INVITED REVIEW
Stress/cell death pathways, neuroinflammation, and neuropathic pain
Lu Li,
Tian Li,
Xinyu Qu,
Guangwei Sun,
Qi Fu,
Guang Han,
Lu Li
Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China
Search for more papers by this authorCorresponding Author
Tian Li
School of Basic Medicine, Fourth Military Medical University, Xi'an, Shaanxi, China
Correspondence
Guang Han and Tian Li, Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang 110003, Liaoning, China.
Email: [email protected] and [email protected]; [email protected]
Search for more papers by this authorXinyu Qu
Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China
Search for more papers by this authorGuangwei Sun
Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China
Search for more papers by this authorQi Fu
Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China
Search for more papers by this authorCorresponding Author
Guang Han
Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China
Correspondence
Guang Han and Tian Li, Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang 110003, Liaoning, China.
Email: [email protected] and [email protected]; [email protected]
Search for more papers by this authorLu Li,
Tian Li,
Xinyu Qu,
Guangwei Sun,
Qi Fu,
Guang Han,
Lu Li
Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China
Search for more papers by this authorCorresponding Author
Tian Li
School of Basic Medicine, Fourth Military Medical University, Xi'an, Shaanxi, China
Correspondence
Guang Han and Tian Li, Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang 110003, Liaoning, China.
Email: [email protected] and [email protected]; [email protected]
Search for more papers by this authorXinyu Qu
Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China
Search for more papers by this authorGuangwei Sun
Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China
Search for more papers by this authorQi Fu
Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China
Search for more papers by this authorCorresponding Author
Guang Han
Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China
Correspondence
Guang Han and Tian Li, Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang 110003, Liaoning, China.
Email: [email protected] and [email protected]; [email protected]
Search for more papers by this authorThis article is part of a series of reviews covering Mechanisms of programmed cell death appearing in Volume 321 of Immunological Reviews.
Summary
Neuropathic pain is a common and debilitating modality of chronic pain induced by a lesion or disease of the somatosensory nervous system. Albeit the elucidation of numerous pathophysiological mechanisms and the development of potential treatment compounds, safe and reliable therapies of neuropathic pain remain poor. Multiple stress/cell death pathways have been shown to be implicated in neuroinflammation during neuropathic pain. Here, we summarize the current knowledge of stress/cell death pathways and present an overview of the roles and molecular mechanisms of stress/cell death pathways in neuroinflammation during neuropathic pain, covering intrinsic and extrinsic apoptosis, autophagy, mitophagy, ferroptosis, pyroptosis, necroptosis, and phagoptosis. Small molecule compounds that modulate stress/cell death pathways in alleviating neuropathic pain are discussed mainly based on preclinical neuropathic pain models. These findings will contribute to in-depth understanding of the pathological processes during neuropathic pain as well as bridge the gap between basic and translational research to uncover new neuroprotective interventions.
CONFLICT OF INTEREST STATEMENT
The authors declare that there are no conflicts of interest.
Open Research
DATA AVAILABILITY STATEMENT
The datasets analyzed during the current study are available from the corresponding author on reasonable request.
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