Extract of Punica granatum inhibits skin photoaging induced by UVB irradiation
Hye Min Park MS
Department of Medical Science, Graduate School of East-West Medical Science, Kyung Hee University Global Campus, Giheung-Gu, Yongin-Si, Gyeonggi-Do, South Korea
Search for more papers by this authorEunjung Moon MS
Department of Medical Science, Graduate School of East-West Medical Science, Kyung Hee University Global Campus, Giheung-Gu, Yongin-Si, Gyeonggi-Do, South Korea
Search for more papers by this authorAe-Jung Kim PhD
Department of Food and Nutrition, Hyejeon College, Heongsung Gun, Choongnam, South Korea
Search for more papers by this authorMi Hyun Kim MS
Department of Medical Science, Graduate School of East-West Medical Science, Kyung Hee University Global Campus, Giheung-Gu, Yongin-Si, Gyeonggi-Do, South Korea
Search for more papers by this authorSanghee Lee PhD
Korea Food Research Institute, Bundang-Ku, Sungnam-Si, Gyeonggi-Do, South Korea
Search for more papers by this authorJung Bok Lee PhD
College of Pharmacy Sungkyunkwan University, Jangan-Gu, Suwon, Gyeonggi-do, South Korea
Search for more papers by this authorYong Kon Park PhD
Korea Food Research Institute, Bundang-Ku, Sungnam-Si, Gyeonggi-Do, South Korea
Search for more papers by this authorHyuk-Sang Jung OMD
College of Oriental Medicine, Kyung Hee University, Hoegi-Dong, Dongdaemun-Gu, Seoul, South Korea
Search for more papers by this authorYoon-Bum Kim OMD
College of Oriental Medicine, Kyung Hee University, Hoegi-Dong, Dongdaemun-Gu, Seoul, South Korea
Search for more papers by this authorSun Yeou Kim PhD
Department of Medical Science, Graduate School of East-West Medical Science, Kyung Hee University Global Campus, Giheung-Gu, Yongin-Si, Gyeonggi-Do, South Korea
East-West integrated Medical Science Research center, Kyung Hee University Global Campus, Giheung-Gu, Yongin-Si, Gyeonggi-Do, South Korea
Search for more papers by this authorHye Min Park MS
Department of Medical Science, Graduate School of East-West Medical Science, Kyung Hee University Global Campus, Giheung-Gu, Yongin-Si, Gyeonggi-Do, South Korea
Search for more papers by this authorEunjung Moon MS
Department of Medical Science, Graduate School of East-West Medical Science, Kyung Hee University Global Campus, Giheung-Gu, Yongin-Si, Gyeonggi-Do, South Korea
Search for more papers by this authorAe-Jung Kim PhD
Department of Food and Nutrition, Hyejeon College, Heongsung Gun, Choongnam, South Korea
Search for more papers by this authorMi Hyun Kim MS
Department of Medical Science, Graduate School of East-West Medical Science, Kyung Hee University Global Campus, Giheung-Gu, Yongin-Si, Gyeonggi-Do, South Korea
Search for more papers by this authorSanghee Lee PhD
Korea Food Research Institute, Bundang-Ku, Sungnam-Si, Gyeonggi-Do, South Korea
Search for more papers by this authorJung Bok Lee PhD
College of Pharmacy Sungkyunkwan University, Jangan-Gu, Suwon, Gyeonggi-do, South Korea
Search for more papers by this authorYong Kon Park PhD
Korea Food Research Institute, Bundang-Ku, Sungnam-Si, Gyeonggi-Do, South Korea
Search for more papers by this authorHyuk-Sang Jung OMD
College of Oriental Medicine, Kyung Hee University, Hoegi-Dong, Dongdaemun-Gu, Seoul, South Korea
Search for more papers by this authorYoon-Bum Kim OMD
College of Oriental Medicine, Kyung Hee University, Hoegi-Dong, Dongdaemun-Gu, Seoul, South Korea
Search for more papers by this authorSun Yeou Kim PhD
Department of Medical Science, Graduate School of East-West Medical Science, Kyung Hee University Global Campus, Giheung-Gu, Yongin-Si, Gyeonggi-Do, South Korea
East-West integrated Medical Science Research center, Kyung Hee University Global Campus, Giheung-Gu, Yongin-Si, Gyeonggi-Do, South Korea
Search for more papers by this authorAbstract
Background Punica granatum (pomegranate) is kind of a fruit consumed fresh or in beverage. It has been widely used in traditional medicine in various parts of the world. In this study, we examined the efficacy of a Punica granatum (PG) extract in protecting skin against UVB-induced damage using cultured human skin fibroblasts.
Methods A Korean red PG sample was used, and its effects classified according to if the PG source originated from the rind, seed and fruit. The polyphenol content of PG, which is known to prevent other adverse cutaneous effects of UV irradiation, was measured by GC-MS. The protective effects of PG on UVB-induced skin photoaging were examined by determining the level of procollagen type I and MMP-1 after UVB irradiation.
Results Based on the GC-MS quantitative analysis, catechin, quercetin, kaempferol, and equol were the predominant compounds detected in PG. In the changes of expression of procollagen type I and MMP-1 in UV irradiated human skin fibroblasts treated PG, especially extract prepared from rind, the synthesis of collagen was increased and the expression of MMP-1 was decreased.
Conclusion The major polyphenols in PG, particularly catechin, play a significant role in its photoprotective effects on UVB-induced skin damage.
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