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An inherited variant of transcription factor RUNX1 related to thrombocytopenia with predisposition to acute myeloid leukaemia
Ye Tian,
Ye Tian
Department of Hematology, The First Affiliated Hospital of Dalian Medical University, Dalian, China
Search for more papers by this author Si-Xun Jia,
Si-Xun Jia
Department of Hematology, Affiliated Zhongshan Hospital of Dalian University, Dalian, China
Search for more papers by this author Jie Shi,
Jie Shi
Department of Hematology, Affiliated Zhongshan Hospital of Dalian University, Dalian, China
Search for more papers by this author Mei-Yun Fang,
Corresponding Author
Mei-Yun Fang
Department of Hematology, Affiliated Zhongshan Hospital of Dalian University, Dalian, China
Correspondence
Mei-Yun Fang, Department of Hematology, Affiliated Zhongshan Hospital of Dalian University, No. 6 Jiefang Street, ZhongShan District, Dalian 116001, China.
Email: [email protected]
Search for more papers by this author
Ye Tian,
Ye Tian
Department of Hematology, The First Affiliated Hospital of Dalian Medical University, Dalian, China
Search for more papers by this author Si-Xun Jia,
Si-Xun Jia
Department of Hematology, Affiliated Zhongshan Hospital of Dalian University, Dalian, China
Search for more papers by this author Jie Shi,
Jie Shi
Department of Hematology, Affiliated Zhongshan Hospital of Dalian University, Dalian, China
Search for more papers by this author Mei-Yun Fang,
Corresponding Author
Mei-Yun Fang
Department of Hematology, Affiliated Zhongshan Hospital of Dalian University, Dalian, China
Correspondence
Mei-Yun Fang, Department of Hematology, Affiliated Zhongshan Hospital of Dalian University, No. 6 Jiefang Street, ZhongShan District, Dalian 116001, China.
Email: [email protected]
Search for more papers by this author
First published: 29 April 2019
No abstract is available for this article.
REFERENCES
- 1Churpek JE, Pyrtel K, Kanchi K-L, et al. Genomic analysis of germ line and somatic variants in familial myelodysplasia/acute myeloid leukemia. Blood. 2015; 126: 2484-2490.
- 2Owen CJ, Toze CL, Koochin A, et al. Five new pedigrees with inherited RUNX1 mutations causing familial platelet disorder with propensity to myeloid malignancy. Blood. 2008; 112: 4639-4645.
- 3Koeffler HP, Leong G. Preleukemia: one name, many meanings. Leukemia. 2017; 31: 534-542.
- 4Shlush LI, Zandi S, Mitchell A, et al. Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia. Nature. 2014; 506: 328-333.
- 5Corces-Zimmerman MR, Hong W-J, Weissman IL, Medeiros BC, Majeti R. Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission. Proc Natl Acad Sci USA. 2014; 111: 2548-2553.
- 6Klco JM, Miller CA, Griffith M, et al. Association between mutation clearance after induction therapy and outcomes in acute myeloid leukemia. J Am Med Assoc. 2015; 314: 811-822.
