Corey SJ, Rush EA. Differentiation of t(5;17) variant acute promyelocytic leukemic blasts by all-trans retinoic acid. Leukemia 1997; 11: 1014–16.
- 9 Wells RA, Catzavelos C, Kamel-Reid S. Fusion of retinoic acid receptor alpha to NuMA, the nuclear mitotic apparatus protein, by a variant translocation in acute promyelocytic leukaemia. Nat. Genet. 1997; 17: 109–13.
- 10 Licht JD, Chomienne C, Goy A et al. Clinical and molecular characterization of a rare syndrome of acute promyelocytic leukemia associated with translocation (11;17). Blood 1995; 85: 1083–94.
- 11 Arnould C, Philippe C, Bourdon V, Gr goire MJ, Berger R, Jonveaux P. The signal transducer and activator of transcription STAT5b gene is a new partner of retinoic acid receptor alpha in acute promyelocytic-like leukaemia. Hum. Mol. Genet. 1999; 8: 1741–9.
- 12 Song X, Gong S, Chen J, Gao L, Yang J, Wang J. ATRA is effective to an acute promyelocytic leukemia patient without RARA gene rearrangement. Leuk. Res. 2010; 34: e190–e193.
- 13 Wang HP, Xu H, Chen ZM, Tong XM, Qian WB, Jin J. t(X;17) as the sole karyotypic anomaly in a case of M3r subtype of acute promyelocytic leukemia without RARalpha rearrangement. Leuk. Res. 2010; 34: e55–e57.
Citing Literature
