Differences in lipid profiles in two Hispanic ischemic stroke populations
Corresponding Author
A. Arauz
Stroke Clinic, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico
Correspondence: Antonio Arauz, Stroke Clinic, National Institute of Neurology and Neurosurgery Manuel Velasco Suárez, Insurgentes Sur 3877, Colonia La Fama, México City (DF), CP 14269, México.
E-mail: [email protected], [email protected]
Search for more papers by this authorJ. G. Romano
Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA
Search for more papers by this authorA. Ruiz-Franco
Stroke Clinic, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico
Search for more papers by this authorT. Shang
Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA
Search for more papers by this authorC. Dong
Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA
Search for more papers by this authorT. Rundek
Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA
Search for more papers by this authorS. Koch
Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA
Search for more papers by this authorB. Hernández-Curiel
Stroke Clinic, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico
Search for more papers by this authorJ. Pacheco
Stroke Clinic, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico
Search for more papers by this authorP. Rojas
Stroke Clinic, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico
Search for more papers by this authorF. Ruiz-Navarro
Stroke Clinic, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico
Search for more papers by this authorM. Katsnelson
Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA
Search for more papers by this authorR. L. Sacco
Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA
Search for more papers by this authorCorresponding Author
A. Arauz
Stroke Clinic, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico
Correspondence: Antonio Arauz, Stroke Clinic, National Institute of Neurology and Neurosurgery Manuel Velasco Suárez, Insurgentes Sur 3877, Colonia La Fama, México City (DF), CP 14269, México.
E-mail: [email protected], [email protected]
Search for more papers by this authorJ. G. Romano
Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA
Search for more papers by this authorA. Ruiz-Franco
Stroke Clinic, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico
Search for more papers by this authorT. Shang
Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA
Search for more papers by this authorC. Dong
Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA
Search for more papers by this authorT. Rundek
Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA
Search for more papers by this authorS. Koch
Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA
Search for more papers by this authorB. Hernández-Curiel
Stroke Clinic, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico
Search for more papers by this authorJ. Pacheco
Stroke Clinic, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico
Search for more papers by this authorP. Rojas
Stroke Clinic, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico
Search for more papers by this authorF. Ruiz-Navarro
Stroke Clinic, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico
Search for more papers by this authorM. Katsnelson
Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA
Search for more papers by this authorR. L. Sacco
Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA
Search for more papers by this authorAbstract
Background and Purpose
The study aims to compare lipid profiles among ischemic stroke patients in a predominantly Caribbean-Hispanic population in Miami and a Mestizo Hispanic population in Mexico City.
Methods
We analyzed ischemic stroke Hispanic patients with complete baseline fasting lipid profile enrolled contemporaneously in the prospective registries of two tertiary care teaching hospitals in Mexico City and Miami. Demographic characteristics, risk factors, medications, ischemic stroke subtype, and first fasting lipid profile were compared. Vascular risk factor definitions were standardized. Multiple linear regression analysis was performed to compare lipid fractions.
Results
A total of 324 patients from Mexico and 236 from Miami were analyzed. Mexicans were significantly younger (58·1 vs. 67·4 years), had a lower frequency of hypertension (53·4% vs. 79·7%), and lower body mass index (27 vs. 28·5). There was a trend toward greater prevalence of diabetes in Mexicans (31·5 vs. 24·6%, P = 0·07). Statin use at the time of ischemic stroke was more common in Miami Hispanics (18·6 vs. 9·4%). Mexicans had lower total cholesterol levels (169·9 ± 46·1 vs. 179·9 ± 48·4 mg/dl), lower low-density lipoprotein (92·3 ± 37·1 vs. 108·2 ± 40·8 mg/dl), and higher triglyceride levels (166·9 ± 123·9 vs. 149·2 ± 115·2 mg/dl). These differences remained significant after adjusting for age, gender, hypertension, diabetes, body mass index, smoking, ischemic stroke subtype, and statin use.
Conclusion
We found significant differences in lipid fractions in Hispanic ischemic stroke patients, with lower total cholesterol and low-density lipoprotein, and higher triglyceride levels in Mexicans. These findings highlight the heterogeneity of dyslipidemia among the Hispanic race-ethnic group and may lead to different secondary prevention strategies.
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