Correlation of serum basic fetoprotein with acute rejection in kidney transplantation
Corresponding Author
T. Seguchi M.D.
Department of Urology, Osaka University Hospital, 1-1-50 Fukushima, Fukushima-ku, Osaka, 553 Japan
Toshinobu Seguchi, Etsuji Nakano, Hiroshi Kameoka. Shirou Takahara. Mikio Namiki, Michio Ishibashi and Akihiko Okuyama, Department of Urology, Osaka University Hospital, Osaka, JapanSearch for more papers by this authorCorresponding Author
E. Nakano
Department of Urology, Osaka University Hospital, 1-1-50 Fukushima, Fukushima-ku, Osaka, 553 Japan
Toshinobu Seguchi, Etsuji Nakano, Hiroshi Kameoka. Shirou Takahara. Mikio Namiki, Michio Ishibashi and Akihiko Okuyama, Department of Urology, Osaka University Hospital, Osaka, JapanSearch for more papers by this authorCorresponding Author
H. Kameoka
Department of Urology, Osaka University Hospital, 1-1-50 Fukushima, Fukushima-ku, Osaka, 553 Japan
Toshinobu Seguchi, Etsuji Nakano, Hiroshi Kameoka. Shirou Takahara. Mikio Namiki, Michio Ishibashi and Akihiko Okuyama, Department of Urology, Osaka University Hospital, Osaka, JapanSearch for more papers by this authorCorresponding Author
S. Takahara
Department of Urology, Osaka University Hospital, 1-1-50 Fukushima, Fukushima-ku, Osaka, 553 Japan
Toshinobu Seguchi, Etsuji Nakano, Hiroshi Kameoka. Shirou Takahara. Mikio Namiki, Michio Ishibashi and Akihiko Okuyama, Department of Urology, Osaka University Hospital, Osaka, JapanSearch for more papers by this authorCorresponding Author
M. Namiki
Department of Urology, Osaka University Hospital, 1-1-50 Fukushima, Fukushima-ku, Osaka, 553 Japan
Toshinobu Seguchi, Etsuji Nakano, Hiroshi Kameoka. Shirou Takahara. Mikio Namiki, Michio Ishibashi and Akihiko Okuyama, Department of Urology, Osaka University Hospital, Osaka, JapanSearch for more papers by this authorCorresponding Author
M. Ishibashi
Department of Urology, Osaka University Hospital, 1-1-50 Fukushima, Fukushima-ku, Osaka, 553 Japan
Toshinobu Seguchi, Etsuji Nakano, Hiroshi Kameoka. Shirou Takahara. Mikio Namiki, Michio Ishibashi and Akihiko Okuyama, Department of Urology, Osaka University Hospital, Osaka, JapanSearch for more papers by this authorCorresponding Author
A. Okuyama
Department of Urology, Osaka University Hospital, 1-1-50 Fukushima, Fukushima-ku, Osaka, 553 Japan
Toshinobu Seguchi, Etsuji Nakano, Hiroshi Kameoka. Shirou Takahara. Mikio Namiki, Michio Ishibashi and Akihiko Okuyama, Department of Urology, Osaka University Hospital, Osaka, JapanSearch for more papers by this authorCorresponding Author
T. Seguchi M.D.
Department of Urology, Osaka University Hospital, 1-1-50 Fukushima, Fukushima-ku, Osaka, 553 Japan
Toshinobu Seguchi, Etsuji Nakano, Hiroshi Kameoka. Shirou Takahara. Mikio Namiki, Michio Ishibashi and Akihiko Okuyama, Department of Urology, Osaka University Hospital, Osaka, JapanSearch for more papers by this authorCorresponding Author
E. Nakano
Department of Urology, Osaka University Hospital, 1-1-50 Fukushima, Fukushima-ku, Osaka, 553 Japan
Toshinobu Seguchi, Etsuji Nakano, Hiroshi Kameoka. Shirou Takahara. Mikio Namiki, Michio Ishibashi and Akihiko Okuyama, Department of Urology, Osaka University Hospital, Osaka, JapanSearch for more papers by this authorCorresponding Author
H. Kameoka
Department of Urology, Osaka University Hospital, 1-1-50 Fukushima, Fukushima-ku, Osaka, 553 Japan
Toshinobu Seguchi, Etsuji Nakano, Hiroshi Kameoka. Shirou Takahara. Mikio Namiki, Michio Ishibashi and Akihiko Okuyama, Department of Urology, Osaka University Hospital, Osaka, JapanSearch for more papers by this authorCorresponding Author
S. Takahara
Department of Urology, Osaka University Hospital, 1-1-50 Fukushima, Fukushima-ku, Osaka, 553 Japan
Toshinobu Seguchi, Etsuji Nakano, Hiroshi Kameoka. Shirou Takahara. Mikio Namiki, Michio Ishibashi and Akihiko Okuyama, Department of Urology, Osaka University Hospital, Osaka, JapanSearch for more papers by this authorCorresponding Author
M. Namiki
Department of Urology, Osaka University Hospital, 1-1-50 Fukushima, Fukushima-ku, Osaka, 553 Japan
Toshinobu Seguchi, Etsuji Nakano, Hiroshi Kameoka. Shirou Takahara. Mikio Namiki, Michio Ishibashi and Akihiko Okuyama, Department of Urology, Osaka University Hospital, Osaka, JapanSearch for more papers by this authorCorresponding Author
M. Ishibashi
Department of Urology, Osaka University Hospital, 1-1-50 Fukushima, Fukushima-ku, Osaka, 553 Japan
Toshinobu Seguchi, Etsuji Nakano, Hiroshi Kameoka. Shirou Takahara. Mikio Namiki, Michio Ishibashi and Akihiko Okuyama, Department of Urology, Osaka University Hospital, Osaka, JapanSearch for more papers by this authorCorresponding Author
A. Okuyama
Department of Urology, Osaka University Hospital, 1-1-50 Fukushima, Fukushima-ku, Osaka, 553 Japan
Toshinobu Seguchi, Etsuji Nakano, Hiroshi Kameoka. Shirou Takahara. Mikio Namiki, Michio Ishibashi and Akihiko Okuyama, Department of Urology, Osaka University Hospital, Osaka, JapanSearch for more papers by this authorAbstract
We monitored serum BFP, a broad-spectrum tumor marker, in 36 patients with kidney transplantation. Scrum BFP was elevated in close association with acute rejection and dropped to a normal level after reversal of rejection. As Western blot analysis has revealed that BFP is present in the normal kidney, it is believed that serum BFP may be useful for the detection of various types of renal damage such as acute rejection.
References
- 1.Ishii M, Uattori M, Ohkura H, Tozawa T. Study on feto-neoplastic antigen. Proc Japanese Cancer Association, the 34th annual meeting, 1975: pp 173.
- 2.Ishii M. A new carcinoembryonic protein characterized by basic properly. Scand J Immunol 1978: (Suppl.) 8: 611.
- 3.Ishii M, Arai K, Takemori Y, et al. Production of Monoclonal Anti-Basic Fetoprotein (BFP) and Usefulness of Monoclonal Anti-BFP for Immunodiagnosis of Human Cancer. Tumor Res 1983: 18 (Special Issue): s75.
- 4.Harada K, Morishita S, Itani A, et al. Clinical evaluation of basic fetoprotein in testicular cancer. J Urol 1987: 138: 1178.
- 5.Gohji K, Ishii M, Nagata H, et al. Serum basic fetoprotein in patients with renal cell carcinoma. Cancer 1990: 65: 1405.
10.1002/1097-0142(19900315)65:6<1405::AID-CNCR2820650627>3.0.CO;2-5 CAS PubMed Web of Science® Google Scholar
- 6.Shitara M. Yoshioka H, Sakurabayashi I, Kawai T. Fundamental studies and the reference values of basic fetoprotein. Rinshou-Byouri 1988: 36: 1039.
- 7.Ishii M, Hattori N, Kato T, et al. Clinical evaluation on an enzyme immunoassay kit for basic fetoprotein (BFP): Clinical usefulness of BFP. Jpn J Cancer Chemother 1988: 15: 2107.
- 8.Ishii M. Clinical usefulness of basis fetoprotein for immunodiagnosis of human cancer. In: R Herbermann, ed. Compendium of Assays for Immunodiagnosis of Human Cancer, vol. 1. New York: Elsevier-/North-Holland Biomedical, 1979: p 45.
- 9.Yoshimura N, Oka T, Kahan BD. Sequential determinations of serum Interlcukin-6 levels as an immunodiagnostic tool to differentiate rejection from nephrotoxicity in renal allograft recipients. Transplantation 1991: 51: 172.
