Deciphering the molecular basis of venous thromboembolism: where are we and where should we go?
Pierre-Emmanuel Morange,
David-Alexandre Tregouet,
Pierre-Emmanuel Morange
INSERM UMR S626, Faculty of Medicine, University of the Mediterranean, Marseille
Search for more papers by this authorDavid-Alexandre Tregouet
INSERM UMR S937, Pierre and Marie Curie University (UPMC), Paris, France
Search for more papers by this authorPierre-Emmanuel Morange,
David-Alexandre Tregouet,
Pierre-Emmanuel Morange
INSERM UMR S626, Faculty of Medicine, University of the Mediterranean, Marseille
Search for more papers by this authorDavid-Alexandre Tregouet
INSERM UMR S937, Pierre and Marie Curie University (UPMC), Paris, France
Search for more papers by this authorPierre-Emmanuel Morange, Lab. Hematology CHU Timone, 264 rue Saint-Pierre, Marseille 13385 cedex 05, France. E-mail: [email protected]
Summary
Venous thromboembolism (VTE) is a frequent disease that has a major genetic component of risk. However, known identified genetic risk factors account for <30% of idiopathic (without any environmental origin) VTE cases. This article aims to review the lessons learnt during recent decades in the field of the genetics of VTE, describe the present state-of-art methods and discuss promising themes for finding new susceptibility loci.
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