Polyomavirus nephropathy in renal allograft: Prevalence and correlation of histology with graft failure
MEI-CHIN WEN
Department of Pathology, and
College of Medicine and Nursing, HungKuang University,
Search for more papers by this authorJONG-DA LIAN
Division of Nephrology, Department of Internal Medicine, Chung Shan Medical University Hospital,
School of Medicine, Chung Shan Medical University
Search for more papers by this authorHORNG-RANG CHANG
Division of Nephrology, Department of Internal Medicine, Chung Shan Medical University Hospital,
School of Medicine, Chung Shan Medical University
Search for more papers by this authorKUO-HSIUNG SHU
School of Medicine, Chung Shan Medical University
Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital,
Search for more papers by this authorMING-JU WU
School of Medicine, Chung Shan Medical University
Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital,
Search for more papers by this authorCHENG-HSU CHEN
Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital,
Search for more papers by this authorYEE-JEE JAN
Department of Pathology, and
College of Medicine and Nursing, HungKuang University,
Search for more papers by this authorJOHN WANG
Department of Pathology, and
Institute of Medicine & Molecular Toxicology, Chung Shan Medical University, Taichung and
Search for more papers by this authorCorresponding Author
DECHING CHANG
Institute of Molecular Biology, National Chung Cheng University, Chia-Yi, Taiwan
Prof Deching Chang, Institute of Molecular Biology, National Chung Cheng University, 168 University Rd., Min-Hsiung, Chia-Yi 62102, Taiwan. Email: [email protected]Search for more papers by this authorMEI-CHIN WEN
Department of Pathology, and
College of Medicine and Nursing, HungKuang University,
Search for more papers by this authorJONG-DA LIAN
Division of Nephrology, Department of Internal Medicine, Chung Shan Medical University Hospital,
School of Medicine, Chung Shan Medical University
Search for more papers by this authorHORNG-RANG CHANG
Division of Nephrology, Department of Internal Medicine, Chung Shan Medical University Hospital,
School of Medicine, Chung Shan Medical University
Search for more papers by this authorKUO-HSIUNG SHU
School of Medicine, Chung Shan Medical University
Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital,
Search for more papers by this authorMING-JU WU
School of Medicine, Chung Shan Medical University
Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital,
Search for more papers by this authorCHENG-HSU CHEN
Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital,
Search for more papers by this authorYEE-JEE JAN
Department of Pathology, and
College of Medicine and Nursing, HungKuang University,
Search for more papers by this authorJOHN WANG
Department of Pathology, and
Institute of Medicine & Molecular Toxicology, Chung Shan Medical University, Taichung and
Search for more papers by this authorCorresponding Author
DECHING CHANG
Institute of Molecular Biology, National Chung Cheng University, Chia-Yi, Taiwan
Prof Deching Chang, Institute of Molecular Biology, National Chung Cheng University, 168 University Rd., Min-Hsiung, Chia-Yi 62102, Taiwan. Email: [email protected]Search for more papers by this authorSUMMARY:
Background: While polyomavirus nephropathy (PVN) is recognized as an emerging cause of graft loss in renal transplants, the prevalence rate of PVN in renal grafts is unclear in Taiwan.
Methods: Biopsies (n = 412) from 323 Taiwanese renal transplant patients were retrospectively analysed. PVN was diagnosed by the characteristic viropathic change in epithelial cells under light microscopic examination and a positive immunohistochemistry staining of anti-SV40 large T antigen. The viral cytopathic changes, interstitial inflammation, fibrosis and tubular atrophy were semiquantitatively assessed, based on the Banff 1997 classification and scoring for renal allograft.
Results: Seventeen cases were identified with evidence of PVN; the prevalence rate is 5.26%. Compared with non-PVN patients, they were more likely to have had previous rejection episodes, higher graft loss and shorter graft survival.
Conclusion: This retrospective study showed that we have similar findings to other reports with at least 5% prevalence of PVN and that patients diagnosed early do better, while those diagnosed with severe inflammation or damage do worse or are likely to lose their grafts.
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