Leukemic presentation with discordant morphology in triple-hit lymphoma—A diagnostic pitfall during COVID-19 pandemic
Debadrita Ray
Department of Hematology, Postgraduate Institute of Medical Education & Research, Chandigarh, India
Search for more papers by this authorCorresponding Author
Nabhajit Mallik
Department of Hematology, Postgraduate Institute of Medical Education & Research, Chandigarh, India
Correspondence
Nabhajit Mallik, Department of Hematology, Research Block-A, Postgraduate Institute of Medical Education & Research, Sector-12, Chandigarh, India.
Email: [email protected]
Search for more papers by this authorSreejesh Sreedharanunni
Department of Hematology, Postgraduate Institute of Medical Education & Research, Chandigarh, India
Search for more papers by this authorArihant Jain
Department of Internal Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh, India
Search for more papers by this authorAmanjit Bal
Department of Histopathology, Postgraduate Institute of Medical Education & Research, Chandigarh, India
Search for more papers by this authorMan Updesh Singh Sachdeva
Department of Hematology, Postgraduate Institute of Medical Education & Research, Chandigarh, India
Search for more papers by this authorDebadrita Ray
Department of Hematology, Postgraduate Institute of Medical Education & Research, Chandigarh, India
Search for more papers by this authorCorresponding Author
Nabhajit Mallik
Department of Hematology, Postgraduate Institute of Medical Education & Research, Chandigarh, India
Correspondence
Nabhajit Mallik, Department of Hematology, Research Block-A, Postgraduate Institute of Medical Education & Research, Sector-12, Chandigarh, India.
Email: [email protected]
Search for more papers by this authorSreejesh Sreedharanunni
Department of Hematology, Postgraduate Institute of Medical Education & Research, Chandigarh, India
Search for more papers by this authorArihant Jain
Department of Internal Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh, India
Search for more papers by this authorAmanjit Bal
Department of Histopathology, Postgraduate Institute of Medical Education & Research, Chandigarh, India
Search for more papers by this authorMan Updesh Singh Sachdeva
Department of Hematology, Postgraduate Institute of Medical Education & Research, Chandigarh, India
Search for more papers by this authorCONFLICT OF INTEREST
The authors report no conflict of interest.
Open Research
DATA AVAILABILITY STATEMENT
Data sharing is not applicable to this article as no new data were created or analyzed in this study.
REFERENCES
- 1Scott DW, King RL, Staiger AM, et al. High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements with diffuse large B-cell lymphoma morphology. Blood. 2018; 131(18): 2060-2064.
- 2Petrich AM, Gandhi M, Jovanovic B, et al. Impact of induction regimen and stem cell transplantation on outcomes in double-hit lymphoma: a multicenter retrospective analysis. Blood. 2014; 124(15): 2354-2361.
- 3Howlett C, Snedecor SJ, Landsburg DJ, et al. Front-line, dose-escalated immunochemotherapy is associated with a significant progression-free survival advantage in patients with double-hit lymphomas: a systematic review and meta-analysis. Br J Haematol. 2015; 170(4): 504-514.
- 4Shahid M, Seifert R, Li P, et al. Leukemic presentation of high-grade B cell lymphoma with MYC and BCL2 rearrangement—a series of two cases and review of literature. J Hematop. 2019; 12(1): 41-45.
- 5Ziemba J, Wolf Z, Weinstock M, et al. Double-hit and triple-hit follicular lymphoma: case series and review of 40 cases. Am J Clin Pathol. 2020; 153(5): 672-685.
- 6Kremer M, Spitzer M, Mandl-Weber S, et al. Discordant bone marrow involvement in diffuse large B-cell lymphoma: comparative molecular analysis reveals a heterogeneous group of disorders. Lab Invest. 2003; 83: 107-114.
- 7Robertson LE, Redman JR, Butler JJ, et al. Discordant bone marrow involvement in diffuse large-cell lymphoma: a distinct clinical-pathologic entity associated with a continuous risk of relapse. J Clin Oncol. 1991; 9(2): 236-242.
- 8Hodges GF, Lenhardt TM, Cotelingam JD. Bone marrow involvement in large-cell lymphoma: prognostic implications of discordant disease. Am J Clin Pathol. 1994; 101(3): 305-311.
- 9Nakano M, Kawanishi Y, Kuge S, et al. Clinical and prognostic significance of monoclonal small cells in the peripheral blood and bone marrow of various B-cell lymphomas. Blood. 1992; 79(12): 3253-3260.
- 10Crisan D, Mattson JC. Discordant morphologic features in bone marrow involvement by malignant lymphomas: Use of gene rearrangement patterns for diagnosis. Am J Hematol. 1995; 49(4): 299-309.