Dopamine release in ventral striatum during Iowa Gambling Task performance is associated with increased excitement levels in pathological gambling
Corresponding Author
Jakob Linnet
Center of Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark
Pathophysiology and Experimental Tomography Center, Aarhus University Hospital, Aarhus, Denmark
Jakob Linnet, PET/CFIN, Aarhus University Hospital, Aarhus Sygehus, Nørrebrogade 44, Building 10G, DK-8000 Aarhus C, Denmark. E-mail: [email protected]Search for more papers by this authorArne Møller
Center of Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark
Pathophysiology and Experimental Tomography Center, Aarhus University Hospital, Aarhus, Denmark
Search for more papers by this authorEricka Peterson
Center of Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark
Pathophysiology and Experimental Tomography Center, Aarhus University Hospital, Aarhus, Denmark
Search for more papers by this authorAlbert Gjedde
Center of Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark
Pathophysiology and Experimental Tomography Center, Aarhus University Hospital, Aarhus, Denmark
Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark
Search for more papers by this authorDoris Doudet
Center of Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark
Pathophysiology and Experimental Tomography Center, Aarhus University Hospital, Aarhus, Denmark
Department of Neurology, University of British Columbia, Vancouver, Canada
Search for more papers by this authorCorresponding Author
Jakob Linnet
Center of Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark
Pathophysiology and Experimental Tomography Center, Aarhus University Hospital, Aarhus, Denmark
Jakob Linnet, PET/CFIN, Aarhus University Hospital, Aarhus Sygehus, Nørrebrogade 44, Building 10G, DK-8000 Aarhus C, Denmark. E-mail: [email protected]Search for more papers by this authorArne Møller
Center of Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark
Pathophysiology and Experimental Tomography Center, Aarhus University Hospital, Aarhus, Denmark
Search for more papers by this authorEricka Peterson
Center of Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark
Pathophysiology and Experimental Tomography Center, Aarhus University Hospital, Aarhus, Denmark
Search for more papers by this authorAlbert Gjedde
Center of Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark
Pathophysiology and Experimental Tomography Center, Aarhus University Hospital, Aarhus, Denmark
Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark
Search for more papers by this authorDoris Doudet
Center of Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark
Pathophysiology and Experimental Tomography Center, Aarhus University Hospital, Aarhus, Denmark
Department of Neurology, University of British Columbia, Vancouver, Canada
Search for more papers by this authorABSTRACT
Aims Gambling excitement is believed to be associated with biological measures of pathological gambling. Here, we tested the hypothesis that dopamine release would be associated with increased excitement levels in Pathological Gamblers compared with Healthy Controls.
Design Pathological Gamblers and Healthy Controls were experimentally compared in a non-gambling (baseline) and gambling condition.
Measurements We used Positron Emission Tomography (PET) with the tracer raclopride to measure dopamine D 2/3 receptor availability in the ventral striatum during a non-gambling and gambling condition of the Iowa Gambling Task (IGT). After each condition participants rated their excitement level.
Setting Laboratory experiment.
Participants 18 Pathological Gamblers and 16 Healthy Controls.
Findings Pathological Gamblers with dopamine release in the ventral striatum had significantly higher excitement levels than Healthy Controls despite lower IGT performance. No differences in excitement levels and IGT performance were found between Pathological Gamblers and Healthy Controls without dopamine release. Pathological Gamblers showed a significant correlation between dopamine release and excitement level, while no such interaction was found in Healthy Controls.
Conclusions In pathological gamblers dopamine release in the ventral striatum appears to be associated with increased excitement levels despite lower IGT performance. The results might suggest a ‘double deficit’ function of dopamine in pathological gambling, where dopamine release reinforces maladaptive gambling through increasing excitement levels, reducing inhibition of risky decisions, or a combination of both. These findings may have implications for the understanding of dopamine in pathological gambling and other forms of addiction.
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