review
Microparticles, malignancy and thrombosis
Sharon Zahra,
Julia A. M. Anderson,
David Stirling,
Christopher A. Ludlam,
Sharon Zahra
College of Medicine and Veterinary Medicine, University of Edinburgh
Department of Clinical and Laboratory Haematology, Royal Infirmary of Edinburgh, Edinburgh, UK
Search for more papers by this authorJulia A. M. Anderson
College of Medicine and Veterinary Medicine, University of Edinburgh
Department of Clinical and Laboratory Haematology, Royal Infirmary of Edinburgh, Edinburgh, UK
Search for more papers by this authorDavid Stirling
College of Medicine and Veterinary Medicine, University of Edinburgh
Department of Clinical and Laboratory Haematology, Royal Infirmary of Edinburgh, Edinburgh, UK
Search for more papers by this authorChristopher A. Ludlam
College of Medicine and Veterinary Medicine, University of Edinburgh
Department of Clinical and Laboratory Haematology, Royal Infirmary of Edinburgh, Edinburgh, UK
Search for more papers by this authorSharon Zahra,
Julia A. M. Anderson,
David Stirling,
Christopher A. Ludlam,
Sharon Zahra
College of Medicine and Veterinary Medicine, University of Edinburgh
Department of Clinical and Laboratory Haematology, Royal Infirmary of Edinburgh, Edinburgh, UK
Search for more papers by this authorJulia A. M. Anderson
College of Medicine and Veterinary Medicine, University of Edinburgh
Department of Clinical and Laboratory Haematology, Royal Infirmary of Edinburgh, Edinburgh, UK
Search for more papers by this authorDavid Stirling
College of Medicine and Veterinary Medicine, University of Edinburgh
Department of Clinical and Laboratory Haematology, Royal Infirmary of Edinburgh, Edinburgh, UK
Search for more papers by this authorChristopher A. Ludlam
College of Medicine and Veterinary Medicine, University of Edinburgh
Department of Clinical and Laboratory Haematology, Royal Infirmary of Edinburgh, Edinburgh, UK
Search for more papers by this authorDr Sharon Zahra, Department of Haematology, Royal Infirmary of Edinburgh, 16 Little France Crescent, Edinburgh EH16 4SA, UK. E-mail: [email protected]
Summary
Microparticles (MPs) are considered to be important biological effectors of several different physiological and pathological processes. There is increasing evidence of their role in haemostasis and thrombosis, and also of their importance in cancer cell survival, invasiveness and metastasis. The level of circulating MPs has been assessed in many different disease states, and there are reports that patients with malignancy and patients with thrombosis have increased levels of circulating MPs and MP-dependent thrombogenic potential. Research into the function and effect of MPs is currently hampered by a lack of standardization in the methods used to identify and quantify them. As these methods improve it is likely that MP assays will be of use both diagnostically and therapeutically in the future.
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