Neonatal haemostatic parameters in correlation to gestational age and birth weight
Corresponding Author
Georgios Mitsiakos
Second Neonatal Department and Neonatal Intensive Care Unit (NICU), Aristotle University of Thessaloniki, “Papageorgiou” Hospital, Thessaloniki, Greece
Correspondence
Georgios Mitsiakos, Second Neonatal Department and Neonatal Intensive Care Unit, Aristotle University of Thessaloniki, “Papageorgiou” Hospital, Ring Road, Nea Efkarpia, Thessaloniki, PC 56403, Greece.
Email: [email protected]
Search for more papers by this authorGeorgios N. Katsaras
Second Neonatal Department and Neonatal Intensive Care Unit (NICU), Aristotle University of Thessaloniki, “Papageorgiou” Hospital, Thessaloniki, Greece
Search for more papers by this authorAbraham Pouliakis
Second Department of Pathology, National and Kapodistrian University of Athens, "ATTIKON" University Hospital, Athens, Greece
Search for more papers by this authorEmmanouil Papadakis
Hematology Department – Hemostasis Unit, “Papageorgiou” Hospital, Thessaloniki, Greece
Search for more papers by this authorIlias Chatziioannidis
Second Neonatal Department and Neonatal Intensive Care Unit (NICU), Aristotle University of Thessaloniki, “Papageorgiou” Hospital, Thessaloniki, Greece
Search for more papers by this authorChristina Mitsiakou
Second Neonatal Department and Neonatal Intensive Care Unit (NICU), Aristotle University of Thessaloniki, “Papageorgiou” Hospital, Thessaloniki, Greece
Search for more papers by this authorDimitra Gialamprinou
Second Neonatal Department and Neonatal Intensive Care Unit (NICU), Aristotle University of Thessaloniki, “Papageorgiou” Hospital, Thessaloniki, Greece
Search for more papers by this authorEfthimia Papacharalampous
Second Neonatal Department and Neonatal Intensive Care Unit (NICU), Aristotle University of Thessaloniki, “Papageorgiou” Hospital, Thessaloniki, Greece
Search for more papers by this authorAnna Kioumi
Hematology Department – Hemostasis Unit, “Papageorgiou” Hospital, Thessaloniki, Greece
Search for more papers by this authorMiranda Athanasiou
First Paediatric Department, Aristotle University of Thessaloniki, Thessaloniki, Greece
Search for more papers by this authorFani Athanassiadou
Second Paediatric Department, Aristotle University of Thessaloniki, Thessaloniki, Greece
Search for more papers by this authorDimitrios Sfoungaris
First Department of Pediatric Surgery, Faculty of Medicine, Aristotle University of Thessaloniki, “G. Genimatas” Hospital, Thessaloniki, Greece
Search for more papers by this authorNikolaos Nikolaidis
Second Neonatal Department and Neonatal Intensive Care Unit (NICU), Aristotle University of Thessaloniki, “Papageorgiou” Hospital, Thessaloniki, Greece
Search for more papers by this authorCorresponding Author
Georgios Mitsiakos
Second Neonatal Department and Neonatal Intensive Care Unit (NICU), Aristotle University of Thessaloniki, “Papageorgiou” Hospital, Thessaloniki, Greece
Correspondence
Georgios Mitsiakos, Second Neonatal Department and Neonatal Intensive Care Unit, Aristotle University of Thessaloniki, “Papageorgiou” Hospital, Ring Road, Nea Efkarpia, Thessaloniki, PC 56403, Greece.
Email: [email protected]
Search for more papers by this authorGeorgios N. Katsaras
Second Neonatal Department and Neonatal Intensive Care Unit (NICU), Aristotle University of Thessaloniki, “Papageorgiou” Hospital, Thessaloniki, Greece
Search for more papers by this authorAbraham Pouliakis
Second Department of Pathology, National and Kapodistrian University of Athens, "ATTIKON" University Hospital, Athens, Greece
Search for more papers by this authorEmmanouil Papadakis
Hematology Department – Hemostasis Unit, “Papageorgiou” Hospital, Thessaloniki, Greece
Search for more papers by this authorIlias Chatziioannidis
Second Neonatal Department and Neonatal Intensive Care Unit (NICU), Aristotle University of Thessaloniki, “Papageorgiou” Hospital, Thessaloniki, Greece
Search for more papers by this authorChristina Mitsiakou
Second Neonatal Department and Neonatal Intensive Care Unit (NICU), Aristotle University of Thessaloniki, “Papageorgiou” Hospital, Thessaloniki, Greece
Search for more papers by this authorDimitra Gialamprinou
Second Neonatal Department and Neonatal Intensive Care Unit (NICU), Aristotle University of Thessaloniki, “Papageorgiou” Hospital, Thessaloniki, Greece
Search for more papers by this authorEfthimia Papacharalampous
Second Neonatal Department and Neonatal Intensive Care Unit (NICU), Aristotle University of Thessaloniki, “Papageorgiou” Hospital, Thessaloniki, Greece
Search for more papers by this authorAnna Kioumi
Hematology Department – Hemostasis Unit, “Papageorgiou” Hospital, Thessaloniki, Greece
Search for more papers by this authorMiranda Athanasiou
First Paediatric Department, Aristotle University of Thessaloniki, Thessaloniki, Greece
Search for more papers by this authorFani Athanassiadou
Second Paediatric Department, Aristotle University of Thessaloniki, Thessaloniki, Greece
Search for more papers by this authorDimitrios Sfoungaris
First Department of Pediatric Surgery, Faculty of Medicine, Aristotle University of Thessaloniki, “G. Genimatas” Hospital, Thessaloniki, Greece
Search for more papers by this authorNikolaos Nikolaidis
Second Neonatal Department and Neonatal Intensive Care Unit (NICU), Aristotle University of Thessaloniki, “Papageorgiou” Hospital, Thessaloniki, Greece
Search for more papers by this authorAbstract
Introduction
The aim of our study was to establish reference ranges for neonatal coagulation and fibrinolysis parameters and to investigate their relationship with gestational age (GA) and birth weight (BW).
Methods
A single-centre prospective study was conducted in all healthy neonates born in our hospital during the study period, excluding those with maternal or neonatal disorders and diseases that affect haemostasis. The following parameters were measured: fibrinogen, prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (aPTT) as well as factors II, V, VII, VIII, IX, X, XI and XII, von Willebrand (vWF), protein C, free protein S, antithrombin (AT), activated protein C resistance (APCr), tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1).
Results
Study population consisted of 327 neonates. Fibrinogen, AT III, proteins C and S, PAI-1, vWF and factors II, V, VIII, IX, XI and XII were positively correlated, while PT, aPPT, INR, APCr and tPA were negatively correlated with GA and BW. Proteins C and S, factors II, VIII, IX, XI and vWF, as well AT III and PAI-1 had a significant positive linear correlation with GA, while aPTT had a significant negative one. Fibrinogen, and factors V, VII and XII had a significant positive linear correlation with BW, while factor VIII, tPA, as well PT and INR had a significant negative one.
Conclusion
Fibrinogen, AT III, proteins C and S, PAI-1, vWF and factors II, V, VIII, IX, XI and XII increase with GA and BW.
CONFLICT OF INTEREST
The authors declare no conflict of interest.
Open Research
DATA AVAILABILITY STATEMENT
All data generated or analyzed during this study are included in this article. Further enquiries can be directed to the corresponding author.
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