Corresponding author: Eileen J. Burker, PhD, CRC, Division of Rehabilitation Counseling and Psychology, Departments of Allied Health Sciences and Psychiatry, CB #7205, 2087 Bondurant Hall, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7205, USA.
Tel.: +919 966 9125 ; fax: +919 966 9007; e-mail: [email protected]

The project described was supported, in part, by Award Number KL2RR025746 from the National Center for Research Resources. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Center for Research Resources or the National Institutes of Health.Joe Galanko is supported by NIH Grants DK 034987 and DK 056350.

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Abstract

Evon DM, Burker EJ, Galanko JA, Dedert E, Egan TM. Depressive symptoms and mortality in lung transplant.
Clin Transplant 2010 DOI: 10.1111/j.1399-0012.2010.01236.x. © 2010 John Wiley & Sons A/S.

Abstract: Objective: To determine whether depressive symptoms predicted survival before and after lung transplantation. We hypothesized that depressive symptoms might predict survival of wait-listed patients, but would not predict survival post-transplant.

Methods: This was a prospective, longitudinal study. Participants completed the Beck Depression Inventory pre-transplant. Pre-transplant survival analyses were conducted (n = 124) based on time from list date, to death, transplant, or censoring, if still alive. Post-transplant survival analyses were conducted (n = 76) based on time from transplant, to death or censoring. Cox proportional hazards regression analyses were utilized.

Results: In the unadjusted model, depressive symptoms predicted mortality for candidates awaiting lung transplant (p = 0.02); however, once models were adjusted for demographics and pulmonary status, the relationship between depressive symptoms and mortality rates was attenuated (p > 0.05). Depressive symptoms did not predict survival after lung transplant (p > 0.05).

Conclusions: Pre-transplant depressive symptoms were associated with mortality among lung transplant candidates in an unadjusted model and a model fit with demographics and forced expiratory volume in one second. Depressive symptoms do not exert an independent effect when forced expiratory vital capacity is added. Depressive symptoms do not predict mortality after transplant. Future studies need to determine whether pre-transplant psychosocial characteristics confer a greater risk for poorer transplant outcomes.

References

1 Egan T, Detterbach FC, Mill MR et al. Lung transplantation for cystic fibrosis: effective and durable therapy in a high-risk group. Ann Thorac Surg 1998: 6: 337.
10.1016/S0003-4975(98)00496-2
Web of Science® Google Scholar
2 Handelsman H. Single and double lung transplantation. AHCPR Pub. No. 92-0028. Rockville, MD: Agency for Health Care Research and Quality, 1991.
Google Scholar
3 American Society for Transplant Physicians (ASTP)/American Thoracic Society (ATS)/European Respiratory Society (ERS)/International Society for Heart and Lung Transplantation (ISHLT). Joint statement: international guidelines for the selection of lung transplant candidates. Am J Respir Crit Care Med 1998: 158: 335.
10.1164/ajrccm.158.1.15812
PubMed Google Scholar
4 Organ Procurement and Transplantation Network/Scientific Registry of Transplant Recipients. OPTN/SRTR 2006 Annual Report, Vol. 2007, 2006.
Google Scholar
5 Geertsma A, Ten Vergert EM, Bonsel GJ, De Boer WJ, Van Der Bij W. Does lung transplantation prolong life? A comparison of survival with and without transplantation. J Heart Lung Transplant 1998: 17: 511.
CAS PubMed Web of Science® Google Scholar
6 Hosenpud J, Novick R, Bennett L, Keck B, Fiol B, Daily O. The registry of the International Society for Heart and Lung Transplantation: thirteenth official report. J Heart Lung Transplant 1996: 15: 655.
CAS PubMed Web of Science® Google Scholar
7 Orens JB, Estenne M, Arcasoy S et al. International guidelines for the selection of lung transplant candidates: 2006 update—a consensus report from the Pulmonary Scientific Council of the International Society of Heart and Lung Transplantation. J Heart Lung Transplant 2006: 25: 745.
10.1016/j.healun.2006.03.011
PubMed Web of Science® Google Scholar
8 Olbrisch ME, Levenson JL. Psychosocial assessment of organ transplant candidates: current status of methodological and philosophical issues. Psychosomatics 1995: 36: 236.
10.1016/S0033-3182(95)71662-0
CAS PubMed Web of Science® Google Scholar
9 Rodrigue JR, Kanasky WF, Marhefka SL, Perri MG, Baz M. A psychometric normative database for pre-lung transplantation evaluations. J Clin Psychol Med Settings 2001: 8: 229.
10.1023/A:1011908511353
Web of Science® Google Scholar
10 Vermeulen KM, Ten Vergert EM, Verschuuren EA, Erasmus ME, Van Der Bij W. Pre-transplant quality of life does not predict survival after lung transplantation. J Heart Lung Transplant 2008: 27: 623.
10.1016/j.healun.2008.03.011
PubMed Web of Science® Google Scholar
11 Squier HC, Ries AL, Kaplan RM, Prewitt LM, Kriett JM, Jamieson SW. Quality of well-being predicts survival in lung transplantation candidates. Am J Respir Crit Care Med 1995: 152: 2032.
10.1164/ajrccm.152.6.8520772
PubMed Web of Science® Google Scholar
12 Egan T, McCullough K, Murray S et al. Risk factors for death after lung transplant in the U.S. J Heart Lung Transplant 2003: 22: S146.
10.1016/S1053-2498(02)00920-8
Google Scholar
13 Egan T, McCullough K, Murray S et al. Predictors of death on the UNOS lung transplant waiting list. J Heart Lung Transplant 2003: 22: S147.
10.1016/S1053-2498(02)00921-X
PubMed Google Scholar
14 McCullough KP, Bustami S, Murray S, Egan T, Merion RM. Time-dependent mortality risk of lung transplantation compared with remaining on the waitlist. J Heart Lung Transplant 2003: 22: S146.
10.1016/S1053-2498(02)00919-1
Google Scholar
15 Cohen L, Littlefield C, Kelly P, Maurer J, Abbey S. Predictors of quality of life and adjustment after lung transplantation. Chest 1998: 113: 633.
10.1378/chest.113.3.633
CAS PubMed Web of Science® Google Scholar
16 Woodman CL, Geist LJ, Vance S, Laxson C, Jones K, Kline JN. Psychiatric disorders and survival after lung transplantation. Psychosomatics 1999: 40: 293.
10.1016/S0033-3182(99)71221-1
CAS PubMed Web of Science® Google Scholar
17 Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuring depressive symptoms. Arch Gen Psychiatry 1961: 4: 561.
10.1001/archpsyc.1961.01710120031004
CAS PubMed Web of Science® Google Scholar
18 Beck AT, Steer RA, Garbin MG. Psychometric properties of the Beck Depression Inventory: twenty-five years later. Clin Psychol Rev 1988: 8: 77.
10.1016/0272-7358(88)90050-5
Web of Science® Google Scholar
19 Beck AT, Steer RA. The Revised Beck Depression Inventory. San Antonio: Psychological Corporation, 1987.
Google Scholar
20 Bumberry W, Oliver JM, McClure JN. Validation of the Beck Depressive Symptoms Inventory in a university population using psychiatric estimate as the criterion. J Consult Clin Psychol 1987: 46: 150.
10.1037/0022-006X.46.1.150
Google Scholar
21 Girard F, Chouinard P, Boudreault D et al. Prevalence and impact of pain on the quality of life of lung transplant recipients. Chest 2006: 130: 1535.
10.1378/chest.130.5.1535
PubMed Web of Science® Google Scholar
22 Prager LM, Wain JC, Roberts DH, Ginns LC. Medical and psychologic outcome of living lobar lung transplant donors. J Heart Lung Transplant 2006: 25: 1206.
10.1016/j.healun.2006.06.014
PubMed Web of Science® Google Scholar
23 Cox DR. Regression models and life tables (with discussion). J R Stat Soc 1972: 74: 187.
Google Scholar
24 Cox DR, Oakes D. Analysis of Survival Data. London: Chapman & Hall, 1984.
Google Scholar
25 Lin D, Wei L, Ying Z. Checking with Cox Model with cumulative sums of martingale-based residuals. Biometrika 1993: 80: 557.
10.1093/biomet/80.3.557
Web of Science® Google Scholar
26 Burker EJ, Carels RA, Thompson LF, Rodgers L, Egan T. Quality of life in patients awaiting lung transplant: cystic fibrosis versus other end-stage lung diseases. Pediatr Pulmonol 2000: 30: 453.
10.1002/1099-0496(200012)30:6<453::AID-PPUL3>3.0.CO;2-8
CAS PubMed Web of Science® Google Scholar
27 Parekh PI, Blumenthal JA, Babyak MA et al. Psychiatric disorder and quality of life in patients awaiting lung transplantation. Chest 2003: 124: 1682.
10.1378/chest.124.5.1682
PubMed Web of Science® Google Scholar
28 Burker EJ, Evon DM, Sedway JA, Egan T. Appraisal and coping as predictors of psychological distress and self-reported physical disability before lung transplantation. Prog Transplant 2004: 14: 1.
Google Scholar
29 Burker EJ, Evon DM, Sedway JA, Egan T. Religious coping, psychological distress, and disability among patients with end-stage pulmonary disease. J Clin Psychol Med Settings 2004: 11: 179.
10.1023/B:JOCS.0000037612.31730.56
Web of Science® Google Scholar
30 Putzke JD, Boll TJ, Williams MA, Benza RC, Kirklin JK, McGriffin DC. Self-report measures among transplant candidates: the impact of evaluative situations. Assessment 2001: 8: 19.
10.1177/107319110100800103
CAS PubMed Web of Science® Google Scholar
31 Carnike CLM, McCracken LM, Aikens JE. Social desirability, perceived stress, and PACT ratings in lung transplant candidates: a preliminary investigation. J Clin Psychol Med Settings 1996: 3: 57.
10.1007/BF01989289
PubMed Web of Science® Google Scholar
32 Harper R, Chacko R, Kotik-Harper D, Young J, Gotto J. Self-report evaluation of health behavior, stress vulnerability, and medical outcome of heart transplant recipients. Psychosom Med 1998: 60: 563.
10.1097/00006842-199809000-00009
CAS PubMed Web of Science® Google Scholar
33 Chacko RC, Harper RG, Gotto J, Young J. Psychiatric interview and psychometric predictors of cardiac transplant survival. Am J Psychiatry 1996: 153: 1607.
10.1176/ajp.153.12.1607
CAS PubMed Web of Science® Google Scholar
34 Molassiotis A, Van Der Akker OBA, Milligan DW, Goldman JM. Symptom distress, coping style and biological variables as predictors of survival after bone marrow transplantation. J Psychosom Res 1997: 42: 275.
10.1016/S0022-3999(96)00298-X
CAS PubMed Web of Science® Google Scholar
35 Burker EJ, Evon DM, Galanko J, Egan T. Health locus of control predicts survival after lung transplant. J Health Psychol 2005: 10: 695.
10.1177/1359105305055326
PubMed Web of Science® Google Scholar

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Volume24, Issue5

September/October 2010

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