Clinical improvement and normalized Th1 cytokine profile in early and long-term interferon-α treatment in a suspected case of hyper-IgE syndrome
Rosa Bacchetta, San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Via Olgettina 58, I-20132 Milano, ItalyTel.: +39 02 2643 4703Fax: +39 02 2643 4668E-mail: [email protected]
Ulrike Benninghoff and Federica Cattaneo have equally contributed to this work.
Abstract
We are reporting on a 7-months-old boy with suspected hyper-IgE syndrome, presenting with a therapy resistant severe eczema and an overall reduction of in vitro cytokine production. Interferon-α (IFN-α) treatment resulted in a marked and stable clinical improvement and normalization of in vitro T-cell cytokine production, indicating a valid therapeutic potential of IFN-α as immunomodulating drug.
