Updates from the British Association of Dermatologists 89th Annual Meeting, 7–10 July 2009, Glasgow, U.K.
A.B. Alexandroff
Department of Dermatology, Leicester Royal Infirmary, Leicester LE1 5WW, U.K.
Search for more papers by this authorC. Flohr
Department of Dermatology, Queens Medical Centre Campus, Nottingham University Hospitals NHS Trust, Nottingham NG7 2UH, U.K.
Search for more papers by this authorG.A. Johnston
Department of Dermatology, Leicester Royal Infirmary, Leicester LE1 5WW, U.K.
Search for more papers by this authorA.B. Alexandroff
Department of Dermatology, Leicester Royal Infirmary, Leicester LE1 5WW, U.K.
Search for more papers by this authorC. Flohr
Department of Dermatology, Queens Medical Centre Campus, Nottingham University Hospitals NHS Trust, Nottingham NG7 2UH, U.K.
Search for more papers by this authorG.A. Johnston
Department of Dermatology, Leicester Royal Infirmary, Leicester LE1 5WW, U.K.
Search for more papers by this authorConflicts of interestA.B.A. is the Clinical Lead for Dermatology for LNR CLRN. A.B.A. acknowledges receiving educational support from Merck Serono, Basilea, LEO Pharma and Almirall.
Summary
This is a synopsis of the significant research and clinical papers presented at the British Association of Dermatologists meeting held during 7–10 July 2009 in Glasgow, U.K. The conference and satellite symposia highlighted the recent biological, epidemiological and therapeutic advances in dermatology. This report is not meant as a substitute for reading the conference proceedings and related references quoted in this article.
References
- 1 Telfer NR, Colver GB, Morton CA. Guidelines for the management of basal cell carcinoma. Br J Dermatol 2008; 159: 35–48.
- 2 Van Hattem S, Aarts MJ, Louwman WJ et al. Increase in basal cell carcinoma incidence steepest in individuals with high socioeconomic status: results of a cancer registry study in the Netherlands. Br J Dermatol 2009; 161: 840–5.
- 3 Ulrich C, Jurgensen JS, Degen A et al. Prevention of non-melanoma skin cancer in organ transplant patients by regular use of a sunscreen: a 24 months, prospective, case–control study. Br J Dermatol 2009; 161 (Suppl. 3): 78–84.
- 4 Ho WL, Murphy GM. Update on the pathogenesis of post-transplant skin cancer in renal transplant recipients. Br J Dermatol 2008; 158: 217–24.
- 5 Alexandroff A, Sinclair S. Use of topical imiquimod for treating of multiple basal cell carcinomas of scalp after X-ray treatment for tinea capitis. Br J Dermatol 2005; 153 (Suppl. 1): 25 (Abstract).
- 6 Bielsa I, Soria X, Esteve M et al. Population-based incidence of basal cell carcinoma in a Spanish Mediterranean area. Br J Dermatol 2009; 161: 1341–6.
- 7 Skellett AM, Wright KA, Greenberg DC, Levell NJ. Increasing incidence of basal cell carcinoma in the under 30s in the U.K. Br J Dermatol 2009; 161 (Suppl. 1): 101 (Abstract).
- 8 Shelley J, Lawrence C. Aggressive growth pattern basal cell carcinoma and long-term methotrexate therapy. Br J Dermatol 2009; 161 (Suppl. 1): 109 (Abstract).
- 9 Van Haren R, Feldman D, Sinha AA. Systematic comparison of nonmelanoma skin cancer microarray datasets reveals lack of consensus genes. Br J Dermatol 2009; 161: 1278–87.
- 10 Kern JS, Gruninger G, Imsak R et al. Forty-two novel COL7A1 mutations and the role of a frequent single nucleotide polymorphism in the MMP1 promoter in modulation of disease severity in a large European dystrophic epidermolysis bullosa cohort. Br J Dermatol 2009; 161: 1089–97.
- 11 Geng A, Weinstock MA, Hall R et al. Tolerability of high-dose topical tretinoin: the Veterans Affairs Topical Tretinoin Chemoprevention Trial. Br J Dermatol 2009; 161: 918–24.
- 12 Toll A, Salgado R, Yebenes M et al. MYC gene numerical aberrations in actinic keratosis and cutaneous squamous cell carcinoma. Br J Dermatol 2009; 161: 1112–18.
- 13 Kreuter A, Gambichler T, Pfister H et al. Diversity of human papillomavirus types in periungual squamous cell carcinoma. Br J Dermatol 2009; 161: 1262–9.
- 14 Prior SL, Griffiths AP, Lewis PD. A study of mitochondrial DNA D-loop mutations and p53 status in nonmelanoma skin cancer. Br J Dermatol 2009; 161: 1067–71.
- 15 Varga E, Kiss M, Szabo K et al. Detection of Merkel cell polyomavirus DNA in Merkel cell carcinomas. Br J Dermatol 2009; 161: 930–2.
- 16 Cicarma E, Tuorkey M, Juzeniene A et al. Calcitriol treatment improves methyl aminolaevulinate-based photodynamic therapy in human squamous cell carcinoma A431 cells. Br J Dermatol 2009; 161: 413–18.
- 17 Mackintosh LJ, De Koning MN, Quint WG et al. Presence of beta human papillomaviruses in nonmelanoma skin cancer from organ transplant recipients and immunocompetent patients in the West of Scotland. Br J Dermatol 2009; 161: 56–62.
- 18 Downs AM, Bower CB, Oliver DA et al. Methyl aminolaevulinate–photodynamic therapy for actinic keratoses, squamous cell carcinoma in situ and superficial basal cell carcinoma employing a square wave intense pulsed light device for photoactivation. Br J Dermatol 2009; 161: 189–90.
- 19 Attili SK, Lesar A, McNeill A et al. An open pilot study of ambulatory photodynamic therapy using a wearable low-irradiance organic light-emitting diode light source in the treatment of nonmelanoma skin cancer. Br J Dermatol 2009; 161: 170–3.
- 20 Hida Y, Kubo Y, Arase S. Activation of fibroblast growth factor receptor 3 and oncogene-induced senescence in skin tumours. Br J Dermatol 2009; 160: 1258–63.
- 21 Hartmann-Petersen S, Tammi RH, Tammi MI et al. Depletion of cell surface CD44 in nonmelanoma skin tumours is associated with increased expression of matrix metalloproteinase 7. Br J Dermatol 2009; 160: 1251–7.
- 22 Haque Hussain SS, Shams N, Garioch JJ. Managing squamous cell carcinomas: audit on the mode of referral and adequacy of surgical excision. Br J Dermatol 2009; 160: 224–5.
- 23 Chen SJ, Nakahara T, Takahara M et al. Activation of the mammalian target of rapamycin signalling pathway in epidermal tumours and its correlation with cyclin-dependent kinase 2. Br J Dermatol 2009; 160: 442–5.
- 24 Morton CA, McKenna KE, Rhodes LE. Guidelines for topical photodynamic therapy: update. Br J Dermatol 2008; 159: 1245–66.
- 25 Hearn RM, Kerr AC, Rahim KF et al. Incidence of skin cancers in 3867 patients treated with narrow-band ultraviolet B phototherapy. Br J Dermatol 2008; 159: 931–5.
- 26 Alexandrescu DT, Dasanu CA, Farzanmehr H et al. Development of squamous cell carcinomas in Darier disease: a new model for skin carcinogenesis? Br J Dermatol 2008; 159: 1378–80.
- 27 Garg S, Carroll RP, Walker RG et al. Skin cancer surveillance in renal transplant recipients: re-evaluation of U.K. practice and comparison with Australian experience. Br J Dermatol 2009; 160: 177–9.
- 28 Smith LC, Cox NH, Dawn G. Shave biopsy without local anaesthetic to diagnose basal cell carcinoma and other skin tumours prior to definitive treatment: analysis of 109 lesions. Br J Dermatol 2009; 160: 180–2.
- 29 Chen S, Takahara M, Kido M et al. Increased expression of an epidermal stem cell marker, cytokeratin 19, in cutaneous squamous cell carcinoma. Br J Dermatol 2008; 159: 952–5.
- 30 Jensen AO, Bautz A, Olesen AB et al. Mortality in Danish patients with nonmelanoma skin cancer, 1978–2001. Br J Dermatol 2008; 159: 419–25.
- 31 Heal CF, Raasch BA, Buettner PG et al. Accuracy of clinical diagnosis of skin lesions. Br J Dermatol 2008; 159: 661–8.
- 32 Yip L, Ryan A, Sinclair R. Squamous cell carcinoma arising within folliculitis decalvans. Br J Dermatol 2008; 159: 481–2.
- 33 Waterboer T, Abeni D, Sampogna F et al. Serological association of beta and gamma human papillomaviruses with squamous cell carcinoma of the skin. Br J Dermatol 2008; 159: 457–9.
- 34 Calzavara-Pinton PG, Venturini M, Sala R et al. Methylaminolaevulinate-based photodynamic therapy of Bowen’s disease and squamous cell carcinoma. Br J Dermatol 2008; 159: 137–44.
- 35 Brown VL, Farrant PB, Turner RJ et al. Multiple aggressive squamous skin cancers in association with nonbullous congenital ichthyosiform erythroderma. Br J Dermatol 2008; 158: 1125–8.
- 36 Alexandroff AB, Harman KE. Blistering skin disorders: an evidence-based update Conference report. Br J Dermatol 2009; 160: 502–4.
- 37 Pacifico A, Goldberg LH, Peris K et al. Loss of CDKN2A and p14ARF expression occurs frequently in human nonmelanoma skin cancers. Br J Dermatol 2008; 158: 291–7.
- 38 Kivisaari AK, Kallajoki M, Mirtti T et al. Transformation-specific matrix metalloproteinases (MMP)-7 and MMP-13 are expressed by tumour cells in epidermolysis bullosa-associated squamous cell carcinomas. Br J Dermatol 2008; 158: 778–85.
- 39 Alexandroff AB, Burd R. Footprints of the EADV: a meeting report from the 17th Congress of the European Academy of Dermatology and Venereology. Br J Dermatol 2009; 160: 938–45.
- 40 Prowse DM, Ktori EN, Chandrasekaran D et al. Human papillomavirus-associated increase in p16INK4A expression in penile lichen sclerosus and squamous cell carcinoma. Br J Dermatol 2008; 158: 261–5.
- 41 Young LC, Listgarten J, Trotter MJ et al. Evidence that dysregulated DNA mismatch repair characterizes human nonmelanoma skin cancer. Br J Dermatol 2008; 158: 59–69.
- 42 Salmon P, Hussein W, Mortimer N. Desmoplastic squamous cell carcinoma: an underemphasized, locally aggressive variant. Br J Dermatol 2009; 161 (Suppl. 1): 101 (Abstract).
- 43 De Berker DAR, Milne J. Consensus guidance on histological margins in variants of cutaneous squamous cell carcinoma. Br J Dermatol 2009; 161 (Suppl. 1): 102 (Abstract).
- 44 Alexandroff AB, Graham-Brown RAC. Report from the 67th Annual Meeting of American Academy of Dermatology. Br J Dermatol 2010; 162: 12–21.
- 45 Nowecki ZI, Rutkowski P, Kulik J et al. Molecular and biochemical testing in stage III melanoma: multimarker reverse transcriptase–polymerase chain reaction assay of lymph fluid after lymph node dissection and preoperative serum lactate dehydrogenase level. Br J Dermatol 2008; 159: 597–605.
- 46 Green DS, Dalgleish AG, Belonwu N et al. Topical imiquimod and intralesional interleukin-2 increase activated lymphocytes and restore the Th1/Th2 balance in patients with metastatic melanoma. Br J Dermatol 2008; 159: 606–14.
- 47 Vestergaard ME, Macaskill P, Holt PE et al. Dermoscopy compared with naked eye examination for the diagnosis of primary melanoma: a meta-analysis of studies performed in a clinical setting. Br J Dermatol 2008; 159: 669–76.
- 48 Guitera P, Li LX, Crotty K et al. Melanoma histological Breslow thickness predicted by 75-MHz ultrasonography. Br J Dermatol 2008; 159: 364–9.
- 49 Bories N, Dalle S, Debarbieux S et al. Dermoscopy of fully regressive cutaneous melanoma. Br J Dermatol 2008; 158: 1224–9.
- 50 Debarbieux S, Ronger-Salve S, Dalle S et al. Dermoscopy of desmoplastic melanoma: report of six cases. Br J Dermatol 2008; 159: 360–3.
- 51 Pfohler C, Schmaltz R, Graeber S et al. ‘Autoimmunity’ is not always associated with prolonged survival in melanoma patients. Br J Dermatol 2008; 159: 735–6.
- 52 Einwachter-Thompson J, MacKie RM. An evidence base for reconsidering current follow-up guidelines for patients with cutaneous melanoma less than 0.5 mm thick at diagnosis. Br J Dermatol 2008; 159: 337–41.
- 53 Argenziano G, Mordente I, Ferrara G et al. Dermoscopic monitoring of melanocytic skin lesions: clinical outcome and patient compliance vary according to follow-up protocols. Br J Dermatol 2008; 159: 331–6.
- 54 Gerger A, Hofmann-Wellenhof R, Langsenlehner U et al. In vivo confocal laser scanning microscopy of melanocytic skin tumours: diagnostic applicability using unselected tumour images. Br J Dermatol 2008; 158: 329–33.
- 55 Lipoff JB, Scope A, Dusza SW et al. Complex dermoscopic pattern: a potential risk marker for melanoma. Br J Dermatol 2008; 158: 821–4.
- 56 Hall PN, Hunter JE, Walter FM et al. Use of a spectrophotometric intracutaneous analysis device in the real-time diagnosis of melanoma. Br J Dermatol 2008; 158: 420–1.
- 57 Tao J, Li Y, Liu YQ et al. Expression of transporters associated with antigen processing and human leucocyte antigen class I in malignant melanoma and its association with prognostic factors. Br J Dermatol 2008; 158: 88–94.
- 58 Boulaiz H, Prados J, Melguizo C et al. Tumour malignancy loss and cell differentiation are associated with induction of gef gene in human melanoma cells. Br J Dermatol 2008; 159: 370–8.
- 59 Lin J, Hocker TL, Singh M et al. Genetics of melanoma predisposition. Br J Dermatol 2008; 159: 286–91.
- 60 Sini MC, Manca A, Cossu A et al. Molecular alterations at chromosome 9p21 in melanocytic naevi and melanoma. Br J Dermatol 2008; 158: 243–50.
- 61 Alexandroff AB, Gibbs S. Skin deep: report from the annual meeting of the British Society for Investigative Dermatology. Exp Oncol 2007; 29: 162–3.
- 62 Muchemwa FC, Ma D, Inoue Y et al. Constitutive activation of the phosphatidyl inositol 3 kinase signalling pathway in acral lentiginous melanoma. Br J Dermatol 2008; 158: 411–13.
- 63 Alexandroff AB, Jackson AM, Paterson T et al. Role for CD40–CD40 ligand interactions in the immune response to solid tumours. Mol Immunol 2000; 37: 515–26.
- 64 Da Forno PD, Fletcher A, Pringle JH et al. Understanding spitzoid tumours: new insights from molecular pathology. Br J Dermatol 2008; 158: 4–14.
- 65
Alexandroff AB,
Da Forno PD,
Johnston GA.
Lack of significance of sentinel lymph node biopsy for the prognosis and management of the atypical Spitz tumor of uncertain biologic potential.
Expert Rev Dermatol
2009; 215–7.
10.1586/edm.09.15 Google Scholar
- 66 Alexandroff AB, Robins RA, Murray A et al. Tumour immunology: false hopes – new horizons? Immunol Today 1998; 19: 247–50.
- 67 Alexandroff AB, McIntyre CA, Porter JC et al. Sticky and smelly issues: lessons on tumour cell and leucocyte trafficking, gene and immunotherapy of cancer. Br J Cancer 1998; 77: 1806–11.
- 68 Alexandroff AB. Once more unto the breach. Inaugural meeting of the British Society for Immunology Tumour Immunology Affinity Group. Cancer Immunol Immunother 1996; 43: 254–5.
- 69 Alexandroff AB, Dalgleish AG. Cancer biologists hit the road. Molecular genetics of cancer: Second Joint Conference of the American Association for Cancer Research and the European Association for Cancer Research. Oxford, UK, 9–13 September 1997. Cancer Gene Therapy Symposium. London, UK, 23–24 June 1997. Mol Med Today 1997; 3: 524–7.
- 70 Fusi A, Ochsenreither S, Busse A et al. Stem cell marker nestin expression in peripheral blood of patients with melanoma. Br J Dermatol 2010; (in press).
- 71 Socrier Y, Lauwers-Cances V, Lamant L et al. Histological regression in primary melanoma: not a predictor of sentinel lymph node metastasis in a cohort of 397 patients. Br J Dermatol 2010; 162: 830–4.
- 72 MacKie RM. Vitamin D in treated melanoma patients on follow up. Br J Dermatol 2010; 162: 697.
- 73 Nan H, Qureshi AA, Han J. Melanoma susceptibility variants on chromosome 20q11.22 are associated with pigmentary traits and the risk of nonmelanoma skin cancer. Br J Dermatol 2010; 162: 461–3.
- 74 Phan A, Dalle S, Touzet S et al. Dermoscopic features of acral lentiginous melanoma in a large series of 110 cases in a white population. Br J Dermatol 2010; 162: 765–71.
- 75 Nguyen LP, Emley A, Wajapeyee N et al. BRAF V600E mutation and the tumour suppressor IGFBP7 in atypical genital naevi. Br J Dermatol 2010; 162: 677–80.
- 76 De Giorgi V, Sestini S, Grazzini M et al. Prevalence and distribution of melanocytic naevi on the scalp: a prospective study. Br J Dermatol 2010; 162: 345–9.
- 77 Pagès C, Robert C, Thomas L et al. Management and outcome of metastatic melanoma during pregnancy. Br J Dermatol 2010; 162: 274–81.
- 78 Dewan P, Jawad A, Goldsmith P et al. Melanoma in patients with rheumatoid arthritis treated with antitumour necrosis factor: cause or coincidence? Report of two cases. Br J Dermatol 2009; 161: 1412–14.
- 79 Shuster S. Malignant melanoma: how error amplification by screening creates spurious disease. Br J Dermatol 2009; 161: 977–9.
- 80 Singh S, Kaye S, Gore ME et al. The role of human endogenous retroviruses in melanoma. Br J Dermatol 2009; 161: 1225–31.
- 81 Argenziano G, Kittler H, Ferrara G et al. Slow-growing melanoma: a dermoscopy follow-up study. Br J Dermatol 2010; 162: 267–73.
- 82 Sinclair C, Foley P. Skin cancer prevention in Australia. Br J Dermatol 2009; 161 (Suppl. 3): 116–23.
- 83 Autier P. Sunscreen abuse for intentional sun exposure. Br J Dermatol 2009; 161 (Suppl. 3): 40–5.
- 84 Gavin A, Donnelly C, Devlin A et al. Public at risk: a survey of sunbed parlour operating practices in Northern Ireland. Br J Dermatol 2010; 162: 627–32.
- 85 Berneburg M, Surber C. Children and sun protection. Br J Dermatol 2009; 161 (Suppl. 3): 33–9.
- 86 Diffey BL. Sunscreens as a preventative measure in melanoma: an evidence-based approach or the precautionary principle? Br J Dermatol 2009; 161 (Suppl. 3): 25–7.
- 87 Aulbert W, Parpart C, Schulz-Hornbostel R et al. Certification of sun protection practices in a German child day-care centre improves children’s sun protection – the ‘SunPass’ pilot study. Br J Dermatol 2009; 161 (Suppl. 3): 5–12.
- 88 Menzies SW, Emery J, Staples M et al. Impact of dermoscopy and short-term sequential digital dermoscopy imaging for the management of pigmented lesions in primary care: a sequential intervention trial. Br J Dermatol 2009; 161: 1270–7.
- 89 Ludgate MW, Fullen DR, Lee J et al. The atypical Spitz tumor of uncertain biologic potential: a series of 67 patients from a single institution. Cancer 2009; 115: 631–41.
- 90 Ludgate MW, Fullen DR, Lee J et al. Animal-type melanoma: a clinical and histopathological study of 22 cases from a single institution. Br J Dermatol 2010; 162: 129–36.
- 91 Jennings L, Murphy GM. Predicting outcome in melanoma: where are we now? Br J Dermatol 2009; 161: 496–503.
- 92 Garcia-Cruz A, Flórez A, De La Torre-Fraga C, Cruces Prado M. Observational cross-sectional study comparing Breslow thickness of melanoma arising from naevi and melanoma de novo. Br J Dermatol 2009; 161: 700–2.
- 93 Ahlgrimm-Siess V, Massone C, Scope A et al. Reflectance confocal microscopy of facial lentigo maligna and lentigo maligna melanoma: a preliminary study. Br J Dermatol 2009; 161: 1307–16.
- 94 Borges AL, Cuellar F, Puig-Butille JA et al. CDKN2A mutations in melanoma families from Uruguay. Br J Dermatol 2009; 161: 536–41.
- 95 Gu F, Qureshi AA, Kraft P et al. Polymorphisms in genes involved in DNA repair, cell growth, oxidative stress and inflammatory response, and melanoma risk. Br J Dermatol 2009; 161: 209–12.
- 96 Redpath M, Marques CM, Dibden C et al. Ibuprofen and hydrogel-released ibuprofen in the reduction of inflammation-induced migration in melanoma cells. Br J Dermatol 2009; 161: 25–33.
- 97 Da Forno PD, Pringle JH, Fletcher A et al. BRAF, NRAS and HRAS mutations in spitzoid tumours and their possible pathogenetic significance. Br J Dermatol 2009; 161: 364–72.
- 98 Werzowa J, Cejka D, Fuereder T et al. Suppression of mTOR complex 2-dependent AKT phosphorylation in melanoma cells by combined treatment with rapamycin and LY294002. Br J Dermatol 2009; 160: 955–64.
- 99 Rajpara S, Woo P, Muller F et al. The role of conventional naked eye examination, dermoscopy and digital dermoscopy follow-up in the management of melanocytic skin lesions: a prospective study. Br J Dermatol 2009; 161 (Suppl. 1): 102 (Abstract).
- 100 Cunningham C, Jones E, McMenamin M, Ormond P. Audit of frozen-section histological margins in a newly established Mohs micrographic surgery unit. Br J Dermatol 2009; 161 (Suppl. 1): 103 (Abstract).
- 101 Lateo S, Langtry JAA. Secondary intention healing for surgical wounds on the dorsum of the hands. Br J Dermatol 2009; 161 (Suppl. 1): 103–4 (Abstract).
- 102 De Berker DAR, Piraccini BM, Richert B. Subungual pyogenic granuloma: recognition and management. Br J Dermatol 2009; 161 (Suppl. 1): 104 (Abstract).
- 103 Al-Rawi H, Lawrence CM. Lymphatic leak and lymphocoele development after simple cutaneous surgery. Br J Dermatol 2009; 161 (Suppl. 1): 105 (Abstract).
- 104 Taher ZA, Lauzon G, Maguiness S et al. Analysis of interleukin-10 levels in lesions of vitiligo following treatment with topical tacrolimus. Br J Dermatol 2009; 161: 654–9.
- 105 Kostopoulou P, Jouary T, Quintard B et al. Objective vs. subjective factors in the psychological impact of vitiligo: the experience from a French referral centre. Br J Dermatol 2009; 161: 128–33.
- 106 Radtke MA, Schafer I, Gajur A et al. Willingness-to-pay and quality of life in patients with vitiligo. Br J Dermatol 2009; 161: 134–9.
- 107 Gawkrodger DJ, Ormerod AD, Shaw L et al. Guideline for the diagnosis and management of vitiligo. Br J Dermatol 2008; 159: 1051–76.
- 108 Linthorst Homan MW, De Korte J, Grootenhuis MA et al. Impact of childhood vitiligo on adult life. Br J Dermatol 2008; 159: 915–20.
- 109 Sampogna F, Raskovic D, Guerra L et al. Identification of categories at risk for high quality of life impairment in patients with vitiligo. Br J Dermatol 2008; 159: 351–9.
- 110 Holla AP, Sahni K, Parsad D, Kanwar AJ. Phosphate-buffered saline as an effective alternate to melanocyte media in autologous noncultured melanocyte transplantation. Br J Dermatol 2009; 161 (Suppl. 1): 105 (Abstract).
- 111 Madan V, Ferguson J, August PJ. Carbon dioxide laser treatment of rhinophyma: a review of 124 patients. Br J Dermatol 2009; 161 (Suppl. 1): 105–6 (Abstract).
- 112 Madan V, Ferguson JE, August PJ. Carbon dioxide laser treatment of rhinophyma: a review of 124 patients. Br J Dermatol 2009; 161: 814–18.
- 113 Walsh SA, Holme SA. Acne successfully treated with acitretin in a patient with peanut allergy. Reply. Br J Dermatol 2008; 159: 1208–9 (Letter).
- 114 Langner A, Chu A, Goulden V et al. A randomized, single-blind comparison of topical clindamycin + benzoyl peroxide and adapalene in the treatment of mild to moderate facial acne vulgaris. Br J Dermatol 2008; 158: 122–9.
- 115 Simonart T, Dramaix M, De Maertelaer V. Efficacy of tetracyclines in the treatment of acne vulgaris: a review. Br J Dermatol 2008; 158: 208–16.
- 116 Azoulay L, Oraichi D, Bérard A. Isotretinoin therapy and the incidence of acne relapse: a nested case–control study. Br J Dermatol 2007; 157: 1240–8.
- 117 Tan HH, Tan AW, Barkham T et al. Community-based study of acne vulgaris in adolescents in Singapore. Br J Dermatol 2007; 157: 547–51.
- 118 Layton AM, Eady EA. Benzoyl peroxide and adapalene fixed combination: a novel agent for acne. Br J Dermatol 2009; 161: 971–6.
- 119 Layton AM, Dréno B, Gollnick H et al. Isotretinoin therapy and the incidence of acne relapse: a nested case–control study. Br J Dermatol 2009; 160: 217–18 (Letter).
- 120 Hogewoning AA, Koelemij I, Amoah AS et al. Prevalence and risk factors of inflammatory acne vulgaris in rural and urban Ghanaian schoolchildren. Br J Dermatol 2009; 161: 475–7.
- 121 Gollnick HP, Draelos Z, Glenn MJ et al. Adapalene–benzoyl peroxide, a unique fixed-dose combination topical gel for the treatment of acne vulgaris: a transatlantic, randomized, double-blind, controlled study in 1670 patients. Br J Dermatol 2009; 161: 1180–9.
- 122 Darne S, Hiscutt E, Seukeran DC. Treatment of inflammatory acne with a 1450-nm smoothbeam diode laser: a split-face randomized single-blinded controlled trial. Br J Dermatol 2009; 161 (Suppl. 1): 106 (Abstract).
- 123 Kotz EA, Anderson D, Thiers BH. Cutaneous T-cell lymphoma. J Eur Acad Dermatol Venereol 2003; 17: 131–7.
- 124 Gardner JM, Evans KG, Musiek A et al. Update on treatment of cutaneous T-cell lymphoma. Curr Opin Oncol 2009; 21: 131–7.
- 125 Agar N, Morris S, Russell-Jones R et al. Case report of four patients with erythrodermic cutaneous T-cell lymphoma and severe photosensitivity mimicking chronic actinic dermatitis. Br J Dermatol 2009; 160: 698–703.
- 126 Requena L, Gonzalez-Guerra E, Angulo J et al. Anetodermic mycosis fungoides: a new clinicopathological variant of mycosis fungoides. Br J Dermatol 2008; 158: 157–62.
- 127 Dummer R, Geertsen R, Ludwig E et al. Sézary syndrome, T-helper 2 cytokines and accessory factor-1 (AF-1). Leuk Lymphoma 1998; 28: 515–22.
- 128 Goeldel AL, Cornillet-Lefebvre P, Durlach A et al. T-cell receptor gamma gene rearrangement in cutaneous T-cell lymphoma: comparative study of polymerase chain reaction with denaturing gradient gel electrophoresis and GeneScan analysis. Br J Dermatol 2010; 162: 822–9.
- 129 Okada S, Nannya Y, Ota S et al. Cutaneous T-cell lymphoma (mycosis fungoides) relapsed with different immunological phenotype after bone marrow transplant. Br J Dermatol 2010; 162: 229–30.
- 130 Nikolaou VA, Papadavid E, Katsambas A et al. Clinical characteristics and course of CD8+ cytotoxic variant of mycosis fungoides: a case series of seven patients. Br J Dermatol 2009; 161: 826–30.
- 131 Morizane S, Setsu N, Yamamoto T et al. Ichthyosiform eruptions in association with primary cutaneous T-cell lymphomas. Br J Dermatol 2009; 161: 115–20.
- 132 Benner MF, Jansen PM, Meijer CJLM, Willemze R. Diagnostic and prognostic evaluation of phenotypic markers TRAF1, MUM1, BCL2 and CD15 in cutaneous CD30-positive lymphoproliferative disorders. Br J Dermatol 2009; 161: 121–7.
- 133 Hernandez-Machin B, De Misa RF, Montenegro T et al. MUM1 expression does not differentiate primary cutaneous anaplastic large-cell lymphoma and lymphomatoid papulosis. Br J Dermatol 2009; 160: 713.
- 134 Boussault P, Tucker ML, Weschler J et al. Primary cutaneous CD4+ small/medium-sized pleomorphic T-cell lymphoma associated with an annular elastolytic giant cell granuloma. Br J Dermatol 2009; 160: 1126–8.
- 135 Oshima H, Matsuzaki Y, Takeuchi S et al. CD20+ primary cutaneous T-cell lymphoma presenting as a solitary extensive plaque. Br J Dermatol 2009; 160: 894–6.
- 136 Lee JH, Cheng AL, Lin CW et al. Multifocal primary cutaneous CD30+ anaplastic large cell lymphoma responsive to thalidomide: the molecular mechanism and the clinical application. Br J Dermatol 2009; 160: 887–9.
- 137 Nieto-Rementeria N, Perez-Yarza G, Boyano MD et al. Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. Br J Dermatol 2009; 160: 519–26.
- 138 Choi YL, Park JH, Namkung JH et al. Extranodal NK/T-cell lymphoma with cutaneous involvement: ‘nasal’ vs ‘nasal-type’ subgroups – a retrospective study of 18 patients. Br J Dermatol 2009; 160: 333–7.
- 139 Watabe D, Kanno H, Inoue-Narita T et al. A case of primary cutaneous natural killer/T-cell lymphoma, nasal type, with indolent clinical course: monoclonal expansion of Epstein–Barr virus genome correlating with the terminal aggressive behaviour. Br J Dermatol 2009; 160: 205–7.
- 140 Wozniak MB, Tracey L, Ortiz-Romero PL et al. Psoralen plus ultraviolet A ± interferon-alpha treatment resistance in mycosis fungoides: the role of tumour microenvironment, nuclear transcription factor-kappaB and T-cell receptor pathways. Br J Dermatol 2009; 160: 92–102.
- 141 Agar N, Whittaker SJ. Folliculotropic mycosis fungoides (stage IIA) progressing to Sézary syndrome: a case report. Br J Dermatol 2008; 159: 1197–9.
- 142 Massone C, Crisman G, Kerl H et al. The prognosis of early mycosis fungoides is not influenced by phenotype and T-cell clonality. Br J Dermatol 2008; 159: 881–6.
- 143 Kempf W, Kutzner H, Cozzio A et al. MUM1 expression in cutaneous CD30+ lymphoproliferative disorders: a valuable tool for the distinction between lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma. Br J Dermatol 2008; 158: 1280–7.
- 144 Sampogna F, Frontani M, Baliva G et al. Quality of life and psychological distress in patients with cutaneous lymphoma. Br J Dermatol 2009; 160: 815–22.
- 145 Bakis-Petsoglou S, Whittaker SJ, Tan SY. Proportion of regulatory T cells in the cutaneous infiltrate of 27 patients with mycosis fungoides: a retrospective case series. Br J Dermatol 2009; 161 (Suppl. 1): 58 (Abstract).
- 146 Agar N, Wedgeworth E, Scarisbrick J et al. Survival outcomes and prognostic factors in mycosis fungoides/Sézary syndrome: a comparison of the AJCC staging system with the revised ISCL/EORTC proposal. Br J Dermatol 2009; 161 (Suppl. 1): 1 (Abstract).
- 147 Birnie A, Thomas C, Motley RJ. Management of basal cell carcinoma around the external jugular vein. Br J Dermatol 2009; 161 (Suppl. 1): 103 (Abstract).
- 148 Ellis R, Kirkham N, Seukeran DC. A case report of malignant melanoma in a user of Melanotan I. Br J Dermatol 2009; 161 (Suppl. 1): 107 (Abstract).
- 149 Madan V, Telfer NR. The paired advancement flap/modified primary closure for nasal tip and supratip defects: 50 cases of the successful use of another Zitelli pearl. Br J Dermatol 2009; 161 (Suppl. 1): 107–8 (Abstract).
- 150 Barry R, Husain A, Lawrence C, Langtry JAA. Paramedian forehead flap: an axial pattern flap based on the supratrochlear artery vascular pedicle or is it random pattern flap? A study of 26 patients. Br J Dermatol 2009; 161 (Suppl. 1): 108 (Abstract).
- 151 Alexandroff AB, Burns J, Khan A et al. Multiple epidermotropic metastatic melanomas: clinicopathological and dermoscopic correlation. Br J Dermatol 2009; 161 (Suppl. 1): 92 (Abstract).
- 152 Mortimer N, Tan E, Salmon P. Nasal sidewall rotation flaps. Br J Dermatol 2009; 161 (Suppl. 1): 108 (Abstract).
- 153 Barry R, Husain A, Dickinson J, Langtry JAA. Microcystic adnexal carcinoma of the forehead with extensive supratrochlear perineural and intraneural infiltration extending into the orbit. Br J Dermatol 2009; 161 (Suppl. 1): 108–9 (Abstract).
- 154 Coates D, Turner RJ. Turner’s knot: the modified subcutaneous buried vertical mattress suture. A new technique for closing high-tension surgical wounds? Br J Dermatol 2009; 161 (Suppl. 1): 104 (Abstract).
- 155 Bryden A, Ogilvie S, Dawe RS, Lewis-Jones S. Randomized controlled trial fails to show superiority of wet wraps over conventional therapy in the treatment of mild to moderate atopic eczema in children under 5 years. Br J Dermatol 2009; 161: (Suppl. 1): 115 (Abstract).
- 156 Akiyama M. FLG mutations in ichthyosis vulgaris and atopic eczema: spectrum of mutations and population genetics. Br J Dermatol 2010; 162: 472–7.
- 157 Ma L, Zhang L, Di ZH et al. Association analysis of filaggrin gene mutations and atopic dermatitis in Northern China. Br J Dermatol 2010; 162: 225–7.
- 158 Kezic S, Kammeyer A, Calkoen F et al. Natural moisturizing factor components in the stratum corneum as biomarkers of filaggrin genotype: evaluation of minimally invasive methods. Br J Dermatol 2009; 161: 1098–104.
- 159 Nemoto-Hasebe I, Akiyama M, Nomura T et al. FLG mutation p.Lys4021X in the C-terminal imperfect filaggrin repeat in Japanese patients with atopic eczema. Br J Dermatol 2009; 161: 1387–90.
- 160 Oji V, Seller N, Sandilands A et al. Ichthyosis vulgaris: novel FLG mutations in the German population and high presence of CD1a+ cells in the epidermis of the atopic subgroup. Br J Dermatol 2009; 160: 771–81.
- 161 Al Enezi T, Sultan A, Chittock J et al. Breakdown of the skin barrier induced by aqueous cream: implications for the management of atopic eczema. Br J Dermatol 2009; 161 (Suppl. 1): 115–16 (Abstract).
- 162 Vourch-Jourdain M, Barbarot S, Taieb A et al. Patient-oriented SCORAD (PO-SCORAD): a self-assessment score in atopic dermatitis: a preliminary feasibility study. Br J Dermatol 2009; 161 (Suppl. 1): 116 (Abstract).
- 163 Sillard L, Labrèze C, Mazereeuw-Hautier J et al. Medial frontofacial capillary malformations: a descriptive study. Br J Dermatol 2009; 161 (Suppl. 1): 117 (Abstract).
- 164 Léauté-Labrèze C, Dumas de la Roque E, Hubiche T et al. Propranolol for severe hemangiomas of infancy. N Engl J Med 2008; 358: 2649–51.
- 165 Sans V, Dumas de la Roque E, Boralevi F et al. Propranolol for severe infantile haemangiomas. Br J Dermatol 2009; 161 (Suppl. 1): 117–18 (Abstract).
- 166 Chiaverini C, Charlesworth A, Bronsard V et al. A genotypic and phenotypic study of 112 cases of junctional epidermolysis bullosa. Br J Dermatol 2009; 161 (Suppl. 1): 118 (Abstract).
- 167 Goujon E, Beer F, Fraitag S, Vabres P. ‘Matchstick’ eyebrow hairs: dermoscopic clues to the diagnosis of Netherton syndrome. Br J Dermatol 2009; 161 (Suppl. 1): 121–2 (Abstract).
- 168 Powell J, Dawber RP, Ferguson DJ et al. Netherton’s syndrome: increased likelihood of diagnosis by examining eyebrow hairs. Br J Dermatol 1999; 141: 544–6.
- 169 Larsen WG. Perfume dermatitis: a study of 20 patients. Arch Dermatol 1977; 113: 623–6.
- 170 Rastogi SC, Menné T, Johansen JD. The composition of fine fragrances is changing. Contact Dermatitis 2003; 48: 130–2.
- 171 Johansen JD, Frosch PJ, Svedman C et al. Hydroxyisohexyl 3-cyclohexene carboxaldehyde – known as Lyral: quantitative aspects and risk assessment of an important fragrance allergen. Contact Dermatitis 2003; 48: 310–16.
- 172 Elberling J, Linneberg A, Mosbech H et al. A link between skin and airways regarding sensitivity to fragrance products? Br J Dermatol 2004; 151: 1197–203.
- 173 Ness AR, Frankel SJ, Gunnell DJ et al. Are we really dying for a tan? BMJ 1999; 319: 114–16.
- 174 Office for National Statistics. 1995 Mortality Statistics. Cause. England and Wales. London: Stationery Office, 1997.
- 175
Elwood JM,
Jopson J.
Melanoma and sun exposure: an overview of published studies.
Int J Cancer
1997; 73: 198–203.
10.1002/(SICI)1097-0215(19971009)73:2<198::AID-IJC6>3.0.CO;2-R CAS PubMed Web of Science® Google Scholar
- 176 Grimes DS, Hindle E, Dyer T. Sunlight, cholesterol and coronary heart disease. QJM 1996; 89: 579–89.
- 177 Alexandroff AB, Pauriah M, Camp RD et al. More than skin deep – atherosclerosis as a systemic manifestation of psoriasis. Br J Dermatol 2009; 161: 1–7.
- 178 Alexandroff AB, Novitskaya ES, Armstrong DJ. Psoriasis as a multisystem inflammatory disease. In: Trends in Dermatology Research ( F Columbus, ed.). Hauppauge, NY: Nova Science, 2010 (in press).
- 179 Wehr TA, Rosenthal NE. Seasonality and affective illness. Am J Psychiatry 1989; 146: 829–39.
- 180 Utiger RD. The need for more vitamin D. N Engl J Med 1998; 338: 828–9.
- 181 Lucas RM, McMichael AJ, Armstrong BK et al. Estimating the global disease burden due to ultraviolet radiation exposure. Int J Epidemiol 2008; 37: 654–67.
- 182 Breuer J, Whitley R. Varicella zoster virus: natural history and current therapies of varicella and herpes zoster. Herpes 2007; 14 (Suppl. 2): 25–9.
- 183 Parker SP, Quinlivan M, Taha Y et al. Genotyping of varicella-zoster virus and the discrimination of Oka vaccine strains by TaqMan real-time PCR. J Clin Microbiol 2006; 44: 3911–14.
- 184 Roozendaal R, Mebius RE, Kraal G. The conduit system of the lymph node. Int Immunol 2008; 20: 1483–7.
- 185 Sigmundsdottir H, Pan J, Debes GF et al. DCs metabolize sunlight-induced vitamin D3 to ‘program’ T cell attraction to the epidermal chemokine CCL27. Nat Immunol 2007; 8: 285–93.
- 186 Zandman-Goddard G, Peeva E, Shoenfeld Y. Gender and autoimmunity. Autoimmun Rev 2007; 6: 366–72.
- 187 Ackerman LS. Sex hormones and the genesis of autoimmunity. Arch Dermatol 2006; 142: 371–6.
- 188 Leduc M, Aractingi S, Khosrotehrani K. Fetal-cell microchimerism, lymphopoiesis, and autoimmunity. Arch Immunol Ther Exp (Warsz) 2009; 57: 325–9.
- 189 Lleo A, Battezzati PM, Selmi C et al. Is autoimmunity a matter of sex? Autoimmun Rev 2008; 7: 626–30.
- 190 Sanchez-Guerrero J, Uribe AG, Jimenez-Santana L et al. A trial of contraceptive methods in women with systemic lupus erythematosus. N Engl J Med 2005; 353: 2539–49.
- 191 Van Vollenhoven RF. Dehydroepiandrosterone for the treatment of systemic lupus erythematosus. Expert Opin Pharmacother 2002; 3: 23–31.
- 192 Rapp SR, Feldman SR, Exum ML et al. Psoriasis causes as much disability as other major medical diseases. J Am Acad Dermatol 1999; 41: 401–7.
- 193 Pickering H. The patient’s journey: living with psoriasis. Br J Gen Pract 2010; 60: 140.
- 194 Seidler EM, Kimball AB. Socioeconomic disability in psoriasis. Br J Dermatol 2009; 161: 1410–12.
- 195 Mak R, Hundhausen C, Botti E et al. The functional role of HLA-Cw6 in psoriasis. Br J Dermatol 2009; 161 (Suppl. 1): 9–10 (Abstract).
- 196 Perera G, Kassen D, Nestle F. A successful therapeutic model for psoriasis: recapitulation of human psoriasis in a xenotransplantation mouse model. Br J Dermatol 2009; 161 (Suppl. 1): 10 (Abstract).
- 197 Thaçi D, Ortonne JP, Goodfield M et al. Treatment of scalp psoriasis with adalimumab: results of the BELIEVE study. Br J Dermatol 2009; 161 (Suppl. 1): 26 (Abstract).
- 198 Perera G, Fonia A, Smith C, Barker JNWN. Etanercept in patients with moderate to severe plaque psoriasis: a retrospective case cohort analysis. Br J Dermatol 2009; 161 (Suppl. 1): 26–7 (Abstract).
- 199 Kulakov E, Kaur M, Velangi SS. A retrospective study of 15 patients treated with infliximab: is weight gain an important consideration? Br J Dermatol 2009; 161 (Suppl. 1): 27 (Abstract).
- 200 Healy E, Schenkel B, Li S et al. Comparison of hospitalization and serious infection rates among patients with moderate to severe psoriasis treated with ustekinumab: comparisons with a large heathcare claims database. Br J Dermatol 2009; 161 (Suppl. 1): 27–8 (Abstract).
- 201 Prinz JC, Stingl G, Yeilding N et al. Ustekinumab has a consistent efficacy and safety profile in patients with moderate to severe psoriasis: results from the PHOENIX 1 and 2 clinical trial programme. Br J Dermatol 2009; 161 (Suppl. 1): 29 (Abstract).
- 202 Papp K, Krueger GG, Rustin MHA et al. Malignancies in ustekinumab-treated psoriasis patients: comparisons with the general U.S. population. Br J Dermatol 2009; 161 (Suppl. 1): 31 (Abstract).
- 203 Ryan C, Kelleher J, Collins P et al. A study to examine if the HLA-Cw*0602 allele is a predictor of response to tumour necrosis factor-α inhibitors in the treatment of psoriasis. Br J Dermatol 2009; 161 (Suppl. 1): 28 (Abstract).
- 204 Bhargava K, Barker JNWN, Smith CE. A retrospective case cohort study of antitumour necrosis factor therapy in severe acral psoriasis. Br J Dermatol 2009; 161 (Suppl. 1): 32–3 (Abstract).
- 205 Kumar N, Armstrong DJ. Cardiovascular disease – the silent killer in rheumatoid arthritis. Clin Med 2008; 8: 384–7.
- 206 Raftery G, Armstrong DJ. ‘Non solum...sed etiam’: added cardiac benefits of TNF alpha blockade in rheumatoid arthritis. J R Coll Physicians Edinb 2008; 38: 108–11.
- 207 Friedewald VE, Cather JC, Gelfand JM et al. AJC editor’s consensus: psoriasis and coronary artery disease. Am J Cardiol 2008; 102: 1631–43.
- 208 Mehta NN, Azfar RS, Shin DB et al. Patients with severe psoriasis are at increased risk of cardiovascular mortality: cohort study using the General Practice Research Database. Eur Heart J 2010; 31: 1000–6.
- 209 Gelfand JM, Troxel AB, Lewis JD et al. The risk of mortality in patients with psoriasis: results from a population-based study. Arch Dermatol 2007; 143: 1493–9.
- 210 Gelfand JM, Neimann AL, Shin DB et al. Risk of myocardial infarction in patients with psoriasis. JAMA 2006; 296: 1735–41.
- 211 Martyn-Simmons CL, Ranawaka RR, Crook MA et al. Assessment of cardiovascular status in patients with moderate to severe psoriasis: a prospective case-controlled cohort study. Br J Dermatol 2009; 161 (Suppl. 1): 6 (Abstract).
- 212 Langan SM, Smeeth L, Hubbard R et al. Bullous pemphigoid and pemphigus vulgaris – incidence and mortality in the UK: population based cohort study. BMJ 2008; 337: a180.
- 213 Langan S, Hubbard R, Fleming K et al. Acute morbidity following a diagnosis of bullous pemphigoid. Br J Dermatol 2009; 161 (Suppl. 1): 1 (Abstract).