Mephedrone, new kid for the chop?

Corresponding Author

Adam R. Winstock

King's College London, Department of Addictions, Institute of Psychiatry, London, UK,

Adam Winstock, King's College London, Department of Addictions, Institute of Psychiatry, De Crespigny Park PO48, London SE5 8AF, UK. E-mail: [email protected]Search for more papers by this author

Luke R. Mitcheson,

Luke R. Mitcheson

South London and Maudsley NHS Trust, London, UK

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Paolo Deluca,

Paolo Deluca

King's College London, Department of Addictions, Institute of Psychiatry, London, UK,

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Zoe Davey,

Zoe Davey

King's College London, Department of Addictions, Institute of Psychiatry, London, UK,

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Ornella Corazza,

Ornella Corazza

University of Hertfordshire, School of Pharmacy, College Lane Campus, Hatfield, UK

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Fabrizio Schifano,

Fabrizio Schifano

University of Hertfordshire, School of Pharmacy, College Lane Campus, Hatfield, UK

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Adam R. Winstock,

Corresponding Author

Adam R. Winstock

King's College London, Department of Addictions, Institute of Psychiatry, London, UK,

Adam Winstock, King's College London, Department of Addictions, Institute of Psychiatry, De Crespigny Park PO48, London SE5 8AF, UK. E-mail: [email protected]Search for more papers by this author

Luke R. Mitcheson,

Luke R. Mitcheson

South London and Maudsley NHS Trust, London, UK

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Paolo Deluca,

Paolo Deluca

King's College London, Department of Addictions, Institute of Psychiatry, London, UK,

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Zoe Davey,

Zoe Davey

King's College London, Department of Addictions, Institute of Psychiatry, London, UK,

Search for more papers by this author

Ornella Corazza,

Ornella Corazza

University of Hertfordshire, School of Pharmacy, College Lane Campus, Hatfield, UK

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Fabrizio Schifano,

Fabrizio Schifano

University of Hertfordshire, School of Pharmacy, College Lane Campus, Hatfield, UK

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First published: 23 August 2010

https://doi.org/10.1111/j.1360-0443.2010.03130.x

Citations: 254

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ABSTRACT

Aims Mephedrone (4-methylmethcathinone) is a novel synthetic stimulant drug that has recently become popular in the United Kingdom and elsewhere in Europe. It has a short history of human consumption and little is known about its prevalence and pattern of use. This study aimed to obtain preliminary data on its use and effects among dance drug users in the United Kingdom.

Design Cross-sectional anonymous online survey of mephedrone recruited as part of larger study exploring patterns of drug use among those associated with the dance music scene.

Setting UK-based dance music and clubbing website.

Participants A total of 947 ever users of mephedrone recruited as part of a wider study on dance drug use patterns.

Measurements Assessment of demographics, ever and current drug use and patterns and selected effects following use of mephedrone.

Findings A total of 947 (41.3%) of 2295 participants reported ever having used mephedrone. Mephedrone was the sixth most frequently used drug in the last month after tobacco, alcohol, cannabis, cocaine and 3,4-methylenedioxymethamphetamine (MDMA). Users were typically younger (P < 0.001) and male (P < 0.01); 15.1% reported using weekly or more frequently; 49.5% reported using between 0.5 and 1 g during a typical session; 69.5% reported that intranasal use was the most common route of use. Intranasal use was associated with increased abuse liability; 54.6% of those who have also used cocaine reported that the quality of the high obtained with mephedrone was better, with those using intranasally being significantly more likely than those who took the drug orally to report that mephedrone was more addictive (P < 0.02) and more risky (P < 0.02) than cocaine. Route of use was unrelated to any stimulant-related adverse effect apart from palpitations (P < 0.005).

Conclusions Mephedrone appears to be used primarily intranasally and to have comparable abuse potential to cocaine, with more than half those who use both reporting that mephedrone gives a better quality high.

References

1 Psychonaut Web Mapping Research Group. Mephedrone Report. London, UK: Institute of Psychiatry, King's College London; 2009.
Web of Science® Google Scholar
2 Winstock A. R., Ramsey J. Legal highs and the challenges for policy makers. Addiction. Epub ahead of print 19 March 2010.
PubMed Web of Science® Google Scholar
3 Newcombe R. Mephedrone: Use of Mephedrone (M-Cat, Meow) in Middlesbrough. Manchester, UK: Lifeline Publications; 2009.
Google Scholar
4 Google Insights for Search: Mephedrone [internet]. Google Insights for Search; 2009. Available at: http://www.google.com/insights/search/#q=mephedrone&cmpt=q (accessed 8 February 2009). (Archived at http://www.webcitation.org/5ri0QjQCN)
Google Scholar
5 Levy A. Teenager dies; after experimenting with legal drug meow meow. Mail Online ; 2010. Available at: http://www.dailymail.co.uk/news/article-1245078/Teenager-dies-experimenting-legal-drug-meow-meow.html (Archived at http://www.webcitation.org/5ri0ZihHb)
Google Scholar
6 McGuiness R. Girl, 14, killed by legal web drug meow meow. The Metro ; 2009. Available at: http://www.e-edition.metro.co.uk/2009/11/25 (Archived at http://www.webcitation.org/5ri0Tow6i)
Google Scholar
7 Williams M. Doctors call for ban on ‘legal high’ after woman dies. Herald Scotland ; 2010. Available at: http://www.heraldscotland.com/news/health/doctors-call-for-ban-on-legal-high-after-woman-dies-1.1002660 (Archived at http://www.webcitation.org/5ri0eIVGY)
Google Scholar
8 Campbell D. Online sales of legal alternatives to class A drug raise safety fears. Guardian ; 2009. Available at: http://www.guardian.co.uk/society/2009/mar/12/online-legal-drugs-stimulants (Archived at http://www.webcitation.org/5ri0i9Kc1)
Google Scholar
9 The Local. Teenager dies of ‘net drug’ overdose. The Local: Sweden's News in English ; 2008. Available at: http://www.thelocal.se/16366/20081215 (Archived at http://www.webcitation.org/5ri0oT3NY)
Google Scholar
10 Gustavaaon D., Escher C. Mephedrone: internet drug which seems to have come and stay. Fatal cases in Sweden have drawn attention to previously unknown substance [in Swedish]. Lakartidningen 2009; 106: 2769–71.
PubMed Google Scholar
11 Europol–European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). Joint Report on A New Psychoactive Substance: 4-Methylmethcathinone (Mephedrone). Portugal: Lisbon; 2010.
Web of Science® Google Scholar
12 Meyer M. R., Wilhelm J., Peters F. T., Maurer H. H. Beta-keto amphetamines: studies on the metabolism of the designer drug mephedrone and toxicological detection of mephedrone, butylone, and methylone in urine using gas chromatography-mass spectrometry. Anal Bioanal Chem 2010; 397: 1225–33. Epub 2010 25 March.
10.1007/s00216-010-3636-5
CAS PubMed Web of Science® Google Scholar
13 Davies S., Button J., Archer R., Ramsey J., Holt D. W. Methcathinone derivatives: findings from test purchases of capsules and powders from the Internet [Abstract]. Special Edition: The International Association of Forensic Toxicologists—TIAFT—47th International Meeting. Ann Toxicol Anal 2009; 21: 61.
Web of Science® Google Scholar
14 Davies S., Puchnarewicz M., Button J., Dargan P. I., Wood D. M., Archer R. et al. Two cases of confirmed ingestions of the novel designer compounds: 4-methylmethcathinone (mephedrone) and 3-fluoromethcathinone [Abstract]. Special Edition: The International Association of Forensic Toxicologists—TIAFT—47th International Meeting. Ann Toxicol Anal 2009; 21: 60–1.
Google Scholar
15 Wood D. M., Greene S. L., Dargan P. I. Clinical pattern of toxicity associated with the novel synthetic cathinone mephedrone. Emerg Med J 2010. Epub ahead of print. DOI: 10.1136/3mj.2010.092288
10.1136/emj.2010.092288
PubMed Web of Science® Google Scholar
16 Winstock A. R., Griffiths P., Stewart D. Drugs and the dance music scene: a survey of current drug use patterns among a sample of dance music enthusiasts in the UK. Drug Alcohol Depend 2001; 64: 9–17.
10.1016/S0376-8716(00)00215-5
CAS PubMed Web of Science® Google Scholar
17 Winstock A. R., Wolff K., Ramsey J. 4 MTA a new synthetic drug on the dance scene. Drug Alcohol Depend 2002; 67: 111–15.
10.1016/S0376-8716(02)00018-2
CAS PubMed Web of Science® Google Scholar
18 Mitcheson L., McCambridge J., Bryne A., Hunt N., Winstock A. R. Sexual health risk among dance drug users: cross-sectional comparisons with nationally representative data. Int J Drug Policy 2008; 19: 304–10.
10.1016/j.drugpo.2007.02.002
PubMed Web of Science® Google Scholar
19 McCambridge J., Mitcheson L., Winstock A. R., Hunt N. Five-year trends in patterns of drug use among people who use stimulants in dance contexts in the United Kingdom. Addiction 2005; 100: 1140–49.
10.1111/j.1360-0443.2005.001127.x
CAS PubMed Web of Science® Google Scholar
20 McCambridge J., Winstock A. R., Mitcheson L., Hunt N. Five-year trends in patterns of hallucinogen use among people in dance contexts in the United Kingdom. Eur Addict Res 2007; 13: 57–64.
10.1159/000095816
PubMed Web of Science® Google Scholar
21 Farre M., Cami J. Pharmokinetic considerations in abuse liability evaluation. Addiction 2006; 86: 1601–6.
10.1111/j.1360-0443.1991.tb01754.x
Google Scholar
22 Kalix P. Cathinone, a natural amphetamine. Pharmacol Toxicol 1992; 70: 77–86.
10.1111/j.1600-0773.1992.tb00434.x
CAS PubMed Web of Science® Google Scholar
23 Williamson S., Gossop M., Powis B., Griffiths P., Fountain J., Strang J. Adverse effects of stimulant drugs in a community sample of drug users. Drug Alcohol Depend 1997; 44: 87–94.
10.1016/S0376-8716(96)01324-5
CAS PubMed Web of Science® Google Scholar
24 Al-Motarreb A., Al-Kebsi M., Al-Adhi B., Broadley K. J. Khat chewing and acute myocardial infarction. Heart 2002; 87: 279–80.
10.1136/heart.87.3.279
CAS PubMed Web of Science® Google Scholar
25 Broadly K. J. The vascular effects of trace amines and amphetamines. Pharmacol Ther 2010; 125: 363–75.
10.1016/j.pharmthera.2009.11.005
CAS PubMed Web of Science® Google Scholar
26 De Bie R. M., Gladstone R. M., Strafella A. P., Ko J. H., Manganese-induced L. A. E. Parkinsonism associated with methcathinone (Ephedrone) abuse. Arch Neurol 2007; 64: 886–9.
10.1001/archneur.64.6.886
PubMed Web of Science® Google Scholar
27 Stepens A., Logina I., Liguts V., Aldins P., Eksteina I., Platkājis A. et al. Parkinsonian syndrome in methcathinone users and the role of manganese. N Engl J Med 2008; 358: 1009–17.
10.1056/NEJMoa072488
CAS PubMed Web of Science® Google Scholar
28 Schifano F., Corkery J. Cocaine/crack cocaine consumption, treatment demand, seizures, related offences, prices, average purity levels and deaths in the UK (1990 2004). J Psychopharmacol 2008; 22: 71–9.
10.1177/0269881107079170
PubMed Web of Science® Google Scholar
29 Hand T., Rishiraj A. S. Seizures of Drugs in England and Wales, 2008/09. 2009; London: Home Office Statistical Bulletin; 2009.
Google Scholar
30 Brandt S. D., Sumnall H. R., Measham F., Cole J. The confusing case of NRG-1, second generation mephedrone. BMJ 2010; 341: c3564.
10.1136/bmj.c3564
PubMed Web of Science® Google Scholar
31 Measham F., Moore K., Newcombe R., Welch Z. Tweaking, bombing, dabbing, and stockpiling: the emergence of mephedrone and the perversity of prohibition. Drugs Alcohol Today 2010; 10: 14–21.
10.5042/daat.2010.0123
Google Scholar
32 Schifano F., Deluca P., Agosti L., Martinotti G., Corkery J. The Psychonaut Research Group. New trends in the cyber and street market of recreational drugs? The case of 2C-T-7 (‘Blue Mystic’). J Psychopharmacol 2005; 19: 675–9.
10.1177/0269881105056660
CAS PubMed Web of Science® Google Scholar
33 Schifano F., Deluca P., Baldacchino A., Peltoniemi T., Scherbaum N., Torrens M. et al. Drugs on the web; the Psychonaut 2002 EU project. Prog Neuropsychopharmacol Biol Psychiatry 2006; 30: 640–6.
10.1016/j.pnpbp.2005.11.035
PubMed Web of Science® Google Scholar
34 Winstock A. R., Marsden J., Mitcheson L. What should be done about mephedrone. BMJ 2010; 340: c1605.
10.1136/bmj.c1605
PubMed Web of Science® Google Scholar

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January 2011

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