Volume 88, Issue 1 pp. 10-16

Epidemiology of blood donors in Japan, positive for hepatitis B virus and hepatitis C virus by nucleic acid amplification testing

H. Murokawa,

H. Murokawa

Japanese Red Cross Headquarters, Blood Services Department, Tokyo, Japan

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A. Yoshikawa,

Corresponding Author

A. Yoshikawa

JRC Saitama Blood Center, Hidaka, Saitama, Japan

Correspondence: Akira Yoshikawa, Japanese Red Cross Saitama Blood Center, 1370–12, Takahagi, Hidaka-shi, Saitama-kenn, 350–1213, Japan E-mail: [email protected]Search for more papers by this author

H. Ohnuma,

H. Ohnuma

JRC Saitama Blood Center, Hidaka, Saitama, Japan

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A. Iwata,

A. Iwata

JRC Saitama Blood Center, Hidaka, Saitama, Japan

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N. Katoh,

N. Katoh

JRC Saitama Blood Center, Hidaka, Saitama, Japan

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M. Miyamoto,

M. Miyamoto

JRC Central Blood Center, Ota-ku, Tokyo, Japan

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H. Mine,

H. Mine

JRC Center for NAT and Quarantine, Fukuchiyama, Kyoto, Japan

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H. Emura,

H. Emura

JRC Plasma Fractionation Center, Hokkaido, Japan

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K. Tadokoro,

K. Tadokoro

Japanese Red Cross Headquarters, Blood Services Department, Tokyo, Japan

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the Japanese Red Cross NAT Screening Research Group,

the Japanese Red Cross NAT Screening Research Group

Japanese Red Cross Headquarters, Blood Services Department, Tokyo, Japan

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H. Murokawa,

H. Murokawa

Japanese Red Cross Headquarters, Blood Services Department, Tokyo, Japan

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A. Yoshikawa,

Corresponding Author

A. Yoshikawa

JRC Saitama Blood Center, Hidaka, Saitama, Japan

H. Ohnuma,

H. Ohnuma

JRC Saitama Blood Center, Hidaka, Saitama, Japan

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A. Iwata,

A. Iwata

JRC Saitama Blood Center, Hidaka, Saitama, Japan

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N. Katoh,

N. Katoh

JRC Saitama Blood Center, Hidaka, Saitama, Japan

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M. Miyamoto,

M. Miyamoto

JRC Central Blood Center, Ota-ku, Tokyo, Japan

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H. Mine,

H. Mine

JRC Center for NAT and Quarantine, Fukuchiyama, Kyoto, Japan

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H. Emura,

H. Emura

JRC Plasma Fractionation Center, Hokkaido, Japan

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K. Tadokoro,

K. Tadokoro

Japanese Red Cross Headquarters, Blood Services Department, Tokyo, Japan

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the Japanese Red Cross NAT Screening Research Group,

the Japanese Red Cross NAT Screening Research Group

Japanese Red Cross Headquarters, Blood Services Department, Tokyo, Japan

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First published: 21 January 2005

https://doi.org/10.1111/j.1423-0410.2005.00581.x

Citations: 20

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Abstract

Background and Objectives The Japanese Red Cross screens seronegative blood donors by nucleic acid amplification testing (NAT) for hepatitis B, hepatitis C and human immunodeficiency virus-1 markers. NAT-positive donors thus identified seemed to have a different infectious background from serologically positive donors. The purpose of our study was to characterize this background in the hepatitis B virus (HBV) and hepatitis C virus (HCV) NAT-positive donors.

Materials and Methods Some 328 HBV DNA-positive and 44 HCV RNA-positive donors were detected by NAT testing of seronegative blood donors. These were characterized regarding age, gender and genotype of HBV and HCV.

Results Those who were HBV NAT-positive were mainly young, in particular teenage girls. In Japan, genotypes C and B have previously been dominant, but recently genotype A has increased, and genotype H was recently detected. In HBV NAT-positive donors, the rate of genotype A was high (12·2%) compared with patients in hospital (1·7–2%). Donors who were HCV NAT-positive were also young, but mostly men in their twenties. The ratio of genotype 1b to 2a or 1b to 2b in HCV NAT-positive donors differed from that of hospitalized patients in Japan. We did not find genotype 1a, which is dominant in the USA.

Conclusions The high-risk donors detected by NAT were mainly young, with a different distribution of genotypes from that of hospitalized patients, regarding both HBV and HCV. The rare HBV genotype H has been found for the first time in Japan. The findings reflect the present spread of hepatitis viruses B and C.

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Volume88, Issue1

January 2005

Pages 10-16

Epidemiology of blood donors in Japan, positive for hepatitis B virus and hepatitis C virus by nucleic acid amplification testing

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Epidemiology of blood donors in Japan, positive for hepatitis B virus and hepatitis C virus by nucleic acid amplification testing

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