Topical 5-aminolevulinic acid photodynamic therapy for the treatment of unilesional mycosis fungoides: a report of two cases and review of the literature

Esther Díez Recio MD, PhD

From the Departments of Dermatology and Pathology, University Hospital, Alcala de Henares University, Guadalajara, Spain

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Belen Zambrano MD,

Belen Zambrano MD

From the Departments of Dermatology and Pathology, University Hospital, Alcala de Henares University, Guadalajara, Spain

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Maria Luisa Alonso MD,

Maria Luisa Alonso MD

From the Departments of Dermatology and Pathology, University Hospital, Alcala de Henares University, Guadalajara, Spain

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Esther De Eusebio MD, PhD,

Esther De Eusebio MD, PhD

From the Departments of Dermatology and Pathology, University Hospital, Alcala de Henares University, Guadalajara, Spain

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Manuel Martín MD, PhD,

Manuel Martín MD, PhD

From the Departments of Dermatology and Pathology, University Hospital, Alcala de Henares University, Guadalajara, Spain

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Jesús Cuevas MD, PhD,

Jesús Cuevas MD, PhD

From the Departments of Dermatology and Pathology, University Hospital, Alcala de Henares University, Guadalajara, Spain

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Pedro Jaén MD, PhD,

Pedro Jaén MD, PhD

From the Departments of Dermatology and Pathology, University Hospital, Alcala de Henares University, Guadalajara, Spain

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Esther Díez Recio MD, PhD,

Esther Díez Recio MD, PhD

From the Departments of Dermatology and Pathology, University Hospital, Alcala de Henares University, Guadalajara, Spain

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Belen Zambrano MD,

Belen Zambrano MD

From the Departments of Dermatology and Pathology, University Hospital, Alcala de Henares University, Guadalajara, Spain

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Maria Luisa Alonso MD,

Maria Luisa Alonso MD

From the Departments of Dermatology and Pathology, University Hospital, Alcala de Henares University, Guadalajara, Spain

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Esther De Eusebio MD, PhD,

Esther De Eusebio MD, PhD

From the Departments of Dermatology and Pathology, University Hospital, Alcala de Henares University, Guadalajara, Spain

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Manuel Martín MD, PhD,

Manuel Martín MD, PhD

From the Departments of Dermatology and Pathology, University Hospital, Alcala de Henares University, Guadalajara, Spain

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Jesús Cuevas MD, PhD,

Jesús Cuevas MD, PhD

From the Departments of Dermatology and Pathology, University Hospital, Alcala de Henares University, Guadalajara, Spain

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Pedro Jaén MD, PhD,

Pedro Jaén MD, PhD

From the Departments of Dermatology and Pathology, University Hospital, Alcala de Henares University, Guadalajara, Spain

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First published: 28 March 2008

https://doi.org/10.1111/j.1365-4632.2008.03177.x

Citations: 38

Esther Díez Recio, MD, PhD C/Donantes de sangre s/n Hospital de Guadalajara Servicio de Dermatología Guadalajara 19002 Spain E-mail: [email protected]

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Abstract

Background Unilesional mycosis fungoides (MF) is a rare variant of cutaneous T-cell lymphoma (CTCL), characterized clinically by a solitary lesion and by histopathological features indistinguishable from multilesional MF. The photodynamic therapy (PDT) is a new and effective treatment of precancerous lesions and non-melanoma skin cancers. In recent years it has been used successfully for the treatment of MF.

Methods We present two cases of unilesional MF treated with 5-Aminolevulinic acid-PDT (ALA-PDT). We used twenty per cent ALA, applied topically to the lesion, and a well defined laser irradiation at 585 nm wavelength from C-Beam laser. Treatment was repeated three times at monthly intervals. Skin biopsies were taken before and after therapy.

Results Both patients showed clinical remission. The biopsies confirmed a regression of the infiltrate after treatment.

Conclusions PDT is effective and can be used successfully for MF treatment, particularly for patch and plaque stage MF, including unilesional MF.

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Volume47, Issue4

April 2008

Pages 410-413

Topical 5-aminolevulinic acid photodynamic therapy for the treatment of unilesional mycosis fungoides: a report of two cases and review of the literature

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Topical 5-aminolevulinic acid photodynamic therapy for the treatment of unilesional mycosis fungoides: a report of two cases and review of the literature

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